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The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation. A chapter describes imaging biomarkers, their development, advantages and the potential pitfalls associated with their use. In the translation of imaging tools from animals to man regulatory issues have to be addressed, which are dealt with in a separate section. The monograph provides a comprehensive overview on the role of imaging in drug discovery today and discusses major developments and trends both with regard to technologies and applications.

Physical methods for diagnosis --- radiologie --- medische beeldvorming

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The long-anticipated Sixth Edition of Morton Meyers' classic text, Dynamic Radiology of the Abdomen, is more than a revision. While holding to the fundamental theme of previous editions, the Sixth Edition is a new and updated presentation of a book that first introduced a systematic application of anatomic and dynamic principles to the practical understanding and diagnosis of intraabdominal diseases 34 years ago. The authorship of this revised text has been enlarged by the addition of two international authorities on intraabdominal disease processes Chusilp Charnsangavej and Michael Oliphant. The insights introduced by Morton Meyers in the first edition and developed over subsequent editions have ensured the critical position of the radiologist in establishing the diagnosis and clearly established the dynamics and pathways of spread and localization of intraperitoneal infections and malignancies, among other things. The Sixth Edition builds upon this by broadening a vision to encompass global anatomic continuity throughout the abdomen and pelvis. New chapters detail the pattern of lymphatic spread of cancer from primary organs in the abdomen and pelvis Includes new information on the unifying concept of the subperitoneal space of the abdomen and pelvis for clinical applications Over 680 new and updated images and illustrations

Physical methods for diagnosis --- radiologie --- medische beeldvorming

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Chest Imaging offers a concise introduction to radiographic chest procedures through a methodical, pattern-driven approach. Filled with high-resolution images, this practical guide provides a thorough explanation of key terms, concepts, and procedures useful for medical students, radiology residents, and others to learn the basics of the plain film chest x-ray (CXR). The book includes a companion online resource at www.robochest.com designed for use in combination to provide students with numerous examples of clinically significant abnormalities commonly detected on CXRs. Chapters present a structured lexicon to teach students to reproducibly describe radiographic abnormalities of the chest detected on CXRs. Topics present specific combinations of distinct radiographic findings in relation to classes and groupings of pathological etiologies of those findings. Recognizing individual findings and identifying their combination or lack of combination with other findings allows students to learn effective differential diagnoses. Chest Imaging includes hundreds of radiographs, CTs, graphics, mnemonics, differentials, and analogous models to help teach otherwise complex processes and radiographic principles.

Physical methods for diagnosis --- radiologie --- medische beeldvorming

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The new FRCR part 1 Anatomy examination comprises 20 cases/images, with five questions about each. The cases are labelled 01 to 20 and the five questions are labelled (a) to (e). The authors have set out to emulate this format by gathering 200 cases which, from their experience, are representative of the cases on which candidates will be tested. The book consists of 10 tests with 20 cases each, and 5 stem questions each. The answers, along with an explanation and tips, accompany each test at the end of the chapter. This will help candidates to identify the level of anatomical knowledge expected by the Royal College of Radiologists. The aim of this book is not to replace the already available literature in radiological anatomy, but to complement it as a revision guide. Whereas radiological anatomy atlases and textbooks provide images with labels for every possible identifiable structure in an investigation, the cases in this book have only 5 labels, simulating the exam.

Physical methods for diagnosis --- radiologie --- medische beeldvorming

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Although already in its third decade, computed tomography (CT) remains a highly dynamic field. The rapid development of multidetector CT (MDCT) technology has challenged the radiological world, even more so with the increasing use of MDCT angiography and cardiac CT. State-of-the-art MDCT techniques have been further enhanced by innovative post-processing imaging software. The book MDCT Body Anatomy is designed to assist medical residents, imaging technicians, and clinicians. Its nearly 500 axial and multiplanar illustrations comprise a comprehensive MDCT anatomic atlas of the body able to provide prompt answers to imaging anatomy questions. The MDCT anatomy of the chest, abdomen, and pelvis is presented in three different parts, with every image containing an informative legend describing the anatomic section performed.

Physical methods for diagnosis --- radiologie --- medische beeldvorming