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Currently, aortic stenosis is the most frequent heart valve disease in developed countries and its prevalence increases with the aging of the population. Affecting 3-5 percent of persons older than 65 years of age, it makes a large personal and economical impact. The increasing number of elderly patients with aortic stenosis brings advances in all medical specialties dealing with this clinical entity. Patients previously considered too old or ill are now indicated for aortic valve replacement procedures. This book tries to cover current issues of aortic valve stenosis management with stress on new trends in diagnostics and treatment.

Aortic valve. --- Valva aortae --- Heart valves --- Endocrinology

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Much has evolved in the field of aortic valve disease because of the increase in knowledge in the last decade, especially in the area of its management. This book "Aortic Valve" is comprised of 18 chapters covering basic science, general consideration of aortic valve disease, infective endocarditis, aortic sclerosis and aortic stenosis, bioprosthetic valve, transcatheter aortic valve implantation and a special section on congenital anomalies of the aortic valve. We hope this book will be particularly useful to cardiologists and cardiovascular surgeons and trainees. We also believe that this book will be a valuable resource for radiologists, pathologists, cardiovascular anesthesiologists, and other healthcare professionals who have a special interest in treating patients with aortic valve disease. We are certain that information in this book will help to provide virtually most new areas of aortic valve disease that will be employed in the current era.

Aortic valve. --- Valva aortae --- Heart valves --- Cardiovascular medicine

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Calcific aortic valve stenosis --- clinical management --- prosthetic valves --- thrombosis --- biomarkers --- clinical imaging --- heart valve biology

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New challenges in water systems toward safety, efficiency, reliability, and system flexibility will be fundamental in the near future. In this book, readers can find different approaches that include safety analysis, system efficiency improvements, and new innovative designs. The risk function is a measure of its vulnerability level and security loss. Analyses of transient flows associated with the most dangerous operating conditions, are compulsory to grant system liability in terms of water quantity, quality, and system management. Specific equipment, such as air valves, is used in pressurized water pipes to manage the air inside, associated with the emptying and filling process. Advanced tools are developed toward near-future smart water grids. The water system efficiency and water–energy nexus, through the implementation of suitable pressure control and energy recovery devices, as well as pumped-storage hydropower, provide guidelines toward the most technical and environmental cost-effective solutions. Integrated analysis of water and energy allows more reliable, flexible, and sustainable eco-design projects, reaching better resilience systems. Hydraulic simulators and computational fluid dynamics (CFD), conjugating with field or experimental tests, supported by advanced smart equipment, allow a better design, control, and complex event anticipation occurrence to attain high levels of water system security and efficiency.

trunk network --- water distribution network --- resilience --- optimization --- energy recovery --- pumps as turbines --- water distribution networks --- EPANET --- safe water --- air valve --- CFD --- hydraulic characterization --- entrapped air --- safety of water supply consumers --- risk --- water supply system --- failure risk analysis --- decision making model --- risk assessment methodology --- experiments --- ultrasonic Doppler velocimetry (UDV) --- flowmeters --- computational fluid dynamics (CFD) --- pipe system efficiency --- pressure reducing valves --- leakage reduction --- water-energy nexus --- air–water interface --- filling --- flow --- pipelines --- transient --- water management --- reservoirs --- hydropower plants --- pumped storage power plants --- hydropeaking --- environmental flows --- smart water management --- smart water grids --- water drinking network --- water losses --- energy production --- pumped-storage --- micro-hydropower --- water networks --- dimensional analysis --- pumping system --- safety and control --- hydraulic transients and CFD analyses --- water systems efficiency --- new design solutions and eco-design

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The ongoing digitalization of the energy sector, which will make a large amount of data available, should not be viewed as a passive ICT application for energy technology or a threat to thermodynamics and fluid dynamics, in the light of the competition triggered by data mining and machine learning techniques. These new technologies must be posed on solid bases for the representation of energy systems and fluid machinery. Therefore, mathematical modelling is still relevant and its importance cannot be underestimated. The aim of this Special Issue was to collect contributions about mathematical modelling of energy systems and fluid machinery in order to build and consolidate the base of this knowledge.

centrifugal pump --- double hidden layer --- Levenberg–Marquardt algorithm --- performance prediction --- thermal energy storage --- stratification --- dynamic simulation --- heating --- double-channel sewage pump --- critical wall roughness --- numerical calculation --- external characteristics --- axial-flow pump --- impeller --- approximation model --- optimization design --- multi-disciplinary --- blade slot --- orthogonal test --- numerical simulation --- Francis turbine --- anti-cavity fins --- draft tube --- vortex rope --- low flow rates --- internal flow characteristics --- unsteady pressure --- energy recovery --- turboexpander --- throttling valves --- CFD --- modelling techniques --- Kaplan turbine --- draft tube optimization --- CFD analysis --- DOE --- response surface --- single-channel pump --- CFD-DEM coupling method --- particle features and behaviors --- solid-liquid two-phase flows --- computational fluid dynamics (CFD) --- artificial neural network (ANN) --- subcooled boiling flows --- uncertainty quantification (UQ) --- Monte Carlo dropout --- deep ensemble --- deep neural network (DNN) --- intake structures --- physical hydraulic model --- free surface flow --- free surface vortices --- vertical pump --- design considerations --- magnetocaloric effect --- coefficient of performance --- refrigeration --- capacity --- mathematical modelling --- energy systems