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Instant Notes titles focus on core information and are designed to help undergraduate students come to grips with a subject quickly and easily. 'Instant Notes in Medicinal Chemistry' provides concise yet comprehensive coverage for undergraduates studying medicinal chemistry as part of a science, pharmacy or medical course. It is a truly multidisciplinary subject involving such subject specialities as organic chemistry, pharmacology, biochemistry, physiology, microbiology, toxicology, genetics and computer modelling. This book concentrates on the fundamental principles of medicinal chemistry and assumes no more than elementary background of chemistry or biology.

Pharmacosynthesis. Pharmacochemistry --- Pharmaceutical chemistry --- Chimie pharmaceutique --- Klinische chemie --- Pharmaceutical chemistry. --- Chemistry, Pharmaceutical

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This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Biomedicine. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Pharmaceutical Sciences/Technology. --- Medicine. --- Toxicology. --- Pharmaceutical technology. --- Médecine --- Toxicologie --- Techniques pharmaceutiques --- Pharmacology --- Medical care --- Sex differences.

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Doping in Sports. --- Pharmaceutical Preparations. --- Social Medicine. --- Biomedical Enhancement. --- 678 Doping --- 170 --- bio-ethiek --- doping --- drugs --- sportgeneeskunde --- Enhancement Technologies --- Enhancement, Biomedical --- Biomedical Enhancements --- Enhancement Technology --- Enhancements, Biomedical --- Technologies, Enhancement --- Technology, Enhancement --- Medicine, Social --- Public Health --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Drugs --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Pharmacology --- Drug Dosage Calculations --- Sports Blood Doping --- Blood Doping --- Blood Doping, Sports --- Blood Dopings --- Blood Dopings, Sports --- Doping in Sport --- Doping, Blood --- Dopings, Blood --- Dopings, Sports Blood --- Sport, Doping in --- Sports Blood Dopings --- Sports, Doping in --- in Sport, Doping --- in Sports, Doping --- Sports --- Performance-Enhancing Substances --- Ethiek --- Conferences - Meetings --- Bio-ethiek --- 601.22 --- ethiek --- gezondheidszorg --- Professional ethics. Deontology --- geneesmiddelen --- medische ethiek --- Pharmaceuticals --- Doping in Sports --- Pharmaceutical Preparations --- Social Medicine --- Biomedical Enhancement --- Provincie West-Vlaanderen --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Product, Pharmaceutical

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A pharmaceutical scientist's approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound's physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. There are numerous literature resources available to pharmaceutical scientists to educate and provide guidance toward formulations development with poorly water-soluble drugs; however, a single, comprehensive reference is lacking. Furthermore, without access to a vast journal library, the detailed methods used to implement these approaches are not available. The objective of this volume is therefore to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules.

Pharmacology. Therapy --- farmacologie --- Drug Compounding. --- Solubility. --- Biological Availability. --- Chemistry, Pharmaceutical --- Chemical Phenomena. --- methods. --- Drug Compounding --- Solubility --- Biological Availability

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In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged: Microreactor chemistry; Nanotechnology and catalysis research; Microwave-assisted organic synthesis; New developments in solid supported synthesis. This book covers lectures about the theory, use, scope and limitations of these new technologies in chemical synthesis. It provides a useful overview for scientists in the pharmaceutical industry as well as in academic institutions interested in chemical synthesis for drug discovery and development.

Pharmaceutical Preparations --- Technology, Pharmaceutical --- Chemistry, Pharmaceutical --- Pharmaceutical chemistry --- Drugs --- Chimie pharmaceutique --- Médicaments --- chemical synthesis --- Congresses --- methods --- Synthesis --- Synthèse --- Drugs -- Synthesis. --- Pharmaceutical chemistry. --- Technology --- Chemistry --- Chemicals and Drugs --- Investigative Techniques --- Pharmacy --- Pharmacology --- Technology, Industry, and Agriculture --- Health Occupations --- Natural Science Disciplines --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Technology, Industry, Agriculture --- Biochemistry --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Synthesis. --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry. --- Organic chemistry. --- Chemical engineering. --- Medicinal chemistry. --- Nanotechnology. --- Organic Chemistry. --- Industrial Chemistry/Chemical Engineering. --- Medicinal Chemistry. --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Chemistry, Organic. --- Biochemistry. --- Molecular technology --- Nanoscale technology --- High technology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Organic chemistry --- Composition --- Technologie --- Chemistry, pharmaceutical