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The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood-brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. .

Biology --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- medische biochemie --- farmacologie --- biologie --- biomedische wetenschappen --- Absorption (Physiology)

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This book addresses the impact of soil and water quality on food production, and explores soil and water conservation measures to be applied at farm level for agricultural sustainability. Divided into 8 chapters, the book covers topics such as soil properties responsible for soil loss, the impact of climate change, water and biological factors on soil chemistry, the effect of soil on the quality of water including sustaining aquaculture productivity and environment of wetlands, soil and water qualities necessary for irrigation, management of soil organic carbon, and the importance of soil moisture conservation including agroforestry for food production. Particular attention is given to the management of soil organic carbon in sustainable crop cultivation as well as reducing soil erosion and nutrient loss from soil from cultivated lands. The book concludes with a chapter that integrates soil and water conservation with sustainable food production and food safety.

Chemistry --- Hydrosphere --- Water supply. Water treatment. Water pollution --- Pedology --- Agriculture. Animal husbandry. Hunting. Fishery --- Food science and technology --- bodemkunde --- hydrologie --- chemie --- landbouw --- water --- voedingsleer --- Crops and soils. --- Soil absorption and adsorption. --- Soil moisture conservation.

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Experimental atomic and molecular physics --- spectroscopie --- Ultraviolet spectroscopy --- Spectroscopie ultraviolette --- Spectroscopie --- 543.4 --- AAS (atomaire absorptie spectrometrie) --- PHOTOMETERS --- SPECTROPHOTOMETERS --- Spectrum analysis. --- UV - VIS --- Atomic spectroscopy --- Molecular spectroscopy --- Optical spectroscopy --- Analysis, Spectrum --- Spectra --- Spectrochemical analysis --- Spectrochemistry --- Spectroscopy --- Chemistry, Analytic --- Interferometry --- Optics --- Radiation --- Wave-motion, Theory of --- Absorption spectra --- Light --- Spectroscope --- Qualitative --- Monograph --- Spectrometry

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Physicochemistry --- Spectrometric and optical chemical analysis --- moleculen --- spectroscopie --- moleculaire biologie --- fysicochemie --- spectrometrie --- Molecular biology --- Spectrum analysis --- Analysis, Spectrum --- Spectra --- Spectrochemical analysis --- Spectrochemistry --- Spectrometry --- Spectroscopy --- Analytical chemistry --- Interferometry --- Optics --- Radiation --- Wave-motion, Theory of --- Absorption spectra --- Light --- Spectroscope --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Qualitative

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The European Journal of Pharmaceutical Sciences is the official journal of the European Federation for Pharmaceutical Sciences (EUFEPS). The journal publishes research reports, review articles and scientific commentaries on all aspects of the pharmaceutical sciences with strong emphasis on originality and scientific quality. The Editors welcome articles in this multidisciplinary field, ranging from drug discovery, over drug delivery to drug development. More specifically, the Journal publishes reports in medicinal chemistry, pharmacology, drug absorption and metabolism, pharmacokinetics and pharmacodynamics, pharmaceutical and biomedical analysis, drug delivery including gene delivery, drug targeting, pharmaceutical technology, pharmaceutical biotechnology and clinical drug evaluation.

Pharmacology. Therapy --- Drugs --- Pharmacokinetics --- Technology, Pharmaceutical --- Pharmacology, Experimental --- Pharmaceutical chemistry --- Pharmacologie expérimentale --- Pharmacocinétique --- Chimie pharmaceutique --- periodicals. --- Periodicals. --- Periodicals --- Périodiques --- Chemistry, Pharmaceutical. --- Pharmaceutical Preparations. --- Pharmacokinetics. --- Technology, Pharmaceutical. --- Pharmacology, Experimental. --- Périodiques. --- Chemistry --- Engineering --- Health Sciences --- Life Sciences --- Analytical Chemistry --- Medicinal Chemistry --- Pharmaceutical Technology --- Pharmacy and Pharmacology --- Metabolism --- Pharmazie --- Zeitschrift --- Pharmaceutical Preparations --- Pharmacologie expérimentale --- Pharmacocinétique --- Périodiques --- EJPHARM ELSEVIER-E EPUB-ALPHA-E EPUB-PER-FT MDPHARMA --- MDPHARMA --- farmacologie --- drug delivery --- pharmacokinetics --- pharmacodynamics --- pharmaceutical --- biomedical analysis --- Chemistry, Pharmaceutical --- Experimental pharmacology --- Therapeutics, Experimental --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Chemistry, Medicinal --- Pharmaceutic Technology --- Pharmacy Technology --- Technology, Pharmaceutic --- Technology, Pharmacy --- Drug Industry --- Periodikum --- Zeitschriften --- Presse --- Fortlaufendes Sammelwerk --- Arzneikunde --- Arzneimittelkunde --- Pharmakologie --- Apotheker --- ADME --- ADME-Tox --- ADMET --- Absorption, Distribution, Metabolism, Elimination, and Toxicology --- Absorption, Distribution, Metabolism, and Elimination --- Drug Kinetics --- Kinetics, Drug --- LADMER --- Liberation, Absorption, Distribution, Metabolism, Elimination, and Response --- Pharmaceutic Preparations --- Pharmaceutical Products --- Pharmaceuticals --- Preparations, Pharmaceutical --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Preparations, Pharmaceutic --- Product, Pharmaceutical --- Products, Pharmaceutical --- Pharmacology --- Drug Dosage Calculations --- pharmacokinetics --- Pharmaceutical chemistry. --- Pharmaceutical technology. --- Drugs. --- Chimie pharmaceutique. --- Pharmacocinétique. --- Techniques pharmaceutiques. --- Médicaments. --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology --- Drug kinetics --- Kinetics, Drugs --- Chemical kinetics --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Kinetics --- Pharmaceutical technology