Listing 1 - 2 of 2 |
Sort by
|
Choose an application
The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
History of human medicine --- Immunology. Immunopathology --- immunologie --- farmacologie --- Cell receptors. --- Cell receptors --- Physiological effect. --- Receptors cel·lulars --- Receptors cel·lulars.
Choose an application
'Protein & Cell' is a monthly, peer-reviewed, open access journal that publishes original research articles, reviews, and commentaries concerning the latest developments in multidisciplinary areas in biology and biomedicine, with an emphasis on protein and cell research.
Cell Physiological Phenomena. --- Cells. --- Proteins. --- Cytology --- Cytologie --- Periodicals. --- Périodiques --- Cytology. --- Life Sciences --- Biochemistry --- Biophysics --- Protein Science --- Cell Biology --- Stem Cells --- Human Genetics --- Developmental Biology --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiological Processes --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Cell --- Cell Biology --- physiology --- Proteïnes. --- Citologia. --- Enginyeria biomèdica. --- Cell Physiological Phenomena --- Proteins --- Enginyeria biomèdica --- Proteïnes --- Citologia --- Revistes. --- Investigació --- Protein --- biochemistry --- protein science --- cell biology --- stem cells --- human genetics --- developmental biology --- Histology. Cytology --- General biochemistry --- Enginyeria clínica --- Enginyeria mèdica --- Bioenginyeria --- Biofísica --- Enginyeria --- Medicina --- Electrònica mèdica --- Enginyeria de teixits --- Materials biomèdics --- Aparells i instruments mèdics --- Biologia cel·lular --- Biologia --- Citogenètica --- Citoquímica --- Migració cel·lular --- Cèl·lules --- Cèl·lules animals --- Ultraestructura (Biologia) --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica --- Medicine --- Health Workforce
Listing 1 - 2 of 2 |
Sort by
|