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Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection.Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large.This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis.

Communicable Diseases --- Public Health --- Health & Biological Sciences --- Schistosomiasis --- Schistosoma mansoni --- S japonicum --- neglected tropical diseases --- infection induced cancer --- Anthelmintic drugs --- S haematobium --- Blood fluke --- Vaccines --- Helminthiasis

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Tropical emerging diseases pose a significant risk for the circulation of old and new pathogens in areas previously unknown, also implying the possibility of new morbidities and mortalities and new consequences for naïve populations. Globalization, migration and travel are key factors for tropical diseases, and represent the need for integration of tropical medicine, travel medicine and epidemiology in the understanding of such complex situations. Neglected tropical diseases such as leprosy or Chagas disease, arboviral diseases, HIV, Ebola, and arenaviral infections are just a few examples. This book tries to update significant epidemiological and clinical research in many aspects with a multinational perspective.

Emerging infectious diseases. --- Tropical medicine. --- Diseases, Tropical --- Hygiene, Tropical --- Medicine --- Public health, Tropical --- Sanitation, Tropical --- Tropical diseases --- Medical climatology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Public Health --- Global Health --- Health Sciences

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Organizada pelo historiador Jaime Benchimol e pela bióloga e historiadora da ciência Magali Romero Sá, é uma homenagem ao pesquisador e à sua trajetória. Adolpho Lutz foi o precursor das modernas campanhas sanitárias e dos estudos epidemiológicos envolvendo, sobretudo, o cólera, a febre tifóide, a peste bubônica e a febre amarela. Os quatro primeiros volumes da obra - que consistirá, quando completa, numa coleção de 21 livros acondicionados em cinco caixas - trazem: Primeiros Trabalhos: Alemanha, Suíça e Brasil (1878-1885); Hanseníase; Dermatologia e Micologia e ainda um suplemento contendo sumário, glossário e índices. Neles, os organizadores recuperaram o arquivo pessoal do cientista e de sua filha, a bióloga Bertha Lutz.

Entomology. --- Clinical medicine --- Tropical medicine --- Scientific expeditions --- History. --- History --- Lutz, Adolpho, --- Entomologia --- Expeditions, Scientific --- Scientific voyages --- Travels --- Voyages, Scientific --- Voyages and travels --- Diseases, Tropical --- Hygiene, Tropical --- Medicine --- Public health, Tropical --- Sanitation, Tropical --- Tropical diseases --- Medical climatology --- Medicine, Clinical --- Insects --- Zoology --- Lutz, Adolph, --- Entomology

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This Special Issue explores the range of clinical manifestations and epidemiology of both skin NTDs and common skin disease in endemic regions, the use of common diagnostic and management pathways, the different technologies that play a role in diagnosis and training, the role of patient involvement at a community level, as well as the assessment of the results of different initiatives in the field.

n/a --- topical corticosteroids --- mental health --- digital handheld microscope --- skin infections --- sporotrichosis Community dermatology --- mHealth --- animal reservoir --- iatrogenic --- case management --- Wet Dermatoscopy (w-DS) --- Mycobacterium ulcerans --- transmission --- neglected tropical diseases --- review --- Enhanced Dermatoscopy (e-DS) --- outbreak --- long range diagnosis --- teledermatology --- Treponema pallidum --- leprosy --- onchocerciasis --- mass drug administration --- point of care test --- scabies --- Africa --- podoconiosis --- Mite-Gallery Unit (MGU) --- diagnosis --- Amerindian communities --- eumycetoma --- community engagement --- clinical presentation --- integration --- onchocercal skin disease --- mycetoma --- PCR --- mobile phone application --- stigma --- resource-poor setting --- slit skin smears --- morbidity management --- training --- tele-expertise --- ivermectin --- eHealth --- NTDs --- Dry Dermatoscopy (d-DS) --- Amazon lowland --- actinomycetoma --- patient involvement --- tropical skin diseases --- surveillance --- yaws --- skin diseases --- skin NTDs --- lymphedema --- Cushing syndrome --- onchodermatitis --- skin disease --- primary health care --- technology --- skin biopsy --- impetigo --- early diagnosis --- dermatology --- telepathology --- drought --- subcutaneous mycosis --- disease mapping --- emergency state --- Entodermoscopy (EDS) --- leprosy diagnosis

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Scale up and implementation of new point-of-care (POC) diagnostics is a global health priority to enable the adoption of new evidence-based POC diagnostics and to replicate and extend the reach of POC diagnostics. Global private and public sector agencies have significantly increased their investment in the development of POC diagnostics to meet the unmet needs of patients in resource-limited settings, particularly disease burdened settings with limited access to laboratory infrastructure. However, previous research has demonstrated that the availability of health technologies in these settings does not always guarantee patient-centered outcomes. The applicability, effectiveness and sustainability of diagnostic technologies is affected by the involvement of all stakeholders during planning and implementation, which must be relevant to each specific context and sensitive to local culture. Factors such as infrastructure, resources, values and characteristics of participants can influence the implementation, scalability and sustainability of health interventions such as POC diagnostics. This book, “Implementation and Scale up of Point of Care (POC) Diagnostics in Resource-Limited Settings”, presents literature reviews and primary research studies focusing on the implementation and scale up of POC diagnostics in resource-limited settings.

point-of-care-ultrasound --- ultrasound --- implementation --- point of care ultrasound --- augmented reality --- telemedicine --- spatial accessibility --- blood group --- rhesus type --- point-of-care testing --- maternal healthcare --- Upper East Region --- Ghana --- point-of-care ultrasound --- medical education --- syphilis --- maternal mortality --- interrupted time series --- segmented regression analysis --- point-of-care CD4+ t testing --- qualitative survey --- acceptability --- patients --- healthcare providers --- primary healthcare clinics --- HIV self-testing --- scale-up --- key stakeholder --- quality HIV point-of-care-diagnostics --- nominal group technique --- stakeholder engagement --- self-testing --- novel coronavirus disease-19 --- blockchain --- artificial intelligence --- geographical access --- glucose-6-phosphate dioxygenase deficiency --- antenatal care --- upper east region --- schistosomiasis --- barriers to diagnostics --- access to healthcare --- end-user perspectives --- neglected tropical diseases --- Nigeria --- case management --- electronic health information system --- diagnosis --- treatment --- point-of-care --- low and middle income countries --- point-of-care diagnostics --- healthcare services --- COVID-19 era