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DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Life Sciences --- Immunology and Microbiology --- Structural Biology --- Proteomics

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The peripheral membrane proteins transduce the extracellular signaling into the cells. The peripheral membrane proteins include the G protein-coupled receptors, receptor tyrosine kinases, channels and transporters. The signals, which are transduced via the peripheral membrane proteins, activate several pathways including G protein signaling, MAPK signaling, TNF signaling, TGF? signaling, Wnt signaling and Hedgehog signaling. The peripheral membrane proteins transduce the signaling from the extracellular ligands into the cells. This book intends to provide a comprehensive overview of the features and signaling of peripheral membrane proteins, which includes the molecular structure and interaction. The insights into membrane proteins associated with diseases and therapeutics and the effects of drugs and chemicals are also discussed in this book.

Peripheral circulation --- Regulation. --- Regulation of peripheral circulation --- Biological control systems --- Life Sciences --- Immunology and Microbiology --- Structural Biology --- Proteomics

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The chapters in this book are written by a team of well-reputed international researchers. The objective is to provide advanced and updated information related to protein-protein interactions. I hope the methods, resources and approaches described here will enhance the available knowledge of the reader significantly.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Life Sciences --- Immunology and Microbiology --- Structural Biology --- Proteomics

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Viruses in the Parvoviridae family constitute one of the most diverse and intriguing fields of research. While they all share an ssDNA genome and a small capsid, they can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. Exploring such diversity and unraveling the inherent complexity in these apparently simple viruses is an ongoing endeavor and commitment for the scientific community. The translational implications of research on parvoviruses are relevant. Within the family, some viruses are important human and veterinary pathogens, in need of diagnostic methods and antiviral strategies; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. This Special Issue of Viruses collects recent contributions in the field of parvovirus research, with a focus on new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, and viral oncotherapy are a selection of the topics addressed in the issue that can be of relevance to the community involved in parvovirus research and of interest to a wider audience.

antivirals --- Bombyx mori bidensovirus --- Bocaparvovirus --- human bocavirus 1 --- equine parvovirus-hepatitis --- NS2 --- NS1 --- X-ray crystallography --- BIRC3 (cIAP-2) --- glycans --- children --- antibody interactions --- new viruses --- alpaca --- cidofovir --- rodent protoparvoviruses --- clinical trials --- structural biology --- DNA virus --- human bocavirus --- caspase-3 --- viral communities --- uncoating --- PLA2 --- phospholipase-A2 --- oncolytic virus immune therapy --- Parvoviridae --- viral ecology --- Cryo-EM --- AAV --- metagenomics --- phylogeny --- oncolytic viruses --- mite --- parvovirus evolution --- Carnivore protoparvovirus 1 --- adeno-associated virus --- telbivudine --- capsid stability --- virus --- homology modeling --- human airway epithelia --- sequence analysis --- acute gastroenteritis --- bisulfite PCR --- next-generation sequencing --- single stranded DNA virus --- overlapping promoters --- virus diversity --- prognosis --- oncolytic activity --- genome --- hydroxyurea --- Lepidoptera --- genome externalization --- antiviral compounds --- circulating angiogenic cells --- tumor microenvironment --- coumarin derivatives --- nuclear targeting --- densovirus --- receptor interactions --- cell cycle arrest --- transcription profile --- brincidofovir --- canine parvovirus --- endogenous viral elements --- inflammatory cardiomyopathy --- erythroid progenitor cells --- RNA-seq --- insect --- chapparvovirus --- RT-qPCR --- trafficking --- AAV2 --- agricultural pests --- Adeno-associated virus --- myocarditis --- diagnosis --- parvovirus --- feline panleukopenia virus --- chitin --- B19V --- transcription mapping --- flavonoids --- immunomodulation --- erythrovirus --- apoptosis --- adenoviral vector --- anti-cancer --- divalent cations --- protease --- genetics --- preclinical --- arthropod --- peritrophins --- biocontrol --- dilated cardiomyopathy --- insect parvovirus --- combination therapies --- intravenous immunoglobulin (IVIG) --- virus phylogeny --- evolution --- second generation parvovirus treatments --- commercial horse serum --- parvovirus B19 --- canine chapparvovirus --- CpG methylation --- RACE --- H-1PV --- viral metagenomics --- horses