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The central elements of this work are the design of an electricity tariff with variable capacity prices accepted by residential customers and the question how this tariff affects demand flexibility. Therefore, a corresponding tariff concept is developed. Based on an empirical study its acceptance and specific design is analyzed. The impact of different electricity tariffs on demand flexibility is analyzed with a developed bottom-up model for residential load profiles.

Variable energy and capacity prices --- Bottom-up Haushaltslastprofile --- Empirical study --- NachfrageflexibilitätResidential bottom-up load profiles --- Tariff acceptance and design --- Demand flexibility --- Variable Arbeits- und Leistungspreise --- Empirische Studie --- Tarifakzeptanz und -ausgestaltung

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Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.

n/a --- liver graft injury --- HFE --- neurokinin --- chemotherapy --- intestinal tumors --- therapeutic targets --- biliary tract carcinoma --- hepatocellular carcinoma --- clinical trial --- cell adhesion molecules --- colorectal cancer --- biomarkers --- phenotypic mosaics --- gastrointestinal oncology --- Asian Cancer Research Group (ACRG) --- biomarker --- psychosocial support --- precision therapy --- pancreatic carcinoma --- precision medicine --- Liver transplantation --- predictive biomarkers --- CD274 --- cholecystokinin --- The Cancer Genome Atlas (TCGA) --- gastrin --- pembrolizumab --- immunotherapy --- gastrin-releasing peptide --- stereotactic body radiation therapy --- immunohistochemistry --- gastric carcinoma --- liver transplant --- CAM invasion assay --- intragraft gene expression profiles --- molecular profiling --- targeted therapy --- neurotensin --- intestinal disorder --- ramucirumab --- next-generation sequencing --- colorectal carcinoma --- tumor progenitor --- circulating tumor cells --- gastrointestinal malignancies --- bombesin --- trastuzumab --- somatostatin --- zebrafish --- G protein–coupled receptors --- G protein-coupled receptors

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This book contains seven reviews and four research articles on the various modern approaches to the problem of quark confinement in quantum chromodynamics (QCD). These approaches include microscopic models of the Yang–Mills vacuum, which are based on the condensation of magnetic monopoles and center vortices, as well as the models of the confining quark-antiquark string. Possible applications of these models to the analysis of the novel superinsulating state, which emerges in such condensed-matter systems as Josephson junction arrays, are further discussed in one of the reviews. Two reviews from this collection discuss the approaches towards the analytic construction of effective confining theories, at the classical level and within the center-vortex model of the Yang–Mills vacuum. Other aspects of non-perturbative physics addressed by this collection include a possible connection between the localization of low-lying Dirac eigenmodes with the deconfinement and the chiral QCD phase transitions, as well as the role of topology in baryon-rich matter. Last but not least, a novel model of dark matter, based on ultralight axion particles, whose masses are arising due to distinct SU(2) Yang–Mills scales and the Planck mass, is suggested and developed in one of the contributed articles.

quantum chromodynamics --- confinement --- center vortex model --- vacuum structure --- cooling --- Lattice Gauge Theories --- Effective String Theories --- localization --- QCD --- lattice gauge theory --- finite temperature --- galaxy rotation curves --- low surface brightness --- dark matter --- dark energy --- ultralight axion particles --- cores --- halos --- mass-density --- profiles --- pure Yang–Mills theory --- monopoles --- topological interactions --- ensembles and effective fields --- topological solitons --- higher order theories --- gauge theory --- effective field theory --- magnetic flux symmetry --- chiral symmetry --- monopole --- lattice QCD --- spontaneous symmetry breaking --- Abelian projection --- magnetic catalysis --- magnetic disorder --- confinement models --- center vortices --- magnetic monopoles --- quark condensate --- topology --- lattice field theory --- dense matter --- phase transitions --- n/a --- pure Yang-Mills theory

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Soils --- Soil erosion --- Soil pollution --- Soil conservation --- Géomorphologie --- Geomorphology --- Pédogénèse --- soil genesis --- Propriété physicochimique du sol --- soil chemicophysical properties --- Profil du sol --- Soil profiles --- Biologie du sol --- Soil biology --- Écologie --- ecology --- Ressource en sol --- Soil resources --- Type de sol --- soil types --- Fertilité du sol --- soil fertility --- Utilisation des terres --- land use --- Classification des sols --- Soil classification --- Europe --- 912 <4> --- 912:631.4 --- 631.44 <4> --- 551 --- Cartografie. Kaarten. Plattegronden. Atlassen--Europa --- Maps. Atlasses: soils --- Classification of soils--Europa --- General geology. Meteorology. Climatology. Historical geology. Stratigraphy.Paleogeography. --- 631.44 --- Academic collection --- Classification of soils --- E-books --- Environmental Sciences and Forestry. Soil Science --- Land degradation and Land conservation --- 631.44 Classification of soils --- Land degradation and Land conservation. --- 551 General geology. Meteorology. Climatology. Historical geology. Stratigraphy.Paleogeography. --- 631.44 <4> Classification of soils--Europa --- Soils - Europe - Maps --- Soil erosion - Europe - Maps --- Soil pollution - Europe - Maps --- Soil conservation - Europe - Maps

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This book contains 12 articles covering biomedicine, nutrition, and the methodology of lipidomics . These works were first published by MDPI in a Special Issue of Metabolites. Phospholipids, sphingolipids, glyosylinositolphosphoceramides, cholesteryl esters, acyl-carnitines, and oxylipins are within the lipid classes accounted for studies regarding liver disease, Wilson disease, kidney disease, cardiovascular disease, adipogenesis, and the role lipids play in cancer and virus infection. High-throughput lipid extraction and guidelines for lipid annotation are addressed in several papers. This book is expected to provide a comprehensive view of the diverse areas where lipidomics looms largest.

chronic kidney disease --- leptin --- fatty acids --- adipose tissue --- adipocytes --- adipogenesis --- differential mobility spectrometry (DMS) --- lipidomics --- lipidyzer --- mass spectrometry --- metabolomics --- phenotyping --- Simpson-Golabi-Behmel syndrome (SGBS) --- COX --- CYP450 --- LOX --- oxylipins --- PUFAs --- UPLC-MS/MS --- copper --- Wilson’s disease --- lipidomic --- liquid chromatography --- tandem mass spectrometry --- molecular network --- dry eye disease --- hyperosmolarity --- cardiovascular disease --- heart failure --- myocardial infarction --- obesity --- diabetic cardiomyopathy --- dilated cardiomyopathy --- lipids --- odd chain lipids --- lipid profiling --- Folch --- protein precipitation --- sample preparation --- relative lipid composition (Mol%) --- atopic dermatitis --- SHARPIN-deficient mice --- flow-injection mass-spectrometry --- predictive elastic net --- immunotherapy --- cancer --- biomarkers --- metabolism --- cancer cell membranes --- fatty acid biosynthesis --- essential fatty acids --- desaturase enzymes --- fatty acid signaling --- fatty acid biomarker --- sapienic acid --- sebaleic acid --- molecular nutrition --- inflammation --- drug-induced liver injury --- biomarker --- plasma lipid profiles --- ssRNA+ virus --- membrane fusion --- lipid metabolism --- cholesterol --- sphingolipids --- phosphatidylinositol --- SARS-CoV --- glycolipidomics --- GIPC --- glycosyl inositol phospho ceramides --- Lipid Data Analyzer --- ultra-high pressure liquid chromatography --- high-resolution mass spectrometry --- LC-MS --- automated annotation