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Pancreatic neoplasms include different pathological entities with variable biological behavior and different treatment modalities. Surgery and adjuvant therapy are the cornerstones of the therapeutic approach; however, even after radical resection, the majority of patients experience disease recurrence and the prognosis of pancreatic cancer remains dismal. A multimodal therapeutic approach, based on a combination of neoadjuvant therapy, chemotherapy, radiotherapy, immunotherapy and surgery, appears fundamental to improving the outcomes. This Special Issue of the Journal of Clinical Medicine, entitled “Recent Advances in Pancreatic Neoplasms”, focuses on possible new strategies to treat pancreatic neoplasms.
PIWI proteins --- PIWIL3 --- PIWIL4 --- pancreatic cancer --- EMT --- chemoresistance --- motility --- HNF4A --- survival --- pancreatic neuroendocrine neoplasm --- primary pancreatic carcinoid --- serotonin-secreting pancreatic tumour --- serotonin-producing pancreatic tumour --- neoadjuvant chemotherapy --- response --- carbohydrate antigen 19-9 --- fluorodeoxyglucose --- pancreatectomy --- positron emission tomography --- prognosis --- standardized uptake value --- Pancreatic ductal adenocarcinoma --- microRNAs --- pancreatic fistula --- pancreatic neoplasm --- renal cell carcinoma --- pancreatic neoplasms --- PET-CT scan --- pancreatic ductal adenocarcinoma --- pancreatic cancer prognosis --- completion total pancreatectomy --- pooled analysis --- recurrent pancreatic cancer --- repeated pancreatectomy --- pancreas --- neuropathy --- taxanes --- biomarker --- C-reactive protein to albumin ratio --- inflammation --- intraductal papillary mucinous neoplasm --- modified Glasgow prognostic score --- neutrophyl lymphocite ratio --- platelet-to-lymphocyte ratio --- robotic pancreatic surgery --- pancreato-gastrostomy --- low muscle mass --- sarcopenia --- pancreatic adenocarcinoma --- pancreatic surgery --- body composition --- n/a
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This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
Medicine --- Oncology --- thyroid carcinoma --- prophylactic central lymph node dissection --- lymph node metastases --- RET --- medullary thyroid carcinoma --- clinical management --- variants of uncertain significance --- differentiated thyroid cancer --- papillary thyroid cancer --- minimal extrathyroidal extension --- radioactive iodine therapy --- prognosis --- TNM --- histology --- multifocality --- lymph node metastasis --- vascular invasion --- autoimmune thyroid diseases --- radioiodine refractory --- Lenvatinib --- 18F-FDG-PET/CT --- cost-benefit analysis --- economics --- medical --- thyroid neoplasms --- radiomics --- ultrasound --- magnetic resonance imaging --- computer tomography --- prediction --- classification --- angiogenic microenvironment --- prognostic factors --- antiangiogenic therapy --- therapeutic target --- tumor microenvironment --- tumor behavior --- proliferation pathways --- cell cycle control pathways --- angiogenesis process --- thyroid cancer --- Gal-3 expression --- NIFTP --- EFVPTC --- lymphocytic thyroiditis (LT) --- immunohistochemical (IHC) analysis --- molecular imaging --- theranostics --- companion diagnostics --- immunoPET --- anaplastic thyroid cancer --- poorly thyroid cancer --- genetic landscape --- genetically guided therapy --- fluorodeoxyglucose F18 (18F-FDG) --- positron emission tomography (PET) --- magnetic resonance imaging (MRI) --- recurrence --- neoplasm metastasis --- thyroid surgery --- hypoparathyroidism --- fluorescence-guided surgery --- near-infrared autofluorescence --- PRKAR1A --- PKA --- Carney complex --- cAMP --- bone metastasis --- metastasectomy --- stereotactic radiosurgery --- ultrasound imaging --- thyroid nodule --- fine-needle aspiration --- papillary thyroid carcinoma --- lobectomy --- operative extent --- CONUT score --- tyrosine kinase inhibitors
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Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.
kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability
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There has been significant progress in the field of interventional cardiology, from the development of newer devices to newer applications of technology, resulting in improved cardiovascular outcomes. The goal of this Special Issue is to update practicing clinicians and provide a comprehensive collection of original articles, reviews, and editorials. To this end, we invited state-of-the-art reviews, including reviews of new technology and therapeutics, as well as original research in this area to be considered for inclusion in this issue. Examples include the history and evolution of interventional techniques, reviews of specific devices and technologies for coronary artery disease (i.e., stent technology, atherectomy devices, coronary physiology, intracoronary imaging, and robotics), structural heart diseases (i.e., ASD: atrial septal defect; LAAC: left atrial appendage closure; MC: MitraClip; PFO: patent foramen ovale; TAVI: transcatheter aortic valve implantation), advances in the management of challenging coronary anatomy, new biomarkers of cardiovascular disease (noncoding RNAs, etc.), and interventional techniques in the management of heart failure, peripheral arterial diseases, and pulmonary embolism. This Special Issue presents the most recent advances in the field of coronary and structural heart diseases as well as their implications for future patient care.
left atrial appendage --- WATCHMAN occlusive device --- 2D transesophageal echocardiography --- 3D transesophageal echocardiography --- computerized tomography --- atherosclerosis --- cholesterol --- FDG --- inflammation --- PET --- statins --- coronary artery bypass --- on-pump coronary artery bypass --- off-pump coronary artery bypass --- young patients --- severe aortic stenosis --- longitudinal axis strain --- late gadolinium enhancement --- cardiac magnetic resonance imaging --- optical coherence tomography --- percutaneous coronary interventions --- borderline lesions --- nonsignificant lesions --- left main --- bifurcations --- bilateral internal mammary artery --- coronary artery disease --- coronary artery bypass grafting --- da Vinci --- sternotomy --- outcome --- stent thrombosis --- bioresorbable scaffold --- drug eluting stents --- stent bioresorbable --- congenital heart disease --- cardiac surgery --- open heart --- progenitor cells --- regeneration --- stem cells --- subclinical coronary artery disease --- accelerated atherosclerosis --- HIV infection --- carotid intima-media thickness --- coronary calcium scoring --- coronary CT angiography --- magnetic resonance angiography --- fluorodeoxyglucose positron emission tomography --- mechanical circulatory support --- percutaneous coronary intervention --- cardiogenic shock --- acute myocardial infarction --- patient selection --- right heart catheterization --- pulmonary hypertension --- heart failure --- diagnosis --- prognostic evaluation --- clinical implications --- systemic disease --- cardiac computed tomography --- cardiac magnetic resonance --- feature tracking --- tagging --- myocardial deformation --- strain --- radial --- ulnar --- distal radial --- snuffbox --- aortic valvuloplasty --- dual antiplatelet therapy --- antiplatelet --- structural heart disease --- bioresorbable vascular scaffold --- drug-eluting stent --- angioplasty --- acute coronary syndrome --- chronic total occlusion --- target vessel failure --- re-occlusion --- surveillance coronary angiography --- meta-analysis --- ACURATE neo --- SAPIEN 3 --- transcatheter aortic valve replacement --- TAVR --- TAVI --- low risk --- STS --- aortic stenosis --- SAVR
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