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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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This monograph concerns the mathematical aspects of software reliability and quality assurance and consists of 11 technical papers in this emerging area. Included are the latest research results related to formal methods and design, automatic software testing, software verification and validation, coalgebra theory, automata theory, hybrid system and software reliability modeling and assessment.
fuzzy automata --- coalgebra --- fuzzy language --- bisimulation --- composition --- test data generation --- genetic algorithm --- specification-based testing --- regression testing --- mutation testing --- eventual property --- model checking --- Maude --- textual question answering --- visual question answering --- metamorphic testing --- metamorphic relations --- quality assessment --- software rejuvenation --- checkpointing --- optimal rejuvenation-trigger timing --- steady-state system availability --- phase expansion --- human-error factors --- petri net --- concurrent software systems --- model-checking --- data-flows --- software reliability model --- maximum likelihood estimation --- EM algorithm --- non-homogeneous Poisson process --- generalized failure count data --- moth flame optimization --- island-based model --- feature selection --- software defect prediction --- software reliability --- search-based test case generation --- branch coverage --- object-oriented --- deep learning --- long short-term memory --- project similarity and clustering --- cross-project prediction --- Nervos CKB --- consensus protocol --- UPPAAL
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Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
advanced glycated end products --- microRNAs --- n/a --- differentiation --- transcription --- skin absorption --- cellular quiescence --- lifespan --- longevity genes --- protein kinases --- self-renewal --- circadian --- blood–brain barrier --- aging-related disorders --- sirtuin-1 --- inflammation --- arterial aging --- reactive oxygen species --- electron microscopy --- reconstructed human skin --- rejuvenation --- low-dose fluvastatin and valsartan combination --- inflammaging --- hematopoietic stem cell aging --- cell cycle --- mitochondria --- ribose --- the nervous system --- nanomedicine --- proteostasis --- adult stem cells --- immunosenescence --- cell signaling --- mechanisms of quiescence maintenance --- metabolism --- aging --- melatonin --- diabetes --- mechanisms of quiescence entry and exit --- Drosophila melanogaster --- GSK3 (glycogen synthase kinase 3) --- blood-brain barrier
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Habitual statements in academic and journalistic fields on the growing inequality of our cities call for multiple reflections. There are numerous indicators of inequality, and territorial specificities give rise to important and subtle differences. What is less debatable is the spatial expansion of inequality (from more outlying, poorer countries to the most developed ones) and its generalization on all scales (from rural to urban areas, and from large metropolises to small cities). Mobility and housing lie at the root of many of these processes, which are represented by phenomena that are often interconnected, such as gentrification and the elite social classes; impoverishment and immigrants in search of work; and segregation and refugees; among many others. In this book, we try to offer a Spanish-based vision of what we call urban geographies in transition—that is, urban geographies in which the key stages, for the purpose of analysis, are the real estate bubble (1996–2007), the subsequent crisis (2008–2013), and the ensuing recovery (2014–2020), without overlooking the impact of the current COVID-19 crisis on the configuration of a new spatial order in cities.
Spanish cities --- economic crisis --- financialization --- gentrification --- housing crisis --- post-Fordist capitalism --- property bubble --- property repossession --- touristification --- pandemic --- real estate dispossession --- mortgage foreclosure --- evictions --- short-term rentals --- housing studies --- critical geography --- Canary Islands --- megaprojects --- neoliberalism --- urban development --- urban planning --- Santa Cruz de Tenerife --- Spain --- tourist gentrification --- real estate market --- international migrations --- tourist rejuvenation --- urban inequality --- master plans --- urban projects --- medium-sized cities --- neoliberal urbanism --- tourist housing --- Airbnb --- historic center --- population --- population growth --- spatial reconfiguration --- large urban areas --- post-crisis period --- urban project --- urban agents --- market urbanism --- speculation --- urban transformation --- central area --- Madrid --- residential segregation --- living conditions --- spatial inequalities --- urbanization process --- environmental justice --- urban parks --- ecosystem services --- Tarragona --- n/a
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Nutritional deficiencies, and different nutritional and dietary lifestyles, whether poor or absent of essential nutrients, aside from excess intake, can lead to inflammatory complications and loss of function. Bioactive compounds are non-nutritional components derived from plants, foods, and beverages with a multitude of biological effects. The improvement of analytical techniques has allowed scientific community to state that the regular consumption of bioactive phytochemicals is related to the prevention of numerous pathologies, through mechanisms that involve oxidative stress reduction, gene expression modulation, and even enzymatic activation inhibition.
quercetin --- nervous system --- molecular signals --- pharmacological potential --- cognitive impairment. --- micronuclei --- radioprotectors --- radiation effects --- melanoma --- PNT2 --- B16F10 cells --- Ulmus parvifolia --- wound healing --- matrix metalloproteinase --- transforming growth factor --- skin rejuvenation --- kaempferol --- naringin --- orientin --- rutin --- vitexin --- chlorogenic acid --- citric acid --- malic acid --- quinic acid --- rosmarinic acid --- curcumin --- nanocurcumin --- neurological disorders --- nanocarriers --- liposomes --- cancer --- diet --- flavonoids --- food supplements --- hormesis --- phytoestrogens --- sulforaphane --- resveratrol --- cardiovascular disease --- nanomedicine --- liposome --- nanoformulation --- RNA-dependent RNA polymerase --- remdesivir --- chloroquine --- SARS-CoV-2 --- COVID-19 --- spike glycoproteins --- Acorus calamus --- ethnomedicinal --- phytochemistry --- toxicity --- pharmacological action --- clinical trial --- neuroprotective --- neurological --- metabolic application --- kurarinone --- coronavirus --- HCoV-OC43 --- autophagy --- infection --- MRC-5 cell --- LC3 --- p62/SQSTM1 protein --- n/a
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In a similar way to many other engineering fields, the road pavement industry strongly affects the critical issues of our generation, including climate change, pollutant emission, the exploitation of natural resources and economic crises. For this reason, technicians and researchers are searching ravenously for sustainable solutions to implement in current road construction systems with the following goals: To reduce the consumption of energy and virgin materials; To run environmentally and economically friendly maintenance; To recycle waste from different industrial processes; To decrease the noise, the pollution and the heat generated by traffic, particularly in urban contexts. This Special Issue aims to collect high-quality studies that combine the aforementioned solutions, including works pertaining to: The hot, warm, and cold recycling of reclaimed asphalt pavement; Marginal materials for asphalt pavements; Innovative sustainable materials; Durability and environmental aspects; Structure performance, modeling and design; Advanced trends in rehabilitation and preservation; Surface characteristics and road safety; Management system/life cycle analysis; Urban heat island mitigation; Energy harvesting.
porous concrete --- metakaolin --- geopolymers --- permeable pavements --- urban drainage systems --- maintenance --- reinforced asphalt pavement --- geogrid --- interlayer bonding --- static shear test --- cyclic shear test --- fatigue properties --- warm mix asphalt --- natural zeolite --- gas emissions --- energy consumption --- production costs --- bituminous mixtures --- nano-additives --- nanoclay --- carbon nanotubes --- graphene nanoplatelets --- nano-calcium oxide --- nano-titanium dioxide --- sonication --- fatigue performance --- self-healing --- hot-mix asphalt --- ageing --- cooling --- temperature segregation --- hauling --- insulated truck --- re-heating --- contact stresses --- rolling resistance --- braking --- free rolling --- load --- inflation pressure --- speed --- porosity --- permeability coefficients --- mixing ratio --- aggregate size --- compressive strength --- computed tomography (CT) image --- ex-post CBA --- road modernisation --- incidence of traffic accidents --- decision-making process --- life cycle assessment --- waste management --- circular economy --- alternative materials --- construction --- road stabilisation --- bearing capacity --- unbound base course --- cold central-plant recycled base course --- falling weight deflectometer (FWD), cold recycling in-plant --- bitumen --- aging --- rejuvenation --- reclaimed asphalt --- recycling --- coal bottom ash --- waste material --- recycle --- construction industry --- civil engineering --- bitumen selection --- performance-graded bitumen --- asphalt pavement temperatures --- temperature maps --- n/a
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Construction materials are the most widely used materials for civil infrastructure in our daily lives. However, from an environmental point of view, they consume a huge amount of natural resources and generate the majority of greenhouse gasses. Therefore, many new and novel technologies for designing environmentally friendly construction materials have been developed recently. This Special Issue, “Environment-Friendly Construction Materials”, has been proposed and organized as a means to present recent developments in the field of construction materials. It covers a wide range of selected topics on construction materials.
fluorescence spectrum --- microstructure --- regeneration --- sensitivity analysis --- asphalt mixes --- limestone aggregates --- bio-oil --- plateau value of dissipated strain energy ratio --- diatomite --- water-leaching pretreatment --- fatigue performance --- ultra-thin wearing course --- recycling aggregate --- design optimization --- induction heating --- vibration noise consumption --- bitumen --- relaxation --- viscous-elastic temperature --- field evaluation --- healing agents --- transmittance --- Ca-alginate microcapsules --- artificially aged asphalt mixture --- sequencing batch Chlorella reactor --- waste concrete --- plant ash lixivium --- steel fiber --- ultra-high performance concrete --- titanate coupling agent --- SEM --- self-healing --- physical properties --- porous pumice --- thermal–mechanical properties --- aggregate morphology --- asphalt mortar --- adhesion energy --- styrene–butadiene–styrene (SBS) modified bitumen --- water solute exposure --- emulsified asphalt --- demulsification speed --- mineral-asphalt mixtures --- aging processes --- phase change materials --- surface texture --- long-term drying shrinkage --- contact angle --- aging depth --- asphalt --- calcium alginate capsules --- nitrogen and phosphorus removal --- micro-morphology --- rice husk ash --- low-temperature --- cement --- hydrophobic nanosilica --- asphalt mixture --- thickness combinations --- layered double hydroxide --- initial self-healing temperature --- environmentally friendly construction materials --- epoxidized soybean oil --- limestone --- chemical evolutions --- temperature sensitivity characteristics --- micro-surfacing --- cement emulsified asphalt mixture --- dynamic characteristics --- high-strength concrete --- flame retardant --- durability --- creep --- damping --- damage constitutive model --- Ultra-High Performance Concrete (UHPC) --- granite aggregate --- diatomite-modified asphalt mixture --- healing model --- asphalt combustion --- freeze-thaw cycle --- SBS-modified bitumen --- workability --- graphene --- flow behavior index --- fluidity --- parametrization --- fatigue property --- rankinite --- railway application --- crystallization sensitivity --- aqueous solute compositions --- pozzolanic reaction --- self-healing asphalt --- recycled material --- artificial neural network --- rheological properties --- molecular dynamic simulation --- building envelopes --- aluminum hydroxide --- crumb rubber --- optimization --- viscoelasticity --- building energy conservation --- diffusing --- anti-rutting agent --- molecular bridge --- engineered cementitious composites (ECC) --- pavement performance --- morphology --- colloidal structure --- hydrophilic nanosilica --- construction materials --- road engineering --- laboratory evaluation --- rejuvenator --- fatigue equation --- aggregates --- three-point bending fatigue test --- energy-based approach --- aggregate from sanitary ceramic wastes --- polyacrylic acid --- mastic --- CO2 --- specific surface area --- aggregate image measurement system --- solubilizer --- flexibility --- simplex lattice design --- SBS/CRP-modified bitumen --- water stability --- fatigue life --- rejuvenating systems --- skid-resistance --- reclaimed asphalt pavement --- rheology --- hydration characteristic --- surface energy --- modified asphalt materials --- asphalt pavement --- stripping test --- SOD --- tensile stresses --- ultraviolet radiation --- basalt fiber --- “blue-shift” --- polyvinyl alcohol --- sanitary ceramics --- dynamic moduli --- aggregate characteristics --- compound modify --- expanded graphite --- steel slag --- induced healing --- thermal property --- effective heating depth --- dissipated strain energy --- MDA --- mechanical behavior --- plateau value of permanent deformation ratio --- long-term field service --- crack healing --- desulphurization gypsum residues --- pavement failure --- rejuvenation --- interfacial transition zone --- combination --- polyethylene glycol --- adsorption --- tensile strains --- cold recycled asphalt mixture --- resistance to deformations --- asphalt-aggregate adhesion --- viscoelastic properties --- damage evolution --- carbonation --- microwave heating --- amorphous silica --- high-modulus asphalt mixture (HMAM) --- hot mix asphalt containing recycled concrete aggregate --- microfluidic --- dynamic responses --- concrete --- asphalt mastic --- crumb rubber powder --- response surface methodology --- nanomaterial --- self-compacting concrete (SCC) --- rutting factor --- X-ray computed tomography --- fiber modification --- overlay tester --- rubber modified asphalt --- ageing --- aged bitumen --- aged asphalt --- recycling --- damage characteristics --- dynamic tests --- permeation --- ageing resistance
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Construction materials are the most widely used materials for civil infrastructure in our daily lives. However, from an environmental point of view, they consume a huge amount of natural resources and generate the majority of greenhouse gasses. Therefore, many new and novel technologies for designing environmentally friendly construction materials have been developed recently. This Special Issue, “Environment-Friendly Construction Materials”, has been proposed and organized as a means to present recent developments in the field of construction materials. It covers a wide range of selected topics on construction materials.
fluorescence spectrum --- microstructure --- regeneration --- sensitivity analysis --- asphalt mixes --- limestone aggregates --- bio-oil --- plateau value of dissipated strain energy ratio --- diatomite --- water-leaching pretreatment --- fatigue performance --- ultra-thin wearing course --- recycling aggregate --- design optimization --- induction heating --- vibration noise consumption --- bitumen --- relaxation --- viscous-elastic temperature --- field evaluation --- healing agents --- transmittance --- Ca-alginate microcapsules --- artificially aged asphalt mixture --- sequencing batch Chlorella reactor --- waste concrete --- plant ash lixivium --- steel fiber --- ultra-high performance concrete --- titanate coupling agent --- SEM --- self-healing --- physical properties --- porous pumice --- thermal–mechanical properties --- aggregate morphology --- asphalt mortar --- adhesion energy --- styrene–butadiene–styrene (SBS) modified bitumen --- water solute exposure --- emulsified asphalt --- demulsification speed --- mineral-asphalt mixtures --- aging processes --- phase change materials --- surface texture --- long-term drying shrinkage --- contact angle --- aging depth --- asphalt --- calcium alginate capsules --- nitrogen and phosphorus removal --- micro-morphology --- rice husk ash --- low-temperature --- cement --- hydrophobic nanosilica --- asphalt mixture --- thickness combinations --- layered double hydroxide --- initial self-healing temperature --- environmentally friendly construction materials --- epoxidized soybean oil --- limestone --- chemical evolutions --- temperature sensitivity characteristics --- micro-surfacing --- cement emulsified asphalt mixture --- dynamic characteristics --- high-strength concrete --- flame retardant --- durability --- creep --- damping --- damage constitutive model --- Ultra-High Performance Concrete (UHPC) --- granite aggregate --- diatomite-modified asphalt mixture --- healing model --- asphalt combustion --- freeze-thaw cycle --- SBS-modified bitumen --- workability --- graphene --- flow behavior index --- fluidity --- parametrization --- fatigue property --- rankinite --- railway application --- crystallization sensitivity --- aqueous solute compositions --- pozzolanic reaction --- self-healing asphalt --- recycled material --- artificial neural network --- rheological properties --- molecular dynamic simulation --- building envelopes --- aluminum hydroxide --- crumb rubber --- optimization --- viscoelasticity --- building energy conservation --- diffusing --- anti-rutting agent --- molecular bridge --- engineered cementitious composites (ECC) --- pavement performance --- morphology --- colloidal structure --- hydrophilic nanosilica --- construction materials --- road engineering --- laboratory evaluation --- rejuvenator --- fatigue equation --- aggregates --- three-point bending fatigue test --- energy-based approach --- aggregate from sanitary ceramic wastes --- polyacrylic acid --- mastic --- CO2 --- specific surface area --- aggregate image measurement system --- solubilizer --- flexibility --- simplex lattice design --- SBS/CRP-modified bitumen --- water stability --- fatigue life --- rejuvenating systems --- skid-resistance --- reclaimed asphalt pavement --- rheology --- hydration characteristic --- surface energy --- modified asphalt materials --- asphalt pavement --- stripping test --- SOD --- tensile stresses --- ultraviolet radiation --- basalt fiber --- “blue-shift” --- polyvinyl alcohol --- sanitary ceramics --- dynamic moduli --- aggregate characteristics --- compound modify --- expanded graphite --- steel slag --- induced healing --- thermal property --- effective heating depth --- dissipated strain energy --- MDA --- mechanical behavior --- plateau value of permanent deformation ratio --- long-term field service --- crack healing --- desulphurization gypsum residues --- pavement failure --- rejuvenation --- interfacial transition zone --- combination --- polyethylene glycol --- adsorption --- tensile strains --- cold recycled asphalt mixture --- resistance to deformations --- asphalt-aggregate adhesion --- viscoelastic properties --- damage evolution --- carbonation --- microwave heating --- amorphous silica --- high-modulus asphalt mixture (HMAM) --- hot mix asphalt containing recycled concrete aggregate --- microfluidic --- dynamic responses --- concrete --- asphalt mastic --- crumb rubber powder --- response surface methodology --- nanomaterial --- self-compacting concrete (SCC) --- rutting factor --- X-ray computed tomography --- fiber modification --- overlay tester --- rubber modified asphalt --- ageing --- aged bitumen --- aged asphalt --- recycling --- damage characteristics --- dynamic tests --- permeation --- ageing resistance
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Construction materials are the most widely used materials for civil infrastructure in our daily lives. However, from an environmental point of view, they consume a huge amount of natural resources and generate the majority of greenhouse gasses. Therefore, many new and novel technologies for designing environmentally friendly construction materials have been developed recently. This Special Issue, “Environment-Friendly Construction Materials”, has been proposed and organized as a means to present recent developments in the field of construction materials. It covers a wide range of selected topics on construction materials.
fluorescence spectrum --- microstructure --- regeneration --- sensitivity analysis --- asphalt mixes --- limestone aggregates --- bio-oil --- plateau value of dissipated strain energy ratio --- diatomite --- water-leaching pretreatment --- fatigue performance --- ultra-thin wearing course --- recycling aggregate --- design optimization --- induction heating --- vibration noise consumption --- bitumen --- relaxation --- viscous-elastic temperature --- field evaluation --- healing agents --- transmittance --- Ca-alginate microcapsules --- artificially aged asphalt mixture --- sequencing batch Chlorella reactor --- waste concrete --- plant ash lixivium --- steel fiber --- ultra-high performance concrete --- titanate coupling agent --- SEM --- self-healing --- physical properties --- porous pumice --- thermal–mechanical properties --- aggregate morphology --- asphalt mortar --- adhesion energy --- styrene–butadiene–styrene (SBS) modified bitumen --- water solute exposure --- emulsified asphalt --- demulsification speed --- mineral-asphalt mixtures --- aging processes --- phase change materials --- surface texture --- long-term drying shrinkage --- contact angle --- aging depth --- asphalt --- calcium alginate capsules --- nitrogen and phosphorus removal --- micro-morphology --- rice husk ash --- low-temperature --- cement --- hydrophobic nanosilica --- asphalt mixture --- thickness combinations --- layered double hydroxide --- initial self-healing temperature --- environmentally friendly construction materials --- epoxidized soybean oil --- limestone --- chemical evolutions --- temperature sensitivity characteristics --- micro-surfacing --- cement emulsified asphalt mixture --- dynamic characteristics --- high-strength concrete --- flame retardant --- durability --- creep --- damping --- damage constitutive model --- Ultra-High Performance Concrete (UHPC) --- granite aggregate --- diatomite-modified asphalt mixture --- healing model --- asphalt combustion --- freeze-thaw cycle --- SBS-modified bitumen --- workability --- graphene --- flow behavior index --- fluidity --- parametrization --- fatigue property --- rankinite --- railway application --- crystallization sensitivity --- aqueous solute compositions --- pozzolanic reaction --- self-healing asphalt --- recycled material --- artificial neural network --- rheological properties --- molecular dynamic simulation --- building envelopes --- aluminum hydroxide --- crumb rubber --- optimization --- viscoelasticity --- building energy conservation --- diffusing --- anti-rutting agent --- molecular bridge --- engineered cementitious composites (ECC) --- pavement performance --- morphology --- colloidal structure --- hydrophilic nanosilica --- construction materials --- road engineering --- laboratory evaluation --- rejuvenator --- fatigue equation --- aggregates --- three-point bending fatigue test --- energy-based approach --- aggregate from sanitary ceramic wastes --- polyacrylic acid --- mastic --- CO2 --- specific surface area --- aggregate image measurement system --- solubilizer --- flexibility --- simplex lattice design --- SBS/CRP-modified bitumen --- water stability --- fatigue life --- rejuvenating systems --- skid-resistance --- reclaimed asphalt pavement --- rheology --- hydration characteristic --- surface energy --- modified asphalt materials --- asphalt pavement --- stripping test --- SOD --- tensile stresses --- ultraviolet radiation --- basalt fiber --- “blue-shift” --- polyvinyl alcohol --- sanitary ceramics --- dynamic moduli --- aggregate characteristics --- compound modify --- expanded graphite --- steel slag --- induced healing --- thermal property --- effective heating depth --- dissipated strain energy --- MDA --- mechanical behavior --- plateau value of permanent deformation ratio --- long-term field service --- crack healing --- desulphurization gypsum residues --- pavement failure --- rejuvenation --- interfacial transition zone --- combination --- polyethylene glycol --- adsorption --- tensile strains --- cold recycled asphalt mixture --- resistance to deformations --- asphalt-aggregate adhesion --- viscoelastic properties --- damage evolution --- carbonation --- microwave heating --- amorphous silica --- high-modulus asphalt mixture (HMAM) --- hot mix asphalt containing recycled concrete aggregate --- microfluidic --- dynamic responses --- concrete --- asphalt mastic --- crumb rubber powder --- response surface methodology --- nanomaterial --- self-compacting concrete (SCC) --- rutting factor --- X-ray computed tomography --- fiber modification --- overlay tester --- rubber modified asphalt --- ageing --- aged bitumen --- aged asphalt --- recycling --- damage characteristics --- dynamic tests --- permeation --- ageing resistance
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