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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
computational model --- animal --- decision making --- motor control
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
quantitative physiology --- multiscale model --- computational model --- physiome --- systems biology --- complexity
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This book includes a selection of papers showing the potential of the dynamic modelling approach to treat problems related to the musculoskeletal system. The state-of-the-art is presented in a review article and in a perspective paper, and several examples of application in different clinical problems are provided.
musculoskeletal model --- pregnancy --- motion analysis --- muscle load evaluation --- low back pain --- deglutition --- muscle activity --- simulation --- swallowing biomechanics --- musculoskeletal modelling --- musculoskeletal simulations --- clinical research --- rehabilitation --- biomechanics --- rectus femoris --- foot kinematics --- knee kinematics --- normal gait --- gait cycle --- forward modeling --- musculoskeletal modeling --- neuromusculoskeletal model --- computational model --- model personalization --- treatment optimization --- treatment design --- predictive simulation --- human movement --- total hip replacement --- hip dysplasia --- hip abductor muscles --- gait analysis --- knee joint ligaments --- walking --- dynamic simulation --- knee joint biomechanics --- polyethylene thickness --- total knee arthroplasty --- ligament forces --- compressive forces --- patellar kinematics --- n/a
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The free energy principle is a mathematical theory of the behaviour of self-organising systems that originally gained prominence as a unified model of the brain. Since then, the theory has been applied to a plethora of biological phenomena, extending from single-celled and multicellular organisms through to niche construction and human culture, and even the emergence of life itself. The free energy principle tells us that perception and action operate synergistically to minimize an organism’s exposure to surprising biological states, which are more likely to lead to decay. A key corollary of this hypothesis is active inference—the idea that all behavior involves the selective sampling of sensory data so that we experience what we expect to (in order to avoid surprises). Simply put, we act upon the world to fulfill our expectations. It is now widely recognized that the implications of the free energy principle for our understanding of the human mind and behavior are far-reaching and profound. To date, however, its capacity to extend beyond our brain—to more generally explain living and other complex adaptive systems—has only just begun to be explored. The aim of this collection is to showcase the breadth of the free energy principle as a unified theory of complex adaptive systems—conscious, social, living, or not.
message passing --- metabolism --- Bayesian --- stochastic --- non-equilibrium --- master equations --- cancer niches --- free energy --- Kikuchi approximations --- apoptosis --- metastasis --- cluster variation method --- Free Energy Principle --- active inference --- Bayesian brain --- generative models --- cybernetics --- embodiment --- enactivism --- cognitivism --- representations --- consciousness --- free will --- mental causation --- cognitive-affective development --- emotions --- feelings --- readiness potentials --- intentionality --- agency --- intelligence --- collective intelligence --- free energy principle --- agent-based model --- complex adaptive systems --- multiscale systems --- computational model --- uncertainty --- POMDP --- emotion --- affect control theory --- sociology --- permutation entropy --- disorder --- stress --- allostatic (hub) overload --- cascading failure --- disease --- hierarchical control systems --- critical slowing down --- model-based control --- adaptive robots --- generative model --- Bayesian inference --- filtering --- neurotechnology --- n/a
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Modern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics data. A primary goal of this Special Issue, entitled “Methods in Computational Biology”, is the communication of computational biology methods, which can extract biological design principles from complex data sets, described in enough detail to permit the reproduction of the results. This issue integrates interdisciplinary researchers such as biologists, computer scientists, engineers, and mathematicians to advance biological systems analysis. The Special Issue contains the following sections:•Reviews of Computational Methods•Computational Analysis of Biological Dynamics: From Molecular to Cellular to Tissue/Consortia Levels•The Interface of Biotic and Abiotic Processes•Processing of Large Data Sets for Enhanced Analysis•Parameter Optimization and Measurement
n/a --- inosine --- immune checkpoint inhibitor --- geometric singular perturbation theory --- simulation --- BioModels Database --- ADAR --- calcium current --- bifurcation analysis --- bacterial biofilms --- nonlinear dynamics --- explanatory model --- turning point bifurcation --- oscillator --- workflow --- bioreactor integrated modeling --- modeling methods --- elementary flux modes visualization --- multiscale systems biology --- evolutionary algorithm --- metabolic model --- differential evolution --- reduced-order model --- computational model --- gut microbiota dysbiosis --- canard-induced EADs --- computational biology --- metabolic modelling --- methods --- SREBP-2 --- mechanistic model --- systems modeling --- biological networks --- macromolecular composition --- provenance --- flux balance analysis --- immunotherapy --- compartmental modeling --- immuno-oncology --- metabolic network visualization --- mechanism --- bistable switch --- Clostridium difficile infection --- bioreactor operation optimization --- microRNA targeting --- CFD simulation --- biomass reaction --- RNA editing --- ordinary differential equation --- metabolic modeling --- mass-action networks --- hybrid model --- multiple time scales --- quantitative systems pharmacology (QSP) --- mathematical modeling --- microRNA --- cancer --- parameter optimization --- Hopf bifurcation --- breast
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Modern engineering design processes are driven by the extensive use of numerical simulations; naval architecture and ocean engineering are no exception. Computational power has been improved over the last few decades; therefore, the integration of different tools such as CAD, FEM, CFD, and CAM has enabled complex modeling and manufacturing problems to be solved in a more feasible way. Classical naval design methodology can take advantage of this integration, giving rise to more robust designs in terms of shape, structural and hydrodynamic performances, and the manufacturing process.This Special Issue invites researchers and engineers from both academia and the industry to publish the latest progress in design and manufacturing techniques in marine engineering and to debate the current issues and future perspectives in this research area. Suitable topics for this issue include, but are not limited to, the following:CAD-based approaches for designing the hull and appendages of sailing and engine-powered boats and comparisons with traditional techniques;Finite element method applications to predict the structural performance of the whole boat or of a portion of it, with particular attention to the modeling of the material used;Embedded measurement systems for structural health monitoring;Determination of hydrodynamic efficiency using experimental, numerical, or semi-empiric methods for displacement and planning hulls;Topology optimization techniques to overcome traditional scantling criteria based on international standards;Applications of additive manufacturing to derive innovative shapes for internal reinforcements or sandwich hull structures.
wave compensation platform --- 3-SPR parallel platform --- 3-RPS parallel platform --- structure optimization --- workspace analysis --- level 4 sea state --- cryogenic tank --- boil-off gas (BOG) --- boil-off rate (BOR) --- finite element analysis (FEA) --- liquid nitrogen --- near-bottom zooplankton --- multi-net --- visible sampling --- fidelity --- deep sea --- sailing yacht design --- rational Bézier curves --- VBA --- excel --- CAD --- VPP --- computational fluid dynamics --- hull design --- air cavity ships --- hull ventilation --- stepped planing hull --- Cartesian adaptive grids --- immersed boundaries --- LES simulation --- velocity prediction program --- numerical optimization --- High-Fidelity analysis --- geometric parameterization --- multihull design --- finite element method --- FSI --- sail design --- gennaker --- sail loads --- biomimetic design --- lightweight structure --- computer fluid dynamics --- design for additive manufacturing --- autonomous underwater vehicle (AUV) --- collision avoidance planning --- deep reinforcement learning (DRL) --- double-DQN (D-DQN) --- computational model --- oscillating water column --- wave energy converter --- turbulent flows --- Savonius turbine --- n/a --- rational Bézier curves
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This book covers a wide range of topics in the orthopaedic fields and can be used as a textbook for the final undergraduate engineering course or as a topic on tribology at the postgraduate level. This book can serve as a useful reference for academics, tribology, and materials researchers; mechanical, materials, and physics engineers; biomedical scientists and professionals in tribology; and related industries. The scientific interest in this book will be evident for many important centres of research, including laboratories and universities throughout the world.
vitamin-E stabilized PE --- cross-linked PE --- standard PE --- hip simulator --- FTIR analysis --- Ti-28Nb-35.4 alloy --- powder metallurgy --- ball milling --- mechanical properties --- biocompatibility --- total hip arthroplasty --- musculoskeletal multibody model --- dynamic loading --- finite element analysis --- radial clearance --- dry and wet friction --- digital image correlation --- homogeneous strain --- small deformation level --- accuracy --- precision --- calcium phosphate cements --- polarization --- CoCr alloy --- wear particles --- hyaluronic acid --- macrophages biocompatibility --- UHMWPE --- tribology --- h-index --- bibliometric indicators --- biomaterials --- quality of research --- citations --- ceramic --- friction --- hip --- implants --- polyethylene --- prosthesis --- simulator --- wear --- mandible condylar fractures --- surgical treatment --- titanium --- PLLA --- Selective Laser Melting --- Direct Metal Laser Sintering --- porosity --- titanium alloys --- yield strength --- ultimate tensile strength --- X-Ray Diffraction --- n/a --- computational model --- biomechanics --- unicompartmental knee replacement --- CFR-PEEK --- varus and valgus alignments --- bioceramics --- additive manufacturing --- scaffolds --- bone tissue engineering
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Modern information communication technology eradicates barriers of geographic distances, making the world globally interdependent, but this spatial globalization has not eliminated cultural fragmentation. The Two Cultures of C.P. Snow (that of science–technology and that of humanities) are drifting apart even faster than before, and they themselves crumble into increasingly specialized domains. Disintegrated knowledge has become subservient to the competition in technological and economic race leading in the direction chosen not by the reason, intellect, and shared value-based judgement, but rather by the whims of autocratic leaders or fashion controlled by marketers for the purposes of political or economic dominance. If we want to restore the authority of our best available knowledge and democratic values in guiding humanity, first we have to reintegrate scattered domains of human knowledge and values and offer an evolving and diverse vision of common reality unified by sound methodology. This collection of articles responds to the call from the journal Philosophies to build a new, networked world of knowledge with domain specialists from different disciplines interacting and connecting with other knowledge-and-values-producing and knowledge-and-values-consuming communities in an inclusive, extended, contemporary natural–philosophic manner. In this process of synthesis, scientific and philosophical investigations enrich each other—with sciences informing philosophies about the best current knowledge of the world, both natural and human-made—while philosophies scrutinize the ontological, epistemological, and methodological foundations of sciences, providing scientists with questions and conceptual analyses. This is all directed at extending and deepening our existing comprehension of the world, including ourselves, both as humans and as societies, and humankind.
pessimistic induction --- n/a --- qualitative ontology --- dissipative structures --- physicalism --- agent-based reasoning --- thermodynamics --- the logic of nature --- reverse mathematics --- theoretical unity --- state-space approach --- common good --- naturalization of logic --- monad --- metaphysics --- reflexive psychology --- knowledge --- neurodynamics --- consciousness --- third-way reasoning --- induction and discovery of laws --- mind-matter relations --- exoplanet --- Second Law of thermodynamics --- unitarity --- philosophical foundations --- in the name of nature --- big crunch --- epistemology --- eco-cognitive model --- active imagination --- aesthetics in science --- science --- second-person description --- subsumptive hierarchy --- 1st-person and 3rd-person perspectives --- discursive space --- space flight --- complexity --- cybernetics --- cosmology --- matter --- realism --- eco-cognitive openness --- hylomorphism --- measurement --- fallacies --- induction --- vacuum --- physics --- mental representation --- embodiment --- problem of induction --- contradiction --- internalism --- Jungian psychology --- synthesis --- exceptional experiences --- mind --- relational biology --- symmetry breaking --- emergence --- phenomenological psychology --- Aristotle’s four causes --- humanistic management --- real computing --- A.N. Whitehead --- final cause --- naturalism --- induction and concept formation --- temporality --- dispositions --- dark energy --- heterogeneity --- Naturphilosophie --- computation --- causality --- memory evolutive system --- natural philosophy --- quantum computing --- philosophy of information --- self --- information --- analytical psychology --- logic --- indeterminacy --- scientific method --- dialectics --- computability --- language --- ethics --- perception --- philosophy of nature --- agonism --- errors of reasoning --- everyday lifeworld --- emptiness --- awareness --- unity of knowledge --- digitization --- fitness --- depth psychology --- info-computational model --- creativity --- ontology --- philosophy as a way of life --- development --- void --- big freeze --- signal transduction --- abduction --- retrocausality --- dual-aspect monism --- quantum information --- theoretical biology --- acategoriality --- epistemic norms --- evolutionary psychology --- apophasis --- differentiation --- memory --- centripetality --- mathematics --- Leibniz --- Ivor Leclerc --- spatial representation --- subjective experience --- intentionality --- evidence and justification --- internal quantum state --- scientific progress --- holographic encoding --- information-theory --- qualia --- anticipation --- naturalization --- F.W.J. Schelling --- L. Smolin --- R.M. Unger --- Aristotle --- dual aspects --- process --- theory of everything --- philosophy of science --- cognition --- compositional hierarchy --- autocatalysis --- discourse --- emergentist reductionism --- form --- regulation --- contingency --- endogenous selection --- category theory --- Science --- Philosophy of nature. --- Philosophy. --- Nature --- Nature, Philosophy of --- Natural theology --- Normal science --- Philosophy of science --- Philosophy --- Aristotle's four causes
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