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This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Microbial genetics. --- Microbial genomics. --- Evolutionary biology. --- Biomathematics. --- Microbial ecology. --- Human genetics. --- Genetics. --- Microbial Genetics and Genomics. --- Evolutionary Biology. --- Genetics and Population Dynamics. --- Microbial Ecology. --- Human Genetics. --- Genetics and Genomics. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Environmental microbiology --- Microorganisms --- Ecology --- Microbiology --- Mathematics --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Genomics --- Microbial genetics --- Genomes --- Biologia molecular --- Biofísica molecular --- Bioquímica molecular --- Biofísica --- Bioquímica --- Histoquímica --- Biologia molecular vegetal --- Codi genètic --- Diagnòstic molecular --- Endocrinologia molecular --- Evolució molecular --- Farmacologia molecular --- Genètica molecular --- Glicòmica --- Metabolòmica --- Microbiologia molecular --- Neurobiologia molecular --- Patologia molecular --- Proteòmica --- Reconeixement molecular --- Biomolècules --- Genoma --- Genoma humà --- Genòmica --- Genomes. --- Genomics. --- Genome research --- Molecular genetics --- Haploidy --- Research --- Microbial Genetics and Genomics --- Evolutionary Biology --- Genetics and Population Dynamics --- Microbial Ecology --- Human Genetics --- Genetics and Genomics --- Comparative genomics --- Metagenomics --- Microbial Population Analysis --- Pangenome Profile --- Supra-Genome Analysis --- Adaptive Evolution --- Computational Tools --- Bioinformatic Genomics --- Core Dispensable Genome --- Selection, Recombination, Composition --- Acquired Resistance --- Bacterial Species Concept --- Genomic Diversity --- Bacterial Ecology, Microevolution --- Open Access --- Pan-metagenomics --- Pan-microbiomics --- Pan-epigenome --- Gene Transfer --- Pan-phenomes --- Microbiology (non-medical) --- Genetics (non-medical) --- Applied mathematics --- Ecological science, the Biosphere --- Medical genetics