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This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.

Cell nuclei. --- Mammals -- Cytology. --- Microscopy. --- Cell nuclei --- Cytology --- Biology --- Health & Biological Sciences --- Molecular biology. --- Cytology. --- Cell biology --- Cellular biology --- Molecular biochemistry --- Molecular biophysics --- Cell nucleus --- Nucleus (Cells) --- Medicine. --- Medical genetics. --- Cell biology. --- Cell physiology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Gene Function. --- Cell Physiology. --- Cells --- Cytologists --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cell organelles --- Cell function --- Physiology --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Genetic aspects --- Biomedicine, general. --- Health Workforce

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Mathematical statistics --- Expert systems (Computer science) --- Computer Science --- Mathematical Statistics --- Mathematics --- Engineering & Applied Sciences --- Physical Sciences & Mathematics --- Data processing --- Computer science. --- Computer programming. --- Computers. --- Database management. --- Information storage and retrieval. --- Artificial intelligence. --- Computer Science. --- Database Management. --- Artificial Intelligence (incl. Robotics). --- Programming Techniques. --- Information Systems Applications (incl. Internet). --- Information Storage and Retrieval. --- Computation by Abstract Devices. --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Calculators --- Cyberspace --- Computers --- Electronic computer programming --- Electronic digital computers --- Programming (Electronic computers) --- Coding theory --- Informatics --- Science --- Programming --- Information storage and retrieva. --- Artificial Intelligence. --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Application software. --- Application computer programs --- Application computer software --- Applications software --- Apps (Computer software) --- Computer software

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Mathematical statistics --- Expert systems (Computer science) --- Mathematical Statistics --- Mathematics --- Physical Sciences & Mathematics --- Data processing --- Computer science. --- Computers. --- Mathematical statistics. --- Database management. --- Information storage and retrieval. --- Artificial intelligence. --- Pattern recognition. --- Computer Science. --- Database Management. --- Artificial Intelligence (incl. Robotics). --- Theory of Computation. --- Information Storage and Retrieval. --- Probability and Statistics in Computer Science. --- Pattern Recognition. --- Information theory. --- Information storage and retrieva. --- Optical pattern recognition. --- Artificial Intelligence. --- Optical data processing --- Pattern perception --- Perceptrons --- Visual discrimination --- Informatics --- Science --- Communication theory --- Communication --- Cybernetics --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Computer systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Design perception --- Pattern recognition --- Form perception --- Perception --- Figure-ground perception --- Statistical inference --- Statistics, Mathematical --- Statistics --- Probabilities --- Sampling (Statistics) --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Calculators --- Cyberspace --- Statistical methods