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This book provides a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals as well as the technological strategies that have been followed so far regarding the optimization of mucosal potentialities. The book also addresses the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration. After a brief introduction, the first section addresses general aspects of the biology of mucosal tissues and their unique aspects towards beneficial or deleterious interactions with biopharmaceuticals and delivery systems. The second part is dedicated to the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications, either factual or potential, of particular pharmaceutical delivery systems and products enclosing biopharmaceuticals for mucosal delivery. Special focus is set on the most successful case studies of recent years by field experts or those engaged in developing such solutions in a concise and practical way. The last section briefly centers on pertinent aspects about the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals.   José das Neves is a researcher at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, and in the Faculty of Pharmacy, University of Porto, Portugal, where he earned a Ph.D. in Pharmaceutical Sciences. His previous work has spanned multiple aspects of the development of vaginal drug delivery systems, and his current research interests include the development of nanotechnology-based solutions for the development of anti-HIV microbicides and mucosal delivery of biopharmaceuticals.   Bruno Sarmento is an affiliated researcher at INEB – Instituto de Engenharia Biomédica, University of Porto, Portugal. He is also an assistant professor of pharmaceutical and biopharmaceutical technology at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal. He earned a Ph.D. in Pharmaceutical Technology at the University of Porto. He has extensive work in the development of nanocarriers for the oral delivery of biopharmaceuticals—namely insulin—and the establishment of novel in vitro intestinal permeability models. His current research focuses on nanomedicines and their applications in the pharmaceutical and biomedical fields.

Toxicology --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- klinische chemie --- medische biochemie --- farmacologie --- biogeneesmiddelen --- biochemie --- biomedische wetenschappen --- multimedia --- toxicologie

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The book presents a compilation of studies regarding applied geomechanics, mining, and excavation analysis and simulation. The material is suitable for presentation to senior undergraduate and post-graduate students in both mining and geological engineering. It should also be of interest to students of other aspects of Geomechanics and, notably, engineering geologists interested in mining and underground excavation design. Practising mining engineers and rock mechanics engineers involved in mine design may use the book profitably to obtain an appreciation of the current state of engineering knowledge in their area of specialisation. Papers were selected from the 5th GeoChina International Conference on Civil Infrastructures Confronting Severe Weathers and Climate Changes: From Failure to Sustainability, held in July 23-25, 2018 in Hang Zhou, China.

Meteorology. Climatology --- Hydraulic energy --- Mining industry --- Artificial intelligence. Robotics. Simulation. Graphics --- Structural parts and elements of building --- opwarming (milieu) --- funderingen --- duurzame energie --- duurzaamheid --- vormgeving --- mineralen (chemie) --- simulaties --- mijnbouw --- KI (kunstmatige intelligentie) --- hydraulica --- klimaatverandering --- AI (artificiële intelligentie)

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The13thPortugueseConferenceonArti?cialIntelligence,EPIA2007,tookplace in the old city of Guimara ˜es and was sponsored by the University of Minho and APPIA, the Portuguese Association for Arti?cial Intelligence. The city of Guimaraes ˜ is classi?ed as a UNESCO World Cultural Heritage, being located in the North of Portugal,in the Minho Region,approximately350 Km northof the capital,Lisbon,andabout50Kmfromthesecondlargestcity,thecityofOporto. Guimara ˜es has its origin in times previous to the foundation of the Portuguese nationality, the place where Portugal was born in the twelveth century. It is proudly referred to as the Cradle of the Nation. EPIA was ?rstly held in the city of Oporto, in 1985. Its purpose was to promote the research in arti?cial intelligence (AI) and the scienti?c exchange among AI researchers, practitioners, scientists and engineers. The conference is devoted to all areas of arti?cial intelligence and covers both theoretical and foundational issues as well as applications. As in previous editions, the program wasprearrangedintermsofworkshopsdedicatedtospeci?cthemesofAI,invited lectures, tutorials and sessions, all selected according to the highest standards. Theprogramoftheconferenceincludedforthe?rsttimeaDoctoralSymposium. A total of 11 workshops were considered, following the guidelines of the - ganizing and Advisory Committees. The list includes workshopsheld in the p- vious edition, such as GAIW, BAOSW07, IROBOT07, MASTA07, TEMA07, and ALEA, rearrangements of previous ones, such as CMBSB, and novel ones such as AIASTS, AmITA, BI07 and STCS.

Computer science --- Programming --- Information systems --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- IR (information retrieval) --- informatica --- programmeren (informatica) --- database management --- robots

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The book presents the recent advances on testing and experimentation in civil engineering, especially in the branches of geotechnics, transportation, hydraulics, and natural resources. It includes advances in physical modelling, monitoring techniques, data acquisition and analysis, and provides an invaluable contribution for the installation of new civil engineering experimental facilities. The first part of the book covers the latest advances in testing and experimentation in key domains of geotechnics: soil mechanics and geotechnical engineering, rock mechanics and rock engineering, and engineering geology. Some of the topics covered include new developments in topographic survey acquisition for applied mapping and in situ geotechnical investigations; laboratory and in situ tests to estimate the relevant parameters needed to model the behaviour of rock masses and land structures; monitoring and inspection techniques designed for offshore wind foundations. The second part of the book highlights the relevance of testing and monitoring in transportation. Full-scale accelerated pavement testing, and instrumentation becomes even more important nowadays when, for sustainability purposes, non-traditional materials are used in road and airfield pavements. Innovation in testing and monitoring pavements and railway tracks is also developed in this part of the book. Intelligent traffic systems are the new traffic management paradigm, and an overview of new solutions is addressed here. Finally, in the third part of the book, trends in the field and laboratory measurements and corresponding data analysis are presented according to the different hydraulic domains addressed in this publication, namely maritime hydraulics, surface water and river hydraulics and urban water. .

Hydraulic energy --- Mining industry --- Transport. Traffic --- Building materials. Building technology --- verkeer --- mijnbouw --- transport --- bouwmaterialen --- hydraulica

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This book gathers the peer-reviewed selected papers presented at the 3rd International Conference on Testing and Experimentation in Civil Engineering (TEST&E 2022), held in Almada, Portugal, on June 21-23, 2022. It showcases the role of smart technologies in all civil engineering areas, such as structures and construction, geotechnics and natural resources, hydraulics and water resources, transportation and communication networks. The conference topics encompass big data and advanced data processing systems, AI applications, virtual and augmented reality, 3D modeling and printing, digital twins, automation, sensing and detection technologies, inspection, monitoring and automatic damage identification, destructive and non-destructive testing, bio, nano and new materials, disaster risk reduction and emergency management. As such the book represents an invaluable, up-to-the-minute tool, and offers an important platform to engineers and architects.

Applied physical engineering --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- Civil engineering. Building industry --- computervisie --- grafische vormgeving --- ingenieurswetenschappen