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Natural compounds, from terrestrial and marine sources, are the result of an evolutionary process which originated in compounds with great structural diversity, multiple biological activities and miscellaneous applications. A large and very active research field is dedicated to identifying biosynthesized compounds; to improve/develop new methodologies to produce/reuse natural compounds; to assess their potential; and to understand their mechanism of action. This Special Issue brings together excellent original and review works, focused on the most recent advances related to the secondary metabolites’ composition of natural sources, and the proposal of new applications for their constituents, such as therapeutic agents, and pesticides or food ingredients.

heterologous expression --- Streptomyces --- secondary metabolite --- Garcinia xanthochymus --- growth inhibitory compounds --- allelopathy --- vanillic acid --- methyl phloretate --- allelopathic activity --- growth inhibitor --- phenolic compounds --- bioherbicide --- sustainable agriculture --- pulsed electric fields --- green extraction --- microalgae --- antioxidants --- pigments --- thymoquinone --- UHRF1 --- ubiquitination --- HAUSP --- tumor suppressor genes --- aaptoline B --- pyrroloquinoline --- Ag(I)-catalyzed cycloisomerization --- dopaminergic neuroprotection --- Parkinson’s disease --- bioactive compounds --- cardiovascular --- nanodelivery --- bioavailability --- Ailanthus altissima --- biological properties --- analytical techniques --- potential applications --- propolis contamination --- propolis cytotoxicity --- antimicrobial activity --- antiprotozoal activity --- artepelin C --- formononetin --- pinocembrin --- quercetin --- kaempferol --- propolis extract --- Asparagopsis armata --- Rhodophyta --- GC-MS --- UHPLC-MS --- dibrominated compounds --- 1,4-dibromobuten-1-ol --- palmitic acid --- brominated phenolics --- red seaweed --- invasive seaweed --- invasive species --- flowers --- antioxidant --- microbial activity --- bioactivity --- enzyme inhibitory potential --- acetylcholinesterase --- lipase --- α-glucosidase --- n/a --- Parkinson's disease

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This book includes recent research activities in the field of food quality assurance and shelf-life extension. The goal is to broaden our current knowledge of advanced approaches to guaranteeing the maintenance of the properties of packaged products during storage. Preservation strategies based on vacuum packaging, innovative active packaging, emerging technologies, and horticultural by-products are widely discussed in specific chapters. Taken together, these research studies constitute clear evidence that achieving food shelf-life extension is still a complex and multifaceted process. The book reflects advances made in the field and, with the addition of a chapter also covering the secondary shelf-life topic, it will provide the latest research for academics working in the field of novel processing, antimicrobial/antioxidant substances, by-product recycling and active packaging. The research collected in this book is ideal for those working in the food quality industry.

olive oil by-products --- breaded fish --- fish shelf life --- fish quality --- sustainable food --- film --- whey protein isolate --- tarragon essential oil --- brook trout --- refrigerated storage --- physicochemical quality --- microbiological quality --- sensory quality --- shelf-life --- sweet cherry --- nanoemulsion coating --- cracking --- fruit quality, nutraceutical value --- crosslinking --- fresh fish --- spoilage --- chilling/refrigeration --- freezing --- edible coatings --- hyperbaric storage --- algae extracts --- antioxidants --- fish preservatives --- total carotenoids --- total phenolics --- trout fillets --- Ceylon spinach --- Basella alba --- ultrasonication --- antioxidant --- antibacterial activity --- pork --- Sus scrofa --- household food waste --- stability evaluation --- sensory acceptability --- period after opening (PAO) --- blackberry --- gray mold --- pathogens --- storage quality --- ozone treatment --- enoki mushroom --- ZnONPs --- propolis --- pullulan/chitosan --- antibacterial --- antioxidant activity --- meat packaging --- volatile organic compounds --- HS-SPME-GC/MS --- Italian sparkling wines --- cork stoppers --- bottle aging --- antimicrobial polymers --- antimicrobial peptides --- food safety --- food packaging --- instrumental color --- overwrapped packaging --- simulated retail display --- TBARS --- vacuum packaging --- fruit and vegetable by-products --- food shelf life --- by-products recycling --- n/a

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The development of new foods or nutraceuticals with health benefits is among today’s most important issues, which presents an opportune moment for the food and/or pharmaceutical industries. However, the launch of new products should be supported by strong scientific evidence on the health benefits attributable to the intake of these bioactive food ingredients. Studies focusing on changes during the storage conditions, digestion process, intestinal absorption rates, biological mechanisms of action, or bioactivity of their metabolites are also required to establish the real contribution of these compounds to the health status of today’s societies

phytochemicals --- antioxidant --- antinausea --- antiobesity --- anticancer --- anti-inflammatory --- ‘Cara Cara’ juice --- storage --- hydrophilic and lipophilic antioxidant --- carotenoid --- flavonoid --- degradation --- dried distilled spent grain (DDSG) --- melanoidins --- content --- structure --- antioxidant activity --- ACE-inhibitory activity --- beverages --- brewing method --- antioxidant potential --- total polyphenols content --- mineral composition --- grape stem --- phenolic compounds --- central composite rotatable design --- sustainable food systems --- pressurized liquid extraction --- side streams valorisation --- curcumin --- milk proteins --- nanoparticles --- antimicrobial activities --- bioactive peptides --- hypertension --- functional food --- metabolic syndrome --- microbiota --- insulin sensitivity --- polyphenols --- grape pomace --- donkey milk (DM) --- donkey colostrum (DC) --- mammal’s milk --- cow’s milk protein allergy (CMPA) --- biologic activity --- immunosenescence --- health benefits --- cryoconcentration --- calafate juice --- storage time --- physicochemical properties --- bioactive compounds --- sensorial analysis --- apitherapy --- royal jelly --- propolis --- bee pollen --- sarcopenia --- dietary interventions --- muscle --- skeletal --- muscle wasting --- physical performance --- coronavirus disease 2019 --- COVID-19 --- body composition --- lean body mass --- insulin resistance --- mitochondrial dysfunction --- satellite stem cells --- polysaccharide purification --- anti-obesity --- proliferation --- PPARγ --- biological activities --- isolation --- analysis --- mechanism of action --- bioaccessibility --- intestinal absorption --- bioavailability

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There is a close link between food and territory. The current challenges are located in precision agriculture and food metrology from the perspective of monitoring and improving food quality, and addressing the promotion of diversity of agroecosystems and diets. Research studies describing factors affecting food quality—such as agronomic conditions, post-harvest elicitors, cultivar selection, harvest date, or environmental influences—are welcome. Sustainable environmental and innovative practices should be promoted. Advanced techniques, such as mass spectrometry, infrared, and Raman spectroscopy in the monitoring and control of foodstuffs to model the agrofood system should be considered. Innovative green technologies should be taken into account. Targeting food approaches should be promoted. Chemometrics applications are welcome. This issue promotes highly interdisciplinary studies, including disciplines from agriculture and biology, chemistry, and nutrition. All types of articles, such as original research, opinions, and reviews, are welcome.

herbal medicinal product --- dried extract --- spouted bed drying --- antioxidant activity --- Rosmarinus officinalis --- powder properties --- Manzanilla --- Tefahi --- Gelb Elfarroudj cultivar --- secoiridoids --- radical scavenging --- UHPLC-HESI-MS --- phenolics --- phenolic compounds --- resveratrol --- linear discriminant analysis --- production–maturation mode discrimination --- amino acids --- fatty acids --- oil --- protein --- starch --- Zea mays L. --- camu-camu powder --- meat --- pH --- S. enterica ser. Typhimurium --- spoilage bacteria --- TBARS --- rapeseed/wheat–rice rotation system --- nitrogen management --- rice yield --- rice quality --- sugars --- carotenoids --- phenolic --- antioxidants --- nutritional quality --- high temperature --- NaCl --- nitrogen fertilizer --- japonica rice cultivars --- grain quality --- starch physicochemical properties --- honey --- physicochemical properties --- colour --- minerals --- trace elements --- ferric reducing-antioxidant power assay --- radical scavenging activity --- spring wheat --- organic agriculture --- Fusarium spp. --- mycotoxins --- quality of grain --- flour yield --- technological value --- microbiomics --- soil metagenomics --- DNA sequencing --- wilt --- rot --- Punica granatum --- metrology --- agriculture --- food --- biodiversity --- literature quantitative analysis --- antioxidant properties --- bee products --- propolis --- plant sources --- medicinal plants --- n/a --- production-maturation mode discrimination --- rapeseed/wheat-rice rotation system

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In recent years, researchers have shown a special interest in natural products as alternative methods for the prevention, treatment, and/or management of various skin illnesses and disorders, primarily due to their natural availability, efficacity, reduced cost, and minimal toxicity. In a similar vein, synthetic bioactives, as well as small molecules, have been studied in vitro, in vivo, and in clinical studies as potential drugs or supplements. This Special Issue of Nutrients comprises an array of literature reviews, original communications, and studies on the roles of natural products, synthetic bioactives, and small molecules in a variety of skin disorders and diseases, such as aging, atopic dermatitis, cutaneous T-cell lymphomas, melanoma, allergies, hyperpigmentation, inflammation, and more, which were investigated through in vitro and ex vivo approaches, preclinical trials, cell-based assays, and animal models. The mechanisms of action of certain compounds are proposed, while others are currently under investigation. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of skin disorders, the wealth of information published in this Special Issue can act as a springboard for the development of new preventive and therapeutic modalities for the management of skin diseases.

Research & information: general --- Biology, life sciences --- keratinocytes --- rutin --- ascorbic acid --- UV radiation --- proteomics --- 3D cell culture --- borage oil --- triacylglycerol metabolism --- acyl-ceramide --- corneocyte lipid envelope --- epidermis --- anti-melanogenesis --- B16/F10 melanoma cell --- hydroxyoctadecadienoic acid --- Sorghum bicolor --- 3-isobutyl-1-methylxanthine --- mycosis fungoides --- atopic dermatitis --- cutaneous lymphomas --- cornified envelope proteins --- FLG --- microalgae --- Planktochlorella nurekis --- skin cells --- proliferation --- senescence --- holothuroids --- glycosaminoglycans --- inflammation --- ear-inflammation --- whey --- Lactobacillus helveticus --- melanin --- α-melanocyte-stimulating hormone --- tyrosinase --- tyrosinase-related protein 1 --- dopachrome tautomerase --- microphthalmia-associated transcription factor --- cosmetics --- black cumin --- Nigella sativa --- Thymocid® --- skin aging --- glycation --- collagen --- collagenase --- elastase --- melanogenesis --- cosmeceutical --- konjac glucomannan --- ultraviolet B --- human epidermal primary melanocytes --- human embryonic fibroblasts --- anti-inflammatory activity --- antioxidant activity --- Cornus officinalis --- molecular docking --- human high-affinity IgE receptors --- α-MSH --- UVB irradiation --- lotus seedpod extract --- epigallocatechin --- propolis --- skin --- matrix metalloproteinase-1 --- UV --- phosphoinositide 3-kinase --- skin care --- skin health --- bioactive substances --- phytonutrients --- antioxidants --- nutraceuticals --- Perilla frutescens --- cell proliferation --- ultraviolet radiation --- DNA repair --- Lactobacillus plantarum CJLP55 --- acne vulgaris --- sebum --- hydration --- urine bacterial extracellular vesicles --- fungal infections --- nanohydrogel --- polysaccharide --- essential oils --- eggshell membrane --- keratinocyte differentiation --- TRPV --- skin thickness --- Lithospermum erythrorhizon --- NC/Nga --- Th1 --- Th2 --- Th17 --- Th22 --- immune balance --- skin barrier function --- n/a