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In recent years, elucidation of many exciting details of the complex cellular and molecular processes involved in the initiation, progression, and clinical and biological behavior of brain tumors has greatly deepened our understanding of these cancers, and is now leading to new paradigms in their diagnosis and treatment. In Brain Tumors, Francis Ali-Osman, DSc, has assembled a panel of leading experts to summarize and illuminate the full range of recent research advances in their rapidly evolving field, with particular emphasis on those that are providing novel insights into the disease. The chapters critically assess current knowledge and the challenges of the future in relevant areas of brain research, including basic mechanisms of neuro-oncogenesis, molecular neurobiology, genetics, epidemiology, pathology, immunology, and therapy. New knowledge is critically presented on molecular profiling, molecular pathology and classification, in vitro and in vivo brain tumor models, brain metastasis, and progenitor cell biology. They also discuss in depth the cellular and genetic pathways involved in brain oncogenesis, malignant progression, and therapeutic response, highlighting oncogenes and tumor suppressor genes, DNA damage and repair, invasion and migration, cell cycle, growth factors, signaling, apoptosis, and developmental biology. The discussion of brain tumor therapy focuses on advances in pharmacological thinking, therapeutic modalities, novel therapeutic targets, rational drug design, gene and viral therapies, drug delivery and the blood-brain barrier, immunotherapy, and brain imaging. Authoritative and comprehensive, Brain Tumors provides an essential state-of-the-art guide to productive work across the entire range of basic and clinical research in neuro-oncology today. For the both active researcher and the trainee, the book will provide an appreciation of new neuro-oncology concepts and facilitate incorporating them into their own ongoing research.

Brain Neoplasms. --- Brain --- Cerveau --- Tumors. --- Tumeurs --- Brain -- Tumors. --- Brain Diseases --- Central Nervous System Neoplasms --- Nervous System Neoplasms --- Central Nervous System Diseases --- Nervous System Diseases --- Neoplasms by Site --- Diseases --- Neoplasms --- Brain Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Tumors --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Oncology. --- Cancer research

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Neurocritical Care: A Guide to Practical Management provides clear and concise guidelines for the clinician, on the management of adult brain injured patients. It steers the clinician through the complicated decisions that are demanded in these cases, involving initial assessment, interpretation of radiological investigations, referral to a Regional Neurosurgical Center, prevention of secondary brain injury and the management of complex clinical scenarios such as Status epilepticus. This book will prove an indispensible aid for making these critical decisions. Including tried and tested proformas for swift and accurate communication of information to Regional Neurosurgical Centers, this book equips the clinician to get the most out of these specialist services. This book also addresses the difficult area of defining futility and withdrawal of care, ranging from the role of neuro-radiological imaging in aiding these decisions to a discussion of the complex ethical dilemmas that the clinician is inevitably faced with. A comprehensive easy-reference, Neurocritical Care is essential reading for those working within the primary referring centre in Emergency Medicine, Anesthesia, Intensive Care and Surgery. John P. Adams, MB ChB MRCP FRCA ATLS PGD - MedSch (Anesthesia) is Consultant Anesthetist with an interest in Neuroanesthesia and Anesthesia for Endocrine Surgery at Leeds Teaching Hospitals NHS Trust, UK. Dominic Bell, FFA.RCS MB ChB MPhil is Consultant in Intensive Care and Anesthesia at Leeds Teaching Hospitals NHS Trust, UK. Justin McKinlay, MA (Oxon) BM Bch FRCA is Consultant Anesthetist and Honorary Senior Lecturer at Leeds Teaching Hospitals NHS Trust, UK.

Anesthesiology --- Radiotherapy. Isotope therapy --- Neuropathology --- Surgery --- neurologie --- hersenen --- anesthesie --- neurochirurgie --- radiologie --- Brain Injuries --- Critical Care --- Neurological intensive care --- Brain --- Soins intensifs en neurologie --- Cerveau --- therapy. --- methods. --- Wounds and injuries. --- Lésions et blessures --- EPUB-LIV-FT LIVMEDEC SPRINGER-B

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The recent explosive growth in the study of status epilepticus (SE), an epileptic seizure that threatens to produce new seizures, has shown that SE is not a single disease, but arises from different substrates of the brain and comprises multifaceted illnesses. In Status Epilepticus: A Clinical Perspective, a panel of senior clinicians critically reviews the many forms of SE, their causes, manifestations, methods of diagnosis, and appropriate treatments. The authors emphasize the disease as encountered by the clinician in the field and the importance of correct recognition and diagnosis. They provide for each form of SE the underlying genetic, biological, and developmental background, the pathophysiological processes, as well as the precipitating factors that lead to an episode. For the difficult problem of diagnosing nonconvulsive SE, they offer detailed syndrome classifications, differential diagnoses, descriptions of seizure "imitators," notes on unusual behavioral and cognitive manifestations, and carefully delineated clinical presentations. Additional highlights include striking EEG reproductions that provide classic examples of patients in SE, SE in very young children and neonates, and an analysis of the cellular physiology and processes occurring during SE. Comprehensive and up-to-date, Status Epilepticus: A Clinical Perspective offers the neurologic clinician an authoritative review of the diagnosis and treatment of the many forms of this most serious and challenging acute nervous system disorder.

Status Epilepticus. --- Epilepsy. --- Convulsions. --- Epilepsie --- Convulsions --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Medicine. --- Neurology. --- Medicine & Public Health. --- Brain --- Developmental disabilities --- Spasms --- Nervous system --- Epilepsy --- Diseases --- Medicine --- Neuropsychiatry --- Neurology .

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Scientists no longer accept the existence of a distinct moral organ as phrenologists once did. A generation of young neurologists is using advanced technological medical equipment to unravel specific brain processes enabling moral cognition. In addition, evolutionary psychologists have formulated hypotheses about the origins and nature of our moral architecture. Little by little, the concept of a ˜moral brain' is reinstated. As the crossover between disciplines focusing on moral cognition was rather limited up to now, this book aims at filling the gap. Which evolutionary biological hypotheses provide a useful framework for starting new neurological research? How can brain imaging be used to corroborate hypotheses concerning the evolutionary background of our species? In this reader, a broad range of prominent scientists and philosophers shed their expert view on the current accomplishments and future challenges in the field of moral cognition and assess how cooperation between neurology and evolutionary psychology can boost research into the field of the moral brain.

Biological Evolution. --- Brain --- Cognition --- Cognitive neuroscience --- Cultural Evolution. --- Emotional Intelligence. --- Ethics. --- Evolution. --- Evolutionary psychology. --- Moralischer Sinn. --- Morals. --- Neuropsychology. --- Physiologische Psychologie. --- Localization of functions. --- physiology. --- Moral and ethical aspects.

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Brain injury remains one of the most dreaded complications of cardiac surgery. The range of injury is broad; while a stroke may be easily defined and diagnosed, more subtle injuries most definitely occur. There remains debate as to how these are diagnosed and there is a lack of standard definitions allowing inter-study comparison. If we are to have confidence in strategies that may reduce brain injury, we need to have confidence in the end-points used to define that injury. We need to better understand the phenomena associated with neuropsychometric testing; we need to fully elucidate the relationship between structural brain injury, embolism counting, and surrogate biomarkers; and we need an improved understanding of the clinical significance of abnormalities detected on postoperative magnetic resonance imaging. Brain Protection in Cardiac Surgery presents a detailed background of studies of neurological morbidity and neuroprotection from a range of experts in the field of neuroprotection, providing a detailed reference for clinicians in the field. The Editors have detailed connections between the different strands of injury be it the pathology, the imaging, the clinical and cognitive examination, potential biomarkers and have then provided summary reports of treatment strategies that may reduce such injury. As we look to the future, the design of studies attempting to reduce such injury becomes increasingly important and this book provides the fundamental background information to fuel interest, initiate novel prevention and therapeutic strategies, and inform the investigator how to develop and design their research study.

Neuropathology --- medische beeldvorming --- cardiologie --- neurologie --- Surgery --- hersenen --- Human medicine --- Radiotherapy. Isotope therapy --- radiologie --- hartchirurgie --- geneeskunde --- Pathology of the circulatory system --- Physical methods for diagnosis --- Brain Injuries --- Cardiovascular Surgical Procedures. --- Intraoperative Complications. --- Heart --- Brain damage --- Coeur --- Cerveau --- prevention & control. --- Complications --- Prevention --- Chirurgie --- Complications et séquelles --- Lésions et blessures --- Prévention --- EPUB-LIV-FT LIVMEDEC SPRINGER-B