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This Special Issue includes 12 high-quality articles containing original research findings in the fields of differential and integro-differential models, numerical methods and efficient algorithms for parameter estimation in inverse problems, with applications to biology, biomedicine, land degradation, traffic flows problems, and manufacturing systems.

conservation laws --- feedback stabilization --- input-to-state stability --- numerical approximations --- nonlocal velocity --- macroscopic models --- traffic data --- gap analysis --- multi-phase models --- Volterra integral equations --- asymptotic-preserving --- numerical stability --- Cellular Potts model --- cell migration --- nucleus deformation --- microchannel device --- regularization theory --- multivariate stochastic processes --- cross-power spectrum --- magnetoencephalography --- MEG --- functional connectivity --- spectral complexity --- soil organic carbon --- RothC --- non-standard integrators --- Exponential Rosenbrock–Euler --- langevin equation --- Mean Field Games system --- kinetic Fokker–Planck equation --- hypoelliptic operators --- Caputo fractional derivative --- Allee effect --- existence and stability --- Hopf bifurcation --- implicit schemes --- optimal design --- soft tissue mechanics --- mutual information --- biaxial experiment --- inverse problems --- information theory --- LWR model --- follow-the-leader model --- phase transition --- creeping --- seepage --- fundamental diagram --- lane discipline --- networks --- aggregation equation --- relaxation limit --- scalar conservation law --- finite volume scheme --- differential equations --- mathematical biology --- microfluidic chip --- applied mathematics --- numerical methods --- computational mathematics --- differential and integro-differential models