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Immune response --- Peptides --- Proteins --- Regulation --- Congresses. --- Immunology --- Congresses --- ANTIBODY FORMATION --- PROTEINS --- PEPTIDES --- IMMUNOLOGY

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Antigen-antibody complex --- Complement activating enzymes --- Complement --- Complement activation. --- Igg --- Macrophages --- Receptors --- Immunology. --- Metabolism.

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Epidermolysis Bullosa Acquisita --- Skin --- Skin Diseases, Vesiculobullous --- Cell Adhesion Molecules --- Autoantibodies --- Fluorescent Antibody Technique, Indirect. --- Fluorescent Antibody Technic, Indirect --- Immunofluorescence Technic, Indirect --- Indirect Fluorescent Antibody Technic --- Indirect Fluorescent Antibody Technique --- Indirect Immunofluorescence --- Indirect Immunofluorescence Assay --- Immunofluorescence Antibody Test, Indirect --- Immunofluorescence Technique, Indirect --- Assay, Indirect Immunofluorescence --- Assays, Indirect Immunofluorescence --- Immunofluorescence Assay, Indirect --- Immunofluorescence Assays, Indirect --- Immunofluorescence Technics, Indirect --- Immunofluorescence Techniques, Indirect --- Immunofluorescence, Indirect --- Immunofluorescences, Indirect --- Indirect Immunofluorescence Assays --- Indirect Immunofluorescence Technic --- Indirect Immunofluorescence Technics --- Indirect Immunofluorescence Technique --- Indirect Immunofluorescence Techniques --- Indirect Immunofluorescences --- diagnosis. --- ultrastructure. --- immunology. --- analysis. --- Theses --- Fluorescent Antibody Technique, Indirect --- diagnosis --- ultrastructure --- immunology --- analysis

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Antibodies, Monoclonal. --- Monoclonal Antibodies --- Hybridomas --- Monoclonal antibodies. --- Hybridomas. --- Immunology. Immunopathology --- Monoclonal antibodies --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Myeloma-spleen cell hybrids --- Clone cells --- Lymphocytes --- Plasmacytoma --- Somatic hybrids --- Anticorps monoclonaux --- Addresses, essays, lectures --- Monoclonal Antibody --- Antibody, Monoclonal

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1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2. 1 Functions. . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2 Binding. . . . . . . . . . . . . . . . . . . . . . . . . 3 3 Intracellular Processing - Cleavage and Reduction . . . . . . 4 3. 1 Cytosolic Activity . . . . . . . . . . . . . . . . 5 4 Immunotoxin Design and Testing. 6 5 Conclusion. . 8 References. . . . . 8 1 Introduction While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-func­ tion relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins. Bacterial and plant toxins (e. g. , diphtheria toxin, Pseudomonas exotoxin and ricin) are among the most toxic substances known. However, because they bind to cell surface receptors that are present on most normal cells, unmodified toxins are generally useless as anti-cancer agents. To convert toxins into more selective agents, their binding domains are either eliminated or disabled and replaceq with cell­ binding antibodies that are tumor-selective.

Farmacologie [Immuno] --- Immunofarmacologie --- Immunopharmacologie --- Immunopharmacology --- Pharmacoimmunology --- Pharmacologie [Immuno] --- Immunotoxins --- Diphtheria toxin --- Ricin --- therapeutic use --- pharmacology --- therapeutic use. --- pharmacology. --- Therapeutic use. --- Pharmacology. --- Antibody-toxin conjugates --- Therapeutic use --- Immunology. --- Cancer research. --- Hematology. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Haematology --- Internal medicine --- Blood --- Cancer research --- Immunobiology --- Life sciences --- Serology --- Physiological effect --- Diseases --- Antibody-toxin conjugates. --- Conjugates, Antibody-toxin --- Immunoconjugates --- Immunoglobulin-toxin conjugates --- Toxin-antibody conjugates --- Toxin-immunoglobulin conjugates --- Bioconjugates --- Immunotoxicology --- Toxins