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Biologie --- 573.2 --- DNA --- biologie --- moleculaire biologie* --- Cel- en weefselleer --- Moleculaire biologie. --- moleculaire biologie --- Molecular biology

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The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.

History of human medicine --- Immunology. Immunopathology --- immunologie --- farmacologie --- Cell receptors. --- Cell receptors --- Physiological effect. --- Receptors cel·lulars

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This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.

Histology. Cytology --- Immunology. Immunopathology --- immunologie --- cytologie --- histologie --- Immunology. --- Immune system. --- Cellular signal transduction. --- Cytology. --- Autoimmunity. --- Immunospecificity. --- Immune Cell Signalling. --- Cell Biology. --- Adaptive Immunity. --- Fosfatidilinositols --- Immunitat cel·lular

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Celbiologie --- Celfysiologie --- Celstructuren --- 576 --- 573.2 --- Histologie --- Cells. --- 576.31 --- #WPLT:dd.Prof.Vanlaere --- #WPLT:kand --- #WPLT:syst --- biologie --- DNA --- celbiologie --- celdeling --- cellen --- 57 --- 575.8 --- 576.3 --- 600.51 --- Bio-energetica --- Cytosol --- DNA deoxyribonucleic acid --- Eiwitsynthese --- Meiose --- Membranen --- Mitose --- Ribosomen --- biofysica --- celfysiologie --- celleer --- cytologie --- differentiatie celleer --- evolutie --- genetica --- genetische manipulatie --- histologie --- membranen --- metabolisme --- moleculaire biologie --- organellen --- translatie --- Biologie --- Cel --- Cytologie (celleer) --- Membraan --- anatomie --- biochemie --- fysiologie --- microbiologie --- Cell --- 576.31 Cell morphology --- Cell morphology --- 576 Cellular and subcellular biology. Cytology --- Cellular and subcellular biology. Cytology --- Cel- en weefselleer --- Anatomie - Cel- en weefselleer --- Cell Biology --- Biologie: cellen --- membranen (biologie) --- Histology. Cytology --- celprocessen --- Cells --- fotosynthese

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1. Hals: spieren, bloedvaten, zenuwen, ingewanden en topografische anatomie.2. Thorax: ruimten, organen, bloedvaten, lymfatisch systeem en zenuwstelsel3. Abdomen: ruimten, organen, bloedvaten, lymfatisch systeem en zenuwstelsel

Anatomy --- Anatomie --- Anatomy. --- 600.51 --- anatomie --- bekken --- biologie --- buik --- hals --- inwendige organen --- thorax --- 599.6 --- anatomie (ontleedkunde) --- Anatomies --- Anatomie - Cel- en weefselleer --- (zie ook: histologie) --- Anatomie. --- ademhalingsstelsel --- circulatiestelsel --- spijsverteringsstelsel --- spieren --- embryologie (biologie) --- lymfeknoop --- strottenhoofd --- keel --- schildklier --- zenuwen --- bloedvaten --- Human anatomy