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This book is intended to act as an up-to-date reference point and knowledge developer for all readers interested in the area of gastroenterology and in particular, Ulcerative Colitis. All authors of the chapters are experts in their fields of publication, and deserve individual credit and praise for their contributions to the world of Ulcerative Colitis. We hope that you will find this publication informative, stimulating, and a reference point for the area of Ulcerative colitis as we move forward in our understanding of the field of medicine.

Ulcerative colitis. --- Colitis --- Inflammatory bowel diseases --- Hepatology

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This book is intended to act as an up to date reference point and knowledge developer for all readers interested in the area of gastroenterology and in particular Ulcerative Colitis. All of the chapter authors are experts in their fields of publication and deserve individual credit and praise for their contributions to the world of Ulcerative Colitis. We hope that you will find this publication informative, stimulating and a reference point for the area of Ulcerative colitis as we move forward in our understanding of the field of medicine.

Ulcerative colitis --- Treatment. --- Colitis --- Inflammatory bowel diseases --- Hepatology

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Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.

chronic intestinal pseudo-obstruction --- parenteral nutrition --- pediatrics --- myopathy --- neuropathy --- IBS --- microbiota --- visceral hypersensitivity --- colorectal motility --- inflammatory bowel disease --- Crohn’s disease --- ulcerative colitis --- anti-TNF --- ustekinumab --- vedolizumab --- postoperative complications --- surgery --- preoperative therapy --- biologic therapy --- bio-naïve --- IBD --- pro-inflammatory cytokines --- lymphocyte migration --- treatment --- inflammatory bowel diseases --- biologic treatment --- combination --- n/a --- Crohn's disease --- bio-naïve

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Ischemic heart disease is a cardiovascular condition with very high prevalence worldwide and a major source of morbidity and mortality, especially in the geriatric population. The management of coronary artery disease is one that requires high-level expertise. The presence of comorbidities, usually multiple at advanced ages, makes the diagnosis and therapy very challenging. In this setting, the effort of a multidisciplinary team is urgently needed to achieve integrated management of these cases, being the only one capable of leading to the best results for the patient.The purpose of this reprint is to bring together the experience of specialists in treating ischemic heart disease in the presence of major related conditions that require particular modulations of diagnostic and therapeutic interventions. The chapters address difficult areas of interference between ischemic heart disease and frailty, cancer, liver diseases, inflammatory bowel disease and the new SARS-CoV-2 infection. Special consideration is granted to cardiac remodeling and progression to heart failure. Niche topics such as acute coronary syndromes triggered by carbon monoxide poisoning are present as well. The book also contains a particularly interesting chapter dedicated to the genetic substrate of ischemic heart disease, which once again emphasizes the need for a multidisciplinary team approach to this disease.We consider the reprint an excellent source of information for medical practitioners who have to solve complex cases of ischemic heart disease.

Medicine --- Cardiovascular medicine --- coronary artery disease --- ischemic heart disease --- atherosclerosis --- genetic risk factors --- heritability --- polymorphism --- GWAS --- PRS --- COVID-19 --- myocardial ischemia --- electrocardiography --- accelerated atherosclerosis --- coronary spasm --- coronary thrombosis --- endothelial dysfunction --- cancer --- prevention --- radiotherapy --- chemotherapy --- liver cirrhosis --- prevalence --- liver transplantation --- treatment --- myocardial injury --- cytokines --- biomarkers --- heart failure --- left ventricular remodeling --- myocardial infarction --- wall stress --- inflammation --- neurohormonal activation --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- cardiovascular risk --- frailty --- chronic coronary syndrome --- elderly --- acute coronary syndrome --- carbon monoxide poisoning --- severity of poisoning --- cardiotoxicity --- troponin --- cardiac dysfunction --- non-alcoholic fatty liver disease --- liver-heart axis --- n/a --- Crohn's disease

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Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.

n/a --- transient receptor potential channels --- photochromic ligands --- elementary immunology --- Purkinje cell --- EPSC --- substance P --- chemicals --- organ toxicity --- lymphocytes --- HSP70 --- physiology --- bioavailable --- inflammatory bowel disease --- platelets --- pollutants --- yeast --- regulatory T cells --- kinase --- Saccharomyces cerevisiae --- manganese --- cerebellum --- TRP channel --- NHERF --- inflammation --- nanoHPLC-ESI MS/MS --- TRPM7 --- chemical probes --- TRPM8 --- dorsal column nuclei --- TRPV2 --- TRPV3 --- calcitonin gene-related peptide --- TRPV1 --- ion channels --- transient receptor potential --- 2D gel electrophoresis --- MALDI-TOF MS(/MS) --- TRPV4 --- overproduction --- sulfur mustard --- oxidative stress --- graft versus host disease --- menthol --- topical --- chemosensor --- AP18 --- calcium signalling --- mucosal epithelium --- cuneate nucleus --- production platform --- TRPC channels --- ulcerative colitis --- channel structure --- xerostomia --- neutrophils --- cardiovascular system --- TRPC5 --- TRPC6 --- TRPC3 --- TRPC4 --- calcium signaling --- protein purification --- adipose tissue --- transient receptor potential (TRP) channels --- sodium --- TH17 --- diacylglycerol --- hypersensitivity --- TRPY1 --- GABAB --- HEK293 --- thrombosis --- ion channel --- TRPC --- pathophysiology --- SMAD --- toxicology --- endothelium --- calcium --- proteomics --- TRPA1 --- salivary glands --- TRP channels --- lipid mediators --- sensors --- radiation --- TRPM4 channel --- human medulla oblongata --- mGluR1 --- small molecules --- TRPC3 pharmacology