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For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.
?–? stacking --- encapsulation --- n/a --- oxindolimine–metal complexes --- cyclodextrin --- platinum iodido complexes --- distribution coefficient --- antiproliferative activity --- anticancer agents --- nanotubes --- ruthenium --- platinum --- Log kw --- nanoparticles --- drug discovery --- metal complex --- metallodrugs --- isatin-derived ligands --- anticancer drug --- upconverting nanoparticles --- pyridine benzimidazole --- dendrimers --- liposomes --- thiophene --- angiogenesis --- micelles --- HSA oxidation --- platinum(IV) --- imaging --- chromatographic lipophilicity parameter --- amidophosphine --- copper and iron chelators in cancer --- Log P --- biomacromolecules --- bones --- DNA cleavage --- stopped-flow spectroscopy --- silver --- phosphonates --- transmetalation --- metallomics --- MRI --- fluorescence quenching --- partition coefficient --- gold fingers --- anticancer --- HSA binding --- gold --- ?0 --- targeting --- metastasis --- DNA interaction --- antimigration --- cytotoxicity --- HPLC --- ruthenium complexes --- zinc finger proteins --- Gold(III) complexes --- aquaporins --- antiproliferative --- protein-DNA recognition --- photoactivation --- lipophilicity --- cancer --- 1-methylcytosine --- PET --- ?-? stacking --- oxindolimine-metal complexes
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The Close Linkage between Nutrition and Environment through Biodiversity and Sustainability: Local Foods, Traditional Recipes, and Sustainable Diets” is focused on the close correlation between the potential benefits and “functional role” of food and territory, and it includes papers on the characterization of local foods and traditional recipes as well as on the promotion of traditional dietary patterns and sustainable diets.
Klebsiella --- landraces --- conventional hams --- olive oil quality --- Food Composition Databases --- Cyprus --- traditional meat products --- sustainable development goals --- Schinziophyton rautanenii --- lupanine --- cheese --- Olea europaea L. --- environmental and socio-demographic factors --- agave sap --- environmental sustainability --- mountain --- chemometrics --- harvesting time --- metabolomics --- olive oil --- micronutrients --- typical/local foods --- Italian garlic --- carbohydrates --- innovative gastronomy --- fatty acid composition --- loyalty --- sustainability --- PCA --- processing system --- varieties --- traditional hams --- cultivar --- consumer culture theory --- post millennials --- dietary fibre --- macronutrients --- anticancer activity --- conventional sausages --- traditional food --- metallomics --- traditional foods --- antimicrobial --- altitude --- fructans --- germplasm --- local foods --- traditional recipes --- PIRG --- edible plants --- Pseudomonas --- pork --- bioactive components --- nutritional composition --- traditional dietary patterns --- climate resilience --- environmental conditions --- geographical origin --- saponins --- FTIR-ATR --- livelihood needs --- biodiversity --- sustainable diets --- fatty acids --- soluble sugars --- alkaloids --- Provolone del Monaco --- bioassay --- traditional sausages --- health --- tetraploid wheat --- antimicrobial activity --- agro-ecology biodiversity --- traditional Italian recipes --- sensorial evaluation --- food --- ecosystem goods and services --- Mediterranean --- plants adaptability --- Southern Africa --- actinomycetes --- fractions --- consumer preferences
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