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This Special Issue aims to provide an updated overview of the flourishing ongoing research activity in the field of the chemistry of natural and nature-inspired compounds. Ten of the submitted articles were accepted for publication after peer-review. Interestingly, the published papers cover a wide range of chemical reactions, different scaffolds, and several medicinal chemistry applications. Moreover, this Special Issue gathered contributions from all over the world, testifying the international scientific community’s interest in this topic. I would like to sincerely thank the MDPI staff, particularly Jade Lu and the editorial team of Molbank. I am particularly grateful to the authors that decided to share the results of their research by contributing their manuscript to this Special Issue, and, of course, to the reviewers for their valuable help.

quercetin --- flavonoids --- semi-synthetic --- PDE --- sildenafil --- molecular modeling --- Garcinia porrecta --- Clusiaceae --- xanthone --- Lansium domesticum --- Meliaceae --- MCF-7 --- triterpene onoceranoid --- hydrazone --- (+)-camphor --- valproic acid --- technology --- terpenoid --- anticonvulsant activity --- 1,2,3-triazole --- anticancer --- aminoquinoline --- hybrid compound --- kokosanolide --- tetranortriterpenoid --- C. dichotoma --- antidiabetic --- α-glucosidase --- α-amylase --- docking --- ADMET --- curcumin analog --- organic synthesis --- photophysical properties --- steady-state fluorescence --- DFT calculation --- 7-hydroxy-2H-chromen-2-one --- O-acylation reaction --- coumarin --- lupeol derivative --- benzylidene derivative --- α-glucosidase inhibition --- Oxone® --- n/a

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Medicinal and aromatic plants (MAPs), as open-field crops, play an important role in multifunctional and sustainable agriculture as a result of their low energy requirements for cultivation and their many avenues of use, from the production of nutraceuticals, phytonutrients, and phytotherapy to land valorization. This Special Issue of Agriculture, “Medicinal and Aromatic Plants in Agricultural Research when Considering Multifunctionality and Sustainability Criteria”, aims to illustrate the role of MAPs in agriculture in low-impact farming practices, and the benefits they can generate in terms of functional products. This Special Issue covers all research aspects related to MAPs, including a number of scientific macro-areas, such as agronomy, chemistry and pharmacy, ethnobotany and ethnopharmacology, food and nutrition, and ecology. Key topics in this Special Issue include, but are not limited to, the following: Sustainable agricultural practices of MAPs; Breeding and germplasm preservation of MAPs; The biodiversity of MAPs; The conservation of cultivated and wild MAPs; Ethnobotany and ethnopharmacology; Phytotherapy, phytochemistry, and phytopharmacology; Essential oils and secondary metabolites; Functional foods and MAPs; MAPs and degraded and marginal land recovery; The global marketing of MAPs; The legislation of MAPs.

laurel --- microbial load --- oven drying --- real time monitoring --- sage --- sensor --- spike lavender --- essential oil --- 1,8-cineole --- linalool --- camphor --- edaphic characteristics --- altitude --- latitude --- longitude --- aromatic species --- alternative substrates --- irrigation --- plant habitus --- sustainable cultivation --- Calotropis procera leaves --- chronic inflammatory model --- cytokines --- Freund’s complete adjuvant --- indomethacin --- medicinal and aromatic plants --- crop diversification --- sustainability --- leaf yield --- biofunctional products --- genotypic variability --- extra-virgin olive oil --- aromatic and medicinal plants --- gas-chromatography and mass spectrometry analyses --- antioxidant --- oleic acid --- caper plant --- island of Linosa --- morphological and productive characteristics --- growing --- St. John’s wort --- Hypericum perforatum --- secondary metabolites --- cropping technique --- hops --- Humulus lupulus L. --- Mediterranean environment --- trellising system --- medicinal plant --- industrial crop --- hop shoots --- powdery mildew --- downy mildew --- Japanese beetle --- maypop --- Ficus carica L. --- Taxus cuspidata Sieb. et Zucc. --- medicinal-agroforestry system --- soil enzyme activity --- photosynthesis --- polyphenols --- Berberis --- negative fruits --- organic agriculture --- rooting --- hardwood cuttings --- iron chelates --- n/a --- Freund's complete adjuvant --- St. John's wort