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Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics. Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.

Neoplasms --- Drug Therapy, Combination. --- Cancer --- Apoptosis. --- Apoptose --- drug therapy. --- Chemotherapy. --- Treatment. --- Chimiothérapie --- Traitement --- Apoptosis --- Drug Therapy, Combination --- Chemotherapy --- Treatment --- drug therapy --- Cancer -- Chemotherapy. --- Cancer -- Treatment. --- Drug Therapy --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell death --- Antineoplastic agents --- Oncology  . --- Cancer - Chemotherapy --- Cancer - Treatment --- Neoplasms - drug therapy

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Now extensively revised and significantly expanded, this second edition of the highly praised Thrombolytic Therapy for Stroke incorporates the knowledge gained from the widespread implementation of large rt-PA for acute stroke trials and demonstrates the power of the new technologies now available, specifically MRI scanning. The authors, all recognized experts internationally known for their contributions to developing thrombolytic therapy, have included much new material on stroke-MRI and computed tomography, and updated all chapters describing the background, use, and nuances of thrombolytic therapy. They present everything one needs to know for proper patient selection, the key to successful treatment. Practical how-to chapters guide the reader in treating acute stroke patients, both with and without thrombolytic therapy, according to the latest findings. As in the first edition, all the facts and data are presented for the reader to consider, with opinion clearly segregated and labeled. New detailed practice cases simulate making the rounds in a world-class stroke center to prepare practitioners to be as ready as possible for their first case. Up to date and highly practical, Thrombolytic Therapy for Acute Stroke, Second Edition offers the practicing physician everything necessary-background, protocols, new technologies, and case studies-for the safe and effective treatment of the emergency stroke patient today.

Cerebrovascular Accident --- Thrombolytic Therapy. --- Cerebrovascular disease --- Thrombolytic therapy. --- Accidents vasculaires cérébraux --- Thrombolyse --- drug therapy. --- Chemotherapy. --- Chimiothérapie --- Cerebrovascular disease -- Chemotherapy. --- Thrombolytic therapy --- Thrombolytic Therapy --- Stroke --- Drug Therapy --- Cerebrovascular Disorders --- Brain Diseases --- Vascular Diseases --- Therapeutics --- Cardiovascular Diseases --- Central Nervous System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Nervous System Diseases --- Neurology --- Medicine --- Health & Biological Sciences --- Chemotherapy --- Fibrinolytic therapy --- Thrombolysis --- Thrombosis --- Apoplexy --- Brain --- Cerebral circulation disorders --- Cerebral vascular accident --- Cerebrovascular accident --- Cerebrovascular disorders --- Cerebrovascular syndrome --- CVA (Disease) --- Blood-vessels --- Medicine. --- Neurology. --- Medicine & Public Health. --- Neglect (Neurology) --- Fibrinolysis --- Nervous system --- Neuropsychiatry --- Neurology .

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The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come.

Histone Deacetylases --- Cell Cycle --- Enzyme Repression --- Neoplasms --- Sirtuins --- Histone deacetylase. --- Cell cycle. --- Enzymes. --- Cancer --- Histone désacétylase --- Cycle cellulaire --- Enzymes --- physiology. --- drug effects. --- antagonists & inhibitors. --- drug therapy. --- Chemotherapy. --- Chimiothérapie --- Cancer -- Chemotherapy. --- Histone deacetylase --- Cell cycle --- Cell Physiological Processes --- Gene Expression Regulation, Enzymologic --- Enzyme Inhibitors --- ADP Ribose Transferases --- Amidohydrolases --- Group III Histone Deacetylases --- Biological Science Disciplines --- Intracellular Signaling Peptides and Proteins --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Molecular Mechanisms of Pharmacological Action --- Pentosyltransferases --- Proteins --- Gene Expression Regulation --- Cell Physiological Phenomena --- Hydrolases --- Disciplines and Occupations --- Glycosyltransferases --- Amino Acids, Peptides, and Proteins --- Pharmacologic Actions --- Phenomena and Processes --- Genetic Processes --- Transferases --- Chemical Actions and Uses --- Enzymes and Coenzymes --- Genetic Phenomena --- Chemicals and Drugs --- Drug Therapy --- Histone Deacetylase Inhibitors --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Chemotherapy --- Biocatalysts --- Ferments --- Soluble ferments --- Mitotic cycle --- Nuclear cycle (Cytology) --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Antineoplastic agents --- Catalysts --- Enzymology --- Biological rhythms --- Amidases --- Treatment --- Oncology. --- Tumors --- Cancer research