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This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients.

Acute leukemia. --- Leukemia --- Oncology

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Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.

transcription factor --- n/a --- transcription --- self-incompatibility --- cytogenetics --- epigenetics --- selenocysteine --- tea --- AP-2? --- nonsense-mediated decay --- transcriptomics --- Akt1 --- promoter --- cell metabolism --- pediveliger larvae --- Patau Syndrome --- tristetraprolin (TTP) --- long non-coding RNA (lncRNA) --- pregnancy --- G-quadruplex --- glioblastoma --- placenta --- PRDM gene family --- circRNA-disease associations --- bioadhesive --- gene expression --- Crassostrea gigas --- transcription regulation --- cell differentiation --- RNA interference --- transcriptome --- inflammatory response --- FOXO1 --- Adiponectin --- liquid chromatograph-tandem mass spectrometer (LC-MS/MS) --- selenium --- selenocysteine insertion sequence --- inflammation --- selenoproteins --- research methods --- nutritional status --- structures and functions --- CRISPR/Cas9 --- fertilization --- melanin --- differentially expressed genes --- tyrosinase --- posttranscriptional regulation --- major depressive disorder --- human malignancies --- pathway --- CDKN1C --- transcription factors --- p57Kip2 --- enhancer activity --- mouse --- disorders --- high-throughput RNA sequencing (RNA-Seq) --- TCGA data analysis --- RNA-seq --- heterogeneous network --- insect --- and drug design --- therapeutic targets --- mechanisms --- obesity --- Pacific oyster --- Rsh regulon --- common pathway --- Pax3 --- somatic mutations --- nutrition --- molecular docking --- bioinformatics --- interactome --- long non-coding RNAs --- transcriptional regulation --- Pteria penguin (Röding --- Adiponectin receptors --- transcriptome profiling --- 1798) --- N-acyl-l-homoserine lactone --- ppGpp --- tumorigenesis --- sphingomonads --- human --- disease --- adenosine and uridine-rich elements (AREs) --- progress and prospects --- miR-25-3p --- acute leukemia --- Novosphingobium pentaromativorans US6-1 --- microscopy --- cancer --- molecular pathways --- causal inference --- Pteria penguin (Röding