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Structural and functional aspects of membranes : the involvement of lipid rafts in Alzheimer's disease pathogenesis : the interplay between protein oligomers and plasma membrane physicochemical features in determining cytotoxicity
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Year: 2013 Publisher: Firenze : Firenze University Press,

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Abstract

Alzheimer's disease (AD) is a common form of dementia characterized by the formation of extracellular senile plaques composed of aggregated amyloid peptide (Aβ). The present studies provide evidence that: cell resistance to amyloid toxicity is related to lipid raft cholesterol content. Cholesterol and GM1, affect the susceptibility of Familial Alzheimer's Disease (FAD) broblasts to Aβ42 oligomers in opposite ways, by modulating amyloid binding to lipid rafts and its subsequent toxic effects. The degree of toxicity of the oligomeric species results from a complex interplay between the structural and physicochemical features of both the oligomers and the cellular membrane. Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity.


Book
Advances in Lipidomics: Biomedicine, Nutrients and Methodology
Authors: --- ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This book contains 12 articles covering biomedicine, nutrition, and the methodology of lipidomics . These works were first published by MDPI in a Special Issue of Metabolites. Phospholipids, sphingolipids, glyosylinositolphosphoceramides, cholesteryl esters, acyl-carnitines, and oxylipins are within the lipid classes accounted for studies regarding liver disease, Wilson disease, kidney disease, cardiovascular disease, adipogenesis, and the role lipids play in cancer and virus infection. High-throughput lipid extraction and guidelines for lipid annotation are addressed in several papers. This book is expected to provide a comprehensive view of the diverse areas where lipidomics looms largest.

Keywords

chronic kidney disease --- leptin --- fatty acids --- adipose tissue --- adipocytes --- adipogenesis --- differential mobility spectrometry (DMS) --- lipidomics --- lipidyzer --- mass spectrometry --- metabolomics --- phenotyping --- Simpson-Golabi-Behmel syndrome (SGBS) --- COX --- CYP450 --- LOX --- oxylipins --- PUFAs --- UPLC-MS/MS --- copper --- Wilson’s disease --- lipidomic --- liquid chromatography --- tandem mass spectrometry --- molecular network --- dry eye disease --- hyperosmolarity --- cardiovascular disease --- heart failure --- myocardial infarction --- obesity --- diabetic cardiomyopathy --- dilated cardiomyopathy --- lipids --- odd chain lipids --- lipid profiling --- Folch --- protein precipitation --- sample preparation --- relative lipid composition (Mol%) --- atopic dermatitis --- SHARPIN-deficient mice --- flow-injection mass-spectrometry --- predictive elastic net --- immunotherapy --- cancer --- biomarkers --- metabolism --- cancer cell membranes --- fatty acid biosynthesis --- essential fatty acids --- desaturase enzymes --- fatty acid signaling --- fatty acid biomarker --- sapienic acid --- sebaleic acid --- molecular nutrition --- inflammation --- drug-induced liver injury --- biomarker --- plasma lipid profiles --- ssRNA+ virus --- membrane fusion --- lipid metabolism --- cholesterol --- sphingolipids --- phosphatidylinositol --- SARS-CoV --- glycolipidomics --- GIPC --- glycosyl inositol phospho ceramides --- Lipid Data Analyzer --- ultra-high pressure liquid chromatography --- high-resolution mass spectrometry --- LC-MS --- automated annotation

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