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This work analyses the emergent European border surveillance regime as part of the European border regime/migratory regime and the power structures this technologogical regime is embedded into, is reproducing and creating. The history, politics, policies and technological characteristics of the border surveillance regime of the EU are analysed through a theoretical framework based in political science, political sociology and surveillance studies.

Algorithms. --- Technology assessment.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

health technology assessment --- new horizon --- rational use of medicines --- implementation --- drug utilization research

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At the dawn of the third millennium, we are confronted with a disturbing phenomenon: although global life expectancy still increases, this is not the case for healthy life expectancy! The explanation of this seemingly contradiction is mainly due to the rising prevalence of the new pandemia of chronic non-communicable diseases (NCDs). Even in low and middle income countries, the improvement in healthcare status and life expectancy is paralled by the increase of NCDs, as in all countries worldwide. Since the United Nations General Assembly held in New York in 2011, many publications have emphasized the close link between NCDs and nutrition. The NCDs epidemic forces us to reconsider the public health perspectives. Many governments, non-governmental organizations and other institutions are actively involved in educational nutrition programs and campaigns; however their efforts seldom obtain the results hoped for. It is extremely difficult to induce changes in lifestyle and behavior that have built up over a long period of time. However, it becomes urgent to adapt to our changing life-environment where traditional wisdom and intuitive choices are giving way to individual thinking and search for (often uncontrolled) information. This engenders a number of unprecedented challenges and it calls for a re-appraisal of the existing paradigms to achieve an adequate management of the upstream determinants of health instead of a (pre)dominant medical and hospital-centric approach. In the era of personalized healthcare, it is time to empower policy makers, professionals and citizens for achieving an evidence-based change in the health-disease interface and decision-making process for public health interventions. The scientific and professional society Health Technology Assessment International (HTAi) has recognized nutrition as a health technology by creating a Interest Group (IG) dedicated to research on methodologies and assessments of nutrition-related public health, while taking into account contextual factors (ethical, legal, social, organizational, economic, ...) in order to generate meaningful outcomes for establishing evidence-based health policies. This Research Topic aims to elaborate on some of the potential hurdles which have to be overcome for the sake of sustainable healthcare provisions anywhere in the world, such as shortcomings in methodological approaches, regulatory frameworks, gaps between evidence, its hierarchy and final recommendations for public health management.

nutrition --- sustainable public health --- Health Outcomes --- Cost Effectiveness --- Health Technology Assessment --- Contextual research --- diet quality --- ecosystems health --- Non communicable diseases

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This open access book explores the relevance of the concept of technology assessment (TA) on an international and global level. Technologies play a key role in addressing global challenges such as climate change, population aging, digitization, and health. At the same time, their use increases the need for coordinated action and governance at the global level in the field of science, technology and innovation (STI). Featuring case studies on STI fields such as energy, biotechnology, artificial intelligence, and health technology, as well as TA activities at the national and international levels, this book reflects on the challenges and opportunities of global technology governance. It also provides an in-depth discussion of current governmental STI cultures and systems, societal expectations, and the policy priorities needed to achieve coordinated and effective STI intervention in policymaking and public debate at the global level. Lastly, the book promotes the establishment of a forum for a truly global dialogue of TA practitioners, fostering the articulation of their needs, knowledge and perspectives.

Political structure & processes --- Sociology --- Globalization --- Technology assessment --- Global technology governance --- S&T and globalization --- International technology governance --- Science policy advice --- Innovation governance --- Artificial Intelligence --- Health technology --- Biotechnology --- Reflexive modernization --- Political science. --- Science—Social aspects. --- Globalization. --- Governance and Government. --- Science and Technology Studies. --- Global cities --- Globalisation --- Internationalization --- International relations --- Anti-globalization movement --- Administration --- Civil government --- Commonwealth, The --- Government --- Political theory --- Political thought --- Politics --- Science, Political --- Social sciences --- State, The --- Technology assessment.

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Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Cancer cells with abnormal miRNA expression evolve the capability to sustain proliferative signaling, evade growth suppressors, resist cell death, activate invasion and metastasis, and induce angiogenesis. Genome-wide profiling demonstrates that miRNA expression signatures are associated with tumor type, tumor grade and clinical outcomes, so miRNAs could be potential candidates for diagnostic biomarkers, prognostic biomarkers, therapeutic targets and preventive screening programs. Although miRNAs have multiple targets, their function in tumorigenesis is due to their regulation of a few specific targets. After the first detection of altered miRNA in leukemia, microRNAs have been demonstrated to be constantly altered in all cancer. More recently, microRNA has been shown to be altered by exposure to environmental carcinogens, thus driving the whole process of carcinogenesis. Our aim is to provide a rigorous peer review and publish cutting-edge research on the role of microRNA in cancer prevention therapy to educate and inspire the scientific community worldwide.

breast cancer --- miRNAs --- liquid biopsy --- angiogenesis --- biomarkers --- early diagnosis --- air pollution --- biomarker --- exposure --- human --- lung cancer --- miRNA --- carcinogenesis --- microRNA --- asbestos exposure --- oral squamous cell carcinoma --- diagnosis --- prognosis --- saliva --- neuroblastoma --- MYCN amplification --- metastases --- chemoresistance --- public health genomics --- genetic polymorphisms --- epigenetic modulations --- genetic and microbiome markers --- health technology assessment --- early disease prevention --- nonsmokers lung cancer --- environmental risk factors --- oncogenes --- mutations --- glioblastoma --- microRNAs --- cancer --- qPCR --- cancer stem cells --- plasticizers --- in vitro study --- PRISMA --- no-smokers lung cancer --- DNA adducts --- mesothelioma --- extracellular vesicles --- miR-625 --- fluoro-edenite --- asbestos --- malignant mesothelioma --- cancer prevention --- microbiota --- epigenetics --- environmental pollutants --- cutaneous tissues --- ozone exposure --- n/a