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This Special Issue reports research spanning from the analysis of indirect data, modeling, and laboratory and geological data confirming the intrinsic multidisciplinarity of gas hydrate studies. The study areas are (1) Arctic, (2) Brazil, (3) Chile, and (4) the Mediterranean region. The results furnished an important tessera of the knowledge about the relationship of a gas hydrate system with other complex natural phenomena such as climate change, slope stability and earthquakes, and human activities.

ocean acidification --- risk assessment --- modeling --- molecular composition --- ecosystem --- thermogenic gas --- Eastern Mediterranean --- temperature increase --- geohazards --- São Paulo Plateau --- geohazard --- hydrate dissociation --- climate change --- BSR --- thawing --- multidisciplinary --- clathrites --- earthquake --- modelling --- methane cycle --- permafrost --- global change --- methane --- biogenic gas --- salt migration --- subaqueous permafrost --- slope stability --- Chilean margin --- magnetic data --- mantellic source --- active margin --- Arctic shelf --- environmental impact --- Amazon fan --- methane emission --- seismic interpretation --- seep-carbonates --- Bouguer anomaly --- potential methods --- gravimetric data --- methane stability --- northern Apennines --- Santos Basin --- natural gas hydrate --- carbon dioxide --- blue growth --- gas seeps --- seepage --- Chile Triple Junction --- isotopic composition --- gas hydrates --- gas hydrate --- Miocene --- Levant Basin