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This collection of 10 papers includes original as well as review articles focused on the cholinesterase structural aspects, drug design and development of novel cholinesterase ligands, but also contains papers focused on the natural compounds and their effect on the cholinergic system and unexplored effects of donepezil.

Amaryllidaceae --- Narcissus pseudonarcissus cv. Carlton --- alkaloids --- carltonine A–C --- Alzheimer’s disease --- butyrylcholinesterase --- docking studies --- organophosphorus nerve agents --- oxime --- cholinesterase --- reactivation --- ventilation --- pharmacodynamics --- blood-brain barrier crossing --- acetylcholinesterase inhibitors --- bone healing --- osseointegration --- donepezil --- hemostasis --- acetylcholinesterase inhibitor --- dementia --- zebrafish --- behavior --- Alzheimer disease --- antioxidants --- butyrylcholinesterase inhibitors --- molecular modelling --- nutraceuticals --- phytochemicals --- acetylcholinesterase --- slow-binding inhibition --- transition state analog --- organophosphorus --- osmotic stress --- neutron scattering --- molecular dynamics --- MD simulations --- fluorene --- in vitro --- in silico --- multi-target directed ligands --- N-methyl-d-aspartate receptor --- molecular modeling --- reactivators --- reactivation process --- organophosphates --- docking --- hydrolysis --- molecular recognition --- catalysis --- inhibition --- n/a --- carltonine A-C --- Alzheimer's disease