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Book
Advances in Organic Corrosion Inhibitors and Protective Coatings
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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The interaction of metal with its environment that results in its chemical alteration is called metallic corrosion. According to the literature, corrosion is classified to two types: uniform and localized corrosion. Intervention in either in the alloy environment or in the alloy structure can provide the corrosion protection of metallic materials. Furthermore, the interference in the metal alloy environment can be conducted with the utilization of cathodic or anodic protection via the corresponding inhibitors. Therefore, the most common categorization is cathodic, anodic, and mixed-type inhibitors, taking into account which half-reaction they suppress during corrosion phenomena. The majority of the organic inhibitors are of mixed type and perform through chemisorption. In order to update the field of the corrosion protection of metal and metal alloys with the use of organic inhibitors, a Special Issue entitled "Advances in Organic Corrosion Inhibitors and Protective Coatings" is introduced. This book gathers and reviews a collection of ten contributions (nine articles and one review), from authors from Europe, Asia, and Africa, that were accepted for publication in this Special Issue of Applied Sciences.


Book
Mesoporous Materials for Drug Delivery and Theranostics
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.


Book
Nanoscale Self-Assembly: Nanopatterning and Metrology
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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The self-assembly process underlies a plethora of natural phenomena from the macro to the nano scale. Often, technological development has found great inspiration in the natural world, as evidenced by numerous fabrication techniques based on self-assembly (SA). One striking example is given by epitaxial growths, in which atoms represent the building blocks. In lithography, the use of self-assembling materials is considered an extremely promising patterning option to overcome the size scale limitations imposed by the conventional photolithographic methods. To this purpose, in the last two decades several supramolecular self-assembling materials have been investigated and successfully applied to create patterns at a nanometric scale. Although considerable progress has been made so far in the control of self-assembly processes applied to nanolithography, a number of unresolved problems related to the reproducibility and metrology of the self-assembled features are still open. Addressing these issues is mandatory in order to allow the widespread diffusion of SA materials for applications such as microelectronics, photonics, or biology. In this context, the aim of the present Special Issue is to gather original research papers and comprehensive reviews covering various aspects of the self-assembly processes applied to nanopatterning. Topics include the development of novel SA methods, the realization of nanometric structures and devices, and the improvement of their long-range order. Moreover, metrology issues related to the nanoscale characterization of self-assembled structures are addressed.


Book
Drug-Loaded Colloidal Systems in Nanomedicine II
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ISBN: 3036553592 3036553606 Year: 2022 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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This reprint highlights high-quality original research and review papers that include innovative colloidal drug delivery systems and cutting-edge characterization techniques that significantly contribute to the area of nanomedicine. The results presented are of high interest for specialists from a broad spectrum of fields, including biomedical, pharmaceutical, industrial, and biotechnological spheres.


Book
State-of-the-Art Liquid Crystals Research in UK
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ISBN: 3036561129 3036561110 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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The United Kingdom has a proud history of liquid crystal research. Its contributions span from the formulation of the theory of nematic elasticity as it is used today, uncovered via the Leslie–Erickson theory describing the viscosity of mesophases, to the discovery of the first room-temperature nematic and the related developments in the display industry, to name just several pioneering contributions. Today, liquid crystal science in the UK is more diverse and multidisciplinary than ever, ranging from the synthesis of increasingly complex mesogenic molecules, via the physical properties of self-organised systems and composites of both the thermotropic and the lyotropic type, to a wide variety of applications outside of the traditional display sector. The field covers aspects of chemistry, physics, material sciences, chemical engineering, mathematics, biology and device engineering in an overarching effort to advance the fundamental understanding of these soft-matter materials and to promote their technological exploitation in the UK and worldwide. To this end, a large group of individuals and research groups from universities and industry in the UK are working together on a Special Issue to advance the development of this field. The achievements of these scholars can be found in publications in top-class journals and presentations at all large international conferences, in the development of new products, and in events for public engagement.


Book
Active Organic and Organic-Inorganic Hybrid Coatings and Thin Films : Challenges, Developments, Perspectives
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Active (also called “smart”) coatings and thin films are defined as those that are capable of sensing their environment and appropriately responding to that external stimulus. This Special Issue “Active Organic and Organic-Inorganic Hybrid Coatings and Thin Films: Challenges, Developments, Perspectives” collected a series of papers that outline the current frontiers in the development of smart coatings and thin films for corrosion and other types of materials applications. The first four papers focus on novel discoveries on coatings with corrosion protection properties. These include environmentally-friendly polyurethane loaded with cerium nitrate corrosion inhibitor for mild steel protection, hot-pressed organic polymer coatings for the protection of pre-treated aluminum alloy surfaces exposed to NaCl aqueous solutions, functional epoxy coating with modified functional TiO2 for steel substrates protection, and hybrid composites against the thermo-oxidative corrosion of the metal parts of the internal combustion engines, turbines, and heaters. The next paper explores the potential of organic polymer/ceramic composite coatings to enhance the scratch resistance of typical floor laminates. The next three papers highlight other types of smart coatings and thin films, including low-temperature curable hybrid dielectric materials for field-effect transistors, bilayer antireflective coatings for optoelectronic devices, and organic polymers as the thin-film component for enthalpy exchanger systems in air conditioning applications. The final two papers focus on important research specific to coatings that serve as protection and preservation cultural heritage materials.


Book
Block Copolymers with Crystallizable Blocks: Synthesis, Self-Assembly and Applications
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Block copolymers with crystallizable blocks have moved into the focus of current research, owing to their unique self-assembly behaviour and properties. New synthetic concepts give, for example, even access to tetrablock copolymers with four crystalline blocks, bio-based thermoplastic elastomers (e.g., based on ABA triblock copolymers with poly(L-lactide) (PLLA) hard segments), and allow new, exciting insights into the interplay of microphase separation and crystallization in controlling self-assembly in bulk (confined vs. break-out crystalliza­tion).Concerning self-assembly in solution, crystallization-driven self-assembly (CDSA) paved the way to a myriad of crystalline-core micellar structures and hierarchical super­structures that were not accessible before via self-assembly of fully amorphous block copolymers. This allows for the production of cylindrical micelles with defined lengths, length distribution, and corona chemistries (block type or patchy corona), as well as branched micelles and fascinating micellar superstructures (e.g., 2D lenticular platelets, scarf-shaped micelles, multidimensional micellar assemblies, and cross and “windmill”-like supermicelles).This Special Issue brings together new developments in the synthesis and self-assembly of block copolymers with crystallizable blocks and also addresses emerging applications for these exciting materials. It includes two reviews on CDSA and eight contributions spanning from membranes for gas separation to self-assembly in bulk and solution.


Book
Drug Delivery Systems Based on Polysaccharides
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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We live in a constantly changing society, in which life expectancy has continuously increased, and, therefore, important health issues need to be solved. The development of nanotechnology with applications in the medical field—nanomedicine—has been proven to have strong therapeutic potential, especially by combining drugs with natural polymers, polysaccharides being most commonly used in the development of sustained and controlled release systems of biologically active principles. Polymeric nanoparticles loaded with drugs can actively target various diseases, being able to penetrate cells more effectively or succeed in overcoming some physiological barriers such as the blood–brain barrier. Drug-loaded hydrogels are used to treat dermal and dental conditions, and can act as scaffolds for the development of cell cultures with applications in tissue engineering. The recent literature abounds with articles discussing aspects of obtaining new polymer drug systems and their use in various biomedical applications. The editors of this Special Issue of the journal Molecules, entitled Drug Delivery Systems Based on Polysaccharides, are researchers with decades of experience in this field, and they consider justified and useful these several articles which report recent results of drug delivery systems based on polysaccharides and derivatives, respectively, and their biomedical applications. The authors of the articles are experts in the field, and the editors express their gratitude for the kindness and promptness with which they responded to the call to contribute the recently obtained results of their research to this specific edition of the journal Molecules.


Book
Nanomedicine Formulations Based on PLGA Nanoparticles for Diagnosis, Monitoring and Treatment of Disease: From Bench to Bedside
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Nanomedicine is among the most promising emerging fields that can provide innovative and radical solutions to unmet needs in pharmaceutical formulation development. Encapsulation of active pharmaceutical ingredients within nano-size carriers offers several benefits, namely, protection of the therapeutic agents from degradation, their increased solubility and bioavailability, improved pharmacokinetics, reduced toxicity, enhanced therapeutic efficacy, decreased drug immunogenicity, targeted delivery, and simultaneous imaging and treatment options with a single system.Poly(lactide-co-glycolide) (PLGA) is one of the most commonly used polymers in nanomedicine formulations due to its excellent biocompatibility, tunable degradation characteristics, and high versatility. Furthermore, PLGA is approved by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) for use in pharmaceutical products. Nanomedicines based on PLGA nanoparticles can offer tremendous opportunities in the diagnosis, monitoring, and treatment of various diseases.This Special Issue aims to focus on the bench-to-bedside development of PLGA nanoparticles including (but not limited to) design, development, physicochemical characterization, scale-up production, efficacy and safety assessment, and biodistribution studies of these nanomedicine formulations.

Keywords

poly(lactic-co-glycolic acid) (PLGA) --- blood–brain barrier (BBB) --- current Good Manufacturing Practice (cGMP) --- Food and Drug Administration (FDA) --- nanotechnology --- PLGA nanoparticles --- neurodegenerative diseases --- drug delivery --- central nervous system --- neuroprotective drugs --- fluorescent labeling --- DiI --- coumarin 6 --- rhodamine 123 --- Cy5.5 --- quantum yield --- brightness --- stability of fluorescent label --- confocal microscopy --- intracellular internalization --- in vivo neuroimaging --- double-emulsion method --- dry powder inhalation --- antigen release --- porous PLGA particles --- microfluidics --- methotrexate --- chitosan --- PLA/PLGA --- sustained release --- micro-implant --- animal model --- minimally invasive --- drug delivery system --- nanoparticles --- poly (lactic-co-glycolic acid) (PLGA) --- microfluidic --- pharmacokinetics (PK) and biodistribution --- atorvastatin calcium --- poly(lactide-co-glycolide) --- polymeric nanoparticles --- carrageenan induced inflammation --- anti-inflammatory --- radiolabeled nanoparticles --- nuclear medicine --- photothermal therapy --- phthalocyanine --- SKOVip-kat --- Katushka --- TurboFP635 --- JO-4 --- PLGA --- orthotopic tumors --- 3D culture --- spheroids --- poly(lactic-co-glycolic acid) --- nanomedicine --- scale-up manufacturing --- clinical translation --- inline sonication --- tangential flow filtration --- lyophilization --- downstream processing --- H. pylori --- design of experiments --- poly(lactic-co-glycolic) acid --- size --- cancer --- chemoimmunotherapy --- immunogenic cell death --- immune checkpoint blockade --- PNA5 glycopeptide --- mas receptor --- angiotensin --- PLGA diblock copolymer --- ester and acid-end capped --- double emulsion solvent evaporation --- biocompatible --- biodegradable --- cardiovascular --- nanoparticle --- solid-state characterization --- in vitro --- drug release kinetics modeling --- PEGylation --- amine --- emulsion --- polyvinyl alcohol (PVA) --- Pluronic triblock copolymer --- trehalose --- sucrose --- Indomethacin --- solvents --- stabilizers --- morphology --- particle-size --- encapsulation --- drug release --- cytotoxicity


Book
Advances in Thermoresponsive Polymers
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Thermoresponsive polymers, materials able to undergo sharp and often reversible phase separations in response to temperature stimuli, are introducing new paradigms in different fields, including medicine, advanced separations and oil and gas. In "Advances in Thermoresponsive Polymers", a clear picture of the frontiers reached in the understanding of the mechanistic behavior associated with temperature-induced phase separation, the influence of the polymer structure in regulating the macroscopic behavior of these materials and the latest applications for which thermoresponsive polymers show great potential is provided.

Keywords

poly(N,N-diethylacrylamide) --- glycidyl methacrylate --- thermoresponsive copolymer --- α-chymotrypsin --- polymer-enzyme conjugate nanoparticle --- polymeric nanoparticles --- emulsion polymerization --- RAFT --- thermo-responsive polymers --- smart materials --- LCST --- phase diagram --- phase separation --- thermoresponsive star-shaped polymers --- poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines --- aqueous solutions --- light scattering --- turbidimetry --- microcalorimetry --- aggregation --- dual-stimuli-responsive materials --- thin films --- out-of-equilibrium --- thermoresponsive --- oligo(ethylene glycol) --- OEGylated --- poly(amino acid) --- ring-opening polymerization --- post-polymerization modification --- Ugi reaction --- synthesis --- star-shaped macromolecules --- calix[n]arene --- block and gradient copolymers of poly-2-alkyl-2-oxazolines --- conformation --- thermoresponsibility --- self-organization --- poly-N-vinylcaprolactam --- thermoresponsive polymers --- polymer-protein conjugates --- controlled release --- temperature-sensitive polymers --- hydrogels --- stereocomplexation --- polylactic acid --- temperature/reduction --- self-recombination --- thermosensitive polymers --- enzyme complexation --- reversible inactivation --- UCST polymers --- stimuli-responsive polymers --- electronic paramagnetic resonance --- spin probe --- nitroxides --- coil to globule --- poly(L-lysine) --- N-isopropylacrylamide --- aza-Michael addition reaction --- thermo-responsive --- pH-responsive --- biodegradable polymer

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