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Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential drug targets. Elucidating the dynamic behavior of the components of pathways, and their interactions, is one of the key research areas of systems biology. Biological signaling networks are characterized by a large number of components and an even larger number of parameters describing the network. Furthermore, investigations of signaling networks are characterized by large uncertainties of the network as well as limited availability of data due to expensive and time-consuming experiments. As such, techniques derived from systems analysis, e.g., sensitivity analysis, experimental design, and parameter estimation, are important tools for elucidating the mechanisms involved in signaling networks. This Special Issue contains papers that investigate a variety of different signaling networks via established, as well as newly developed modeling and analysis techniques.
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After the long history of screening, it is becoming difficult to find novel compounds from microorganisms and plants anywhere in the world. Until now, more than about 30,000 marine natural products have been reported. However, with the development of marine natural products research, the hit rate of new compounds is also decreasing. Scientists are now turning their attention to the deep sea, where a high hit rate of novel compounds is expected. Many small compounds and peptides from microorganisms and sponges are with therapeutic activity are shown in this book. This Special Issue Book, “Natural Products from the Deep Sea”, should be useful for the screening of novel and useful compounds from nature.
deep sea marine-derived fungus --- Myrothecium sp. --- myrothecol --- nitric oxide (NO) --- antioxidant activity --- macrolactam --- Deep-Sea-Derived Streptomyces --- abiotic formation --- natural product --- antifungal activity --- Thorectandra choanoides --- tryptophan alkaloid --- indoleamine 2,3-dioxygenase --- aplysinopsins --- GNPS molecular network --- cellular signal transduction --- bioactive metabolite --- deep-sea organisms --- anti-inflammatory agent --- anticancer agent --- Mariana Trench --- Micromonospora provocatoris MT25 --- desferrioxamine --- n-acetylglutaminyl glutamine amide --- 1H-15N 2D-NMR --- genomics --- biosynthetic gene clusters --- stress genes --- crustins --- antibacterial peptides --- hydrothermal vent --- anti-Gram-negative bacteria --- Al-crus 3 and Al-crus 7 --- Trichoderma --- harziane diterpenes --- NO inhibition --- thioester-containing benzoate --- deep-sea-derived fungus --- α-glucosidase inhibitory activity --- docking study
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