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During the last 15 years the research on homocysteine and the vitamins involved in its metabolism has become very dynamic. About 1,500 publications on the subject are now published each year. The research has long mainly focused on the association between homocysteine and cardiovascular disease, but also pregnancy complications/ fetal malformations. There is, however, an increasing interest in the connection between the homocysteine metabolism and neuropsychiatric disease with a steeply increasing number of publications. In particular, the association between homocysteine metabolism and cognit

Homocysteine --- Neurobehavioral disorders. --- Mental illness --- Vitamin therapy. --- Pathophysiology. --- Metabolism --- Disorders. --- Metabolism. --- Physiological aspects. --- Vitamins --- Orthomolecular therapy --- Psychiatry, Physiological --- Psychological manifestations of general diseases --- Psychophysiology --- Neurobehavioral dysfunction --- Neuropsychiatric disorders --- Organic brain syndromes --- Organic mental disorders --- Brain --- Sulfur amino acids --- Therapeutic use --- Diseases