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Book
Cocrystal Applications in Drug Delivery
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In 2015, the first pharmaceutical cocrystal was approved by the FDA. Since then, the number of cocrystals on the market and in the development pipeline has been slowly but steadily growing. It is now well established that cocrystals are a versatile new approach to oral drug formulation. This Reprint Book is a collection of articles that show the utility of pharmaceutical cocrystals and various aspects of cocrystal research: • Cocrystals as a strategy to modify the physicochemical properties of a drug such as dissolution behaviour, tabletability, and melting point; • Development of new coformers; • Screening studies for multiple cocrystal forms; • Cocrystals in nano-sized drug delivery.


Book
Wastewater Treatment, Valorization and Reuse
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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This book deals with the latest developments regarding urban and industrial wastewaters’ adapted treatment with various technologies. It focuses, through valuable publications, on the shifting of the wastewater management paradigm from “treatment and disposal” to “the 4Rs principle: Reduce, Recycle, Reuse, and Recover”. The adapted wastewater treatment step will allow (i) the disposal of supplementary water amounts that could be safely reused in order to tackle the water-scarcity problem, and (ii) the preservation of the environment against pollution. Finally, this book will contribute to the achievement of the United Nations Sustainable Development Goals and other international related initiatives.


Book
Advances in Nanoparticles: Synthesis, Characterization, Theoretical Modelling, and Applications
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ISBN: 3039285831 3039285823 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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This book focuses on recent advances in the synthesis of nanoparticles, their characterization, and their applications in different fields such as catalysis, photonics, magnetism, and nanomedicine. Nanoparticles receive a large share of the worldwide research activity in contemporary materials science. This is witnessed by the number of scientific papers with ""nanoparticle"" as a keyword, increasing linearly in the last 10 years from about 16,000 in 2009 to about 50,000 in 2019. This impressive widespread interest stems from the basic science of nanoparticles, which constitute a bridge between the molecular and the bulk worlds, as well as from their technological applications. The preparation of nanoparticles is a crossroad of materials science where chemists, physicists, engineers, and even biologists frequently meet, leading to a continuous improvement of existing techniques and to the invention of new methods. The reader interested in nanoparticles synthesis and properties will here find a valuable selection of scientific cases that cannot cover all methods and applications relevant to the field, but still provide an updated overview on the fervent research activity focused on nanoparticles.


Book
Polymers Enhancing Bioavailability in Drug Delivery
Authors: ---
ISBN: 3036556834 3036556842 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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This Special Issue provides an update on the state of the art and current trends in polymeric drug-delivery systems specifically designed for improving drug bioavailability. The multiple contributions received further strengthen the role of polymers in modern drug delivery and targeting, illustrating the different approaches possible and unveiling what the future may bring.

Keywords

Medicine --- Pharmaceutical industries --- cystic fibrosis --- Pseudomonas aeruginosa --- liposomes --- efflux pump inhibitor --- PABN --- aminoglycosides --- macrolides --- poloxamer --- thiourea --- thiolation --- mucoadhesion --- drug release --- in vivo analysis --- in vitro dissolution studies --- S-propargyl-cysteine --- poly(lactic acid) --- endogenous hydrogen sulfide --- water-in-oil-in-water --- rheumatoid arthritis --- chitosan --- drug delivery --- drug absorption --- intestinal assimilation --- oral bioavailability --- nanoemulsions --- micelles --- SEDDS --- zeta potential --- sustained release --- albumin nanoparticle --- MPT0B291 --- high-pressure homogenizer --- histone deacetylase --- calix[8]arenes --- silibinin --- inclusion complexes --- PEGylation --- cytotoxicity --- oromucosal films --- sodium alginate --- nanoparticle drug carriers --- digoxin --- zein --- heart failure --- polymer–liposome complexes --- Pluronic®-poly(acrylic acid) --- Pluronic®-poly(N,N-dimethylaminoethyl methacrylate) --- stimuli-responsive --- intelligent drug delivery systems --- liposome --- polymer --- long circulation --- polymer–lipid conjugates --- targeting --- stimulus-responsive --- antibody --- affinity --- cyclodextrin --- protein therapeutics --- sustained drug delivery --- Nitric oxide --- hydrogel --- wound dressing --- chronic wounds --- glycyrrhetinic acid --- Soluplus® --- solid dispersions --- anti-inflammatory --- biosafety --- bioavailability --- n/a --- polymer-liposome complexes --- polymer-lipid conjugates


Book
Analysis, Design and Fabrication of Micromixers
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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This book includes an editorial and 12 research papers on micromixers collected from the Special Issue published in Micromachines. The topics of the papers are focused on the design of micromixers, their fabrication, and their analysis. Some of them proposed novel micromixer designs. Most of them deal with passive micromixers, but two papers report studies on electrokinetic micromixers. Fully three-dimensional (3D) micromixers were investigated in some cases. One of the papers applied optimization techniques to the design of a 3D micromixer. A review paper is also included and reports a review of recently developed passive micromixers and a comparative analysis of 10 typical micromixers.

Keywords

passive micromixers --- comparative analysis --- Navier-Stokes equations --- mixing index --- pressure drop --- mixing cost --- micromachining --- micro EDM milling --- empirical modelling --- micromixer --- design for manufacturing --- computational fluid dynamics --- micromixers --- acoustic micromixers --- active micromixers --- electromagnetic micromixers --- voice-coil mixers --- mixers --- anti-reciprocity --- electrical impedance --- mechanical velocity --- gyrator --- electro-mechanical systems --- micro heat exchanger --- vortex shedding --- thermal mixing --- computational fluid dynamics (CFD) --- thermal engineering --- three-dimensional (3D) printing --- micronozzles --- Y-shaped structure --- mixing efficiency --- histogram and standard deviation --- split-and-recombine --- additive manufacturing --- surface metrology --- asymmetric split-and-recombine (ASAR) --- stereolithography --- surface roughness --- soft tooling --- centrifugal microfluidics --- U-shaped channel --- Coriolis force --- flow visualization --- microfluidics --- T-shaped micromixer --- vortex --- obstacles --- engulfment flow --- particle tracking --- electrokinetic vortices --- T-type microchannel --- zeta potential ratio --- length ratio --- Navier–Stokes equations --- optimization --- RBNN --- TLCCM configuration --- mixing rate --- kinematics --- deformation --- vorticity --- stretching --- folding --- diffusive mixing --- passive mixing --- fluid overlapping --- sequential injection --- segmentation --- concentric flow --- CFD --- n/a


Book
Fabrication of Carbon and Related Materials/Metal Hybrids and Composites
Authors: --- --- ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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This Special Issue on “Fabrication of Carbon and related materials/ Metal Hybrids and Composites” presents the importance of the development of new composite and hybrid materials in different fields. It consists of 17 articles contributed by authors from different countries all over the world. The articles can be categorized into four classes. The first class of includes articles focusing on the synthesis of carbon fibers, carbon nanotubes, and graphene hybrid and composite materials. The results include the developments of the methodology and know-how of the synthesis and functionalization of the graphene surface of fibers and nanotubes and their effects on binding with the metal matrix. The second class focuses on the synthesis of new polymeric materials based on pitch/polyethylene composites and their electrical and mechanical properties, including the correlations with its microstructures. Additionally, the second class presents the results of articles, including the synthesis of new biocompatible and eco-friendly metal oxide/polymer materials with antibacterial and antimicrobial activities. The third class includes articles focused on the applications of ceramic metal oxides, such as silica and clays in the development of solar cells and in the fabrications of membranes of water treatments and desalinations. The last part of this Special Issue presents results of the articles focused on high-entropy alloys and metal matrix composites and their weldability.

Keywords

carbon long fibers --- copper composites --- electroless copper deposition --- electroless silver deposition --- copper electroplating --- contact electrical resistivity --- ultrafiltration --- red clay --- calcium fluoride powder --- wastewater --- oil separation --- ZnO nanoparticles --- green synthesis --- cytotoxicity --- anticancer activity --- chemotherapeutic drugs --- doxorubicin --- gemcitabine --- MDA-MB 231cell line --- triple-negative breast cancer treatment --- high entropy alloys --- electroless copper plating --- thermal expansion --- hardness --- compressive strength --- direct friction stir processing --- in situ composites --- surface composites --- TES --- PCM --- paraffin wax --- multi-walled CNTs --- SEM --- EDX --- TGA --- FTIR --- indentation --- room temperature --- liquid nitrogen temperature --- spalling --- Si-NWs --- nanoscale chemical templating (NCT) --- PV --- copper --- nanocomposites --- metal-matrix composites (MMCs) --- mechanical properties --- spark plasma sintering --- hybrid materials --- chemical precipitation --- Carbopol --- BET surface area --- zeta-potential --- antibacterial activity --- mesophase-pitch --- polyethylene --- carbon-fibres --- morphology --- winder --- blend --- hot pressing --- aluminum matrix composites --- electroless silver and nickel precipitation --- wear resistance --- graphene --- silica --- hybrid composites --- adsorbents --- energy storages --- biomedical fields --- catalysts --- chemical vapor deposition (CVD) --- silicon (Si) --- nanowires (NWs) --- silica microspheres --- photovoltaic (PV) cells --- copper-zinc alloy --- graphene nanosheets --- microstructure --- electrical conductivity --- thermal conductivity --- wear rate --- extrusion --- dwell time --- mesophase pitch --- mixed CNT bundle --- crosstalk delay --- interconnect --- propagation delay --- RLC model --- nanodecoration --- first-principles calculations --- adsorption --- CO2 electroreduction


Book
Micro/Nano-Chip Electrokinetics, Volume III
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Micro/nanofluidics-based lab-on-a-chip devices have found extensive applications in the analysis of chemical and biological samples over the past two decades. Electrokinetics is the method of choice in these micro/nano-chips for transporting, manipulating, and sensing various analyte species (e.g., ions, molecules, fluids, and particles). This book aims to highlight the recent developments in the field of micro/nano-chip electrokinetics, ranging from the fundamentals of electrokinetics to the applications of electrokinetics to both chemo- and bio-sample handling.

Keywords

electrokinetic micromixer --- induced-charge electroosmosis --- field-induced Debye screening --- AC field-effect flow control --- electrochemical ion relaxation --- Electroosmosis --- Power-law fluid --- Non-Newtonian fluid --- Asymmetric zeta potential --- organ-on-a-chip --- biosensors --- biomedical --- microfluidics --- in vivo models --- applications --- Microfilter --- Dielectrophoresis --- Particle separation, micropillar --- multi-layer structure --- electroosmotic flow (EOF) pump --- parallel fluid channels --- liquid metal electrodes --- microfluidic particle concentrator --- continuous and switchable particle flow-focusing --- composite electrode arrangement --- field-effect flow control --- multifrequency induced-charge electroosmosis --- simultaneous pumping and convective mixing --- dual-Fourier-mode AC forcing --- traveling-wave/standing-wave AC electroosmosis --- bacteriophage --- dielectrophoresis --- electric field --- electrophoresis --- electrokinetics --- virus --- time-periodic electroosmotic flow --- heterogeneous surface charge --- cylindrical microchannel --- stream function --- micro-mixing --- cross-membrane voltage --- ion concentration polarization --- desalination effect --- pump effect --- eddy current --- electroosmotic flow --- viscoelastic fluid --- nanofluidics --- ionic conductance --- electrical double layer --- droplet --- electrohydrodynamics --- phase field method --- non-uniform electric field --- Linear Phan-Thien–Tanner (LPTT) --- pH --- tunable focus --- liquid lens --- charge injection --- characterization --- carbon electrodes --- three-dimensional (3D) --- diagnostics --- Candidiasis --- n/a --- Linear Phan-Thien-Tanner (LPTT)


Book
Development of Unconventional Reservoirs
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ISBN: 3039285815 3039285807 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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The need for energy is increasing and but the production from conventional reservoirs is declining quickly. This requires an economically and technically feasible source of energy for the coming years. Among some alternative future energy solutions, the most reasonable source is from unconventional reservoirs. As the name “unconventional” implies, different and challenging approaches are required to characterize and develop these resources. This Special Issue covers some of the technical challenges for developing unconventional energy sources from shale gas/oil, tight gas sand, and coalbed methane.

Keywords

horizontal well --- shale gas --- shock loads --- pseudo-steady-state non-equilibrium sorption --- unsteady state non-equilibrium sorption --- porosity–permeability --- fractured-vuggy reservoirs --- flow channel --- pressure derivative --- total organic carbon (TOC) --- CO2 huff-n-puff --- flow behavior --- unconventional reservoirs --- semi-analytical model --- gravel pack --- optimization measures --- fractures --- lab tests under reservoir condition --- dual-porosity system --- unconventional --- gravity differentiation --- MICP --- perforation safety --- fracture penetration extent --- organic-rich shale --- stress-dependent permeability --- equilibrium sorption --- helium porosimetry --- numerical model --- original gas in-place --- shale alteration --- injection and production pattern --- adsorption and desorption isotherms --- low-pressure gas adsorption --- initial water saturation --- drilling fluid --- sorption hysteresis --- coalbed methane --- gas content --- capillary number --- reorientation fractures --- water flooding effect --- organic pores --- tight reservoir --- condensate recovery --- Langmuir pressure --- Klinkenberg slippage theory --- limestone and calcareous mudstone interbedding --- petrophysics --- tight gas sand --- numerical analysis --- northern Guizhou --- wettability --- peak pressure --- sand control --- water imbibition --- clay bound water --- carbon dioxide sequestration --- adsorption capacity --- gas compressibility factors --- convolutional neural network --- multi-stage fracturing horizontal wells --- fractured tight reservoir --- physical model --- tight gas reservoirs --- automatic classification --- NMR --- catalytic oxidation characteristics --- micro-CT image --- wellbore stability --- gas adsorption and desorption --- gas shale --- medium volatile bituminous coal --- hydraulic flow units --- GEM® --- petrophysical properties --- compositional 3D --- rock-water-CO2 interaction --- source-mixed gas --- residual gas distribution --- oxidation reaction pathway --- coal rank --- oil migration --- clay content --- perforated string --- TOC recovery --- Computer Modelling Group (CMG) --- capillary trapping --- pore size distribution --- adsorption --- tight reservoirs --- well interference --- gradation optimization --- shale gas condensate reservoir --- Niutitang formation --- pulse decay test --- well testing --- Langmuir model --- methane adsorption capacity --- pore structure --- and tight sand gas) --- ultra-deep well --- deepwater well --- orthogonal test --- high pressure and low flowrate --- theoretical model --- safety analysis --- transient pressure --- catalyst-activated low temperature oxidation --- reservoir simulation --- Langmuir volume --- air flooding --- petrography --- total organic carbon --- electrical resistivity --- diffusion coefficient --- equation of state --- porosity --- zeta potential --- gas permeability measurement --- co-exploitation --- nuclear magnetic resonance --- Changqing tight oil --- visual experiment --- tight oil reservoirs --- caprock integrity --- coal measure gases (coalbed gas --- NIST-Refprop


Book
High Performance Concrete
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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The innovations in construction materials that have been made due to the development of different varieties of concrete have led to innovations in structural applications and design. This Special Issue mainly focuses on state-of-the-art research progress in high-performance concrete, including the effect and characteristics of fibers on the properties of high-performance concrete, the CO2 curing efficiency of high-performance cement composites, and the effect of nano materials when used in ultra-high-performance concrete. This Special Issue also contains two comprehensive review articles covering the following topics: the role of supplementary cementitious materials in ultra-high-performance concrete and recent progress in nanomaterials in cement-based materials. Readers working towards conducting research on innovative construction materials will be exposed to findings related to this topic in this Special Issue.

Keywords

ultrahigh-performance concrete --- nanosilica --- dynamic light scattering --- zeta potential --- pore solution --- alkali-activator --- GGBFS --- Na2O content --- Ms (SiO2/Na2O) --- workability --- setting time --- steel fiber --- fiber content --- aspect ratio --- toughness index --- high-strength concrete --- fibers --- smart materials --- fiber/matrix bond --- physical properties --- heat treatment --- alkali-activated material --- calcium sulfoaluminate-based expansive additive --- concrete shrinkage --- modulus of elasticity --- shrinkage stress --- SIFRCC --- fiber volume fraction --- direct tensile strength --- energy absorption capacity --- direct tensile test --- carbon nanotubes --- cement-based materials --- concrete infrastructure --- graphene --- graphene oxide --- mechanical strength --- nanomaterials --- nano-Al2O3 --- nano-Fe2O3 --- nano-SiO2 --- nano-TiO2 --- smart infrastructure --- slurry-infiltrated fiber-reinforced cementitious composite --- high-performance fiber-reinforced cementitious composite --- compressive stress --- stress-strain relationship --- filling slurry matrix --- bio-slime --- sulfate attack --- chloride attack --- service life --- multi-layer diffusion --- repair --- concrete --- dynamic compression --- Split Hopkinson Pressure Bars (SPHB) --- brittle materials --- simulation --- calcined zeolite sand --- ultra-high-performance concrete --- pre-wetted --- autogenous shrinkage --- internal curing --- reactive powder concrete --- strength --- basalt fibers --- abrasion --- porosity --- microscopic image processing --- X-ray CT analysis --- porous cementitious materials --- 3D tomographic image --- CO2 curing --- size effect --- colloidal silica --- cement-based material --- casting method --- ultra-high performance fiber-reinforced concrete --- densified silica fume --- agglomeration --- pozzolanic reaction --- densification --- alternative alkali-activated material --- ground granulated blast-furnace slag --- strength development --- CSA expansive additive --- ultrasonic pulse velocity --- temperature --- high performance concrete (HPC) --- C-shape magnetic probe test --- fibre orientation angle --- flexural test --- attenuation factor --- ultra-high-performance steel fiber-reinforced concrete --- multiscale finite element modeling --- multi-point constraint --- multi-scale interface connection --- concrete damage plasticity model --- ABAQUS --- ultra high-performance concrete (UHPC) --- supplementary cementitious materials (SCMs) --- sustainability --- compressive strength --- flowability --- shrinkage --- railway sleeper --- static bending test --- numerical simulation --- structural performance --- high performance fiber reinforced concrete (HPFRC) --- polypropylene fiber (PP) --- polyvinyl alcohol fiber (PVA) --- residual flexural strength --- splitting tensile strength


Book
Emerging Trends in TiO2 Photocatalysis and Applications
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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The semiconductor titanium dioxide (TiO2) has been evolved as a prototypical material to understand the photocatalytic process, and has been demonstrated for various photocatalytic applications such as pollutants degradation, water splitting, heavy metal reduction, CO2 conversion, N2 fixation, bacterial disinfection, etc. Rigorous photocatalytic studies on TiO2 have paved the way to understanding the various chemical processes involved and the physical parameters (optical and electrical) required to design and construct diverse photocatalytic systems. Accordingly, it has been realized that an effective photocatalyst should have ideal band edge potential, narrow band gap energy, reduced charge recombination, enhanced charge separation, improved interfacial charge transfer, surface-rich catalytic sites, etc. As a result, many strategies have been developed to design a variety of photocatalytic systems, which include doping, composite formation, sensitization, co-catalyst loading, etc. Towards highlighting the above-mentioned diversities in TiO2 photocatalysis, there have been many interesting original research works on TiO2, involving material designs for various photocatalytic applications published in this Special Issue. In addition, some excellent review papers have also been published in this Special Issue, focusing on the various TiO2-based photocatalytic systems and their mechanisms and applications.

Keywords

modified L-H model --- N-TiO2 --- photocatalytic degradation --- benzene --- antibacterial --- copper oxide --- photocatalyst --- titanium dioxide --- thin film --- visible light --- photovoltaic conversion --- interfacial charge-transfer transition --- 7,7,8,8-tetracyanoquinodimethane --- Nb-doped TiO2 --- N-doped graphene quantum dots --- TiO2 --- photocatalytic performance --- pyridinic N --- graphitic N --- solid-phase photocatalytic degradation --- polyvinyl borate --- decahedral-shaped anatase titania particles --- {001} and {101} facets --- facet-selective metal photodeposition --- pH dependence --- zeta potential --- facet-selective reaction --- photocatalysis --- deNOxing --- Titania --- photophysics --- metal oxides --- environment --- 2D materials --- composite --- iron-doped TiO2 --- photocatalytic activity --- low UV irradiation --- hydroxyl radical --- estriol --- W-Mo dopants --- nanoparticles --- non-metal- doped TiO2 --- nitroaromatic compounds --- reduction --- selectivity --- Titanium dioxide --- bismuth molybdate --- lignin --- UV light --- Photo-CREC Water II reactor --- Palladium --- Hydrogen production --- Quantum Yield --- magnetic property --- reusable --- photoreduction --- microporous material --- adsorption --- air purification --- porous glass --- mesocrystals --- synthesis --- modification --- Ru-Ti oxide catalysts --- HCl oxidation --- oxygen species --- Ce incorporation --- active phase-support interactions --- bleached wood support materials --- 3D photocatalyst --- UV transmittance --- floatable --- recyclable --- TiO2C composite --- acid catalyst --- dehydration --- fructose --- 5-Hydroxymethylfurfural --- Microcystis aeruginosa --- microcystin --- controlled periodic illumination --- advanced oxidation process --- hexabromocyclododecane --- environmental management --- advanced oxidation processes --- energy band engineering --- morphology modification --- applications --- Titanium dioxide (TiO2) --- visible-light-sensitive photocatalyst --- N-doped TiO2 --- plasmonic Au NPs --- interfacial surface complex (ISC) --- selective oxidation --- decomposition of VOC --- carbon nitride (C3N4) --- alkoxide --- ligand to metal charge transfer (LMCT) --- hydrogen production --- TiO2-HKUST-1 composites --- solar light --- electron transfer --- graphene quantum dots --- heterojunction --- process optimization --- response surface methodology --- kinetic study --- Advanced oxidation processes (AOPs) --- TiO2 catalyst --- textile wastewater --- oxygen vacancy --- polymeric composites --- photoelectrochemistry --- co-modification --- solar energy conversion --- p-n heterojunction --- g-C3N4 --- charge separation --- semiconductors --- redox reactions --- band gap engineering --- nanostructures --- n/a --- in-situ formation --- anatase nanoparticles --- H-titanate nanotubes --- dual-phase --- low temperature

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