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PI3K and AKT Isoforms in Immunity : Mechanisms and Therapeutic Opportunities
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ISBN: 9783031065668 9783031065651 9783031065675 9783031065682 Year: 2022 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Abstract

This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.


Periodical
Journal of molecular signaling
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ISSN: 17502187 Publisher: London


Periodical
JAK-STAT
ISSN: 21623996 21623988 21623945 2162397X

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Periodical
Journal of receptor and signal transduction research
ISSN: 10799893 Publisher: New York

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Keywords

Binding sites (Biochemistry) --- Cell receptors --- Cellular signal transduction --- Sites actifs (Biochimie) --- Récepteurs cellulaires --- Transduction du signal cellulaire --- Periodicals --- Périodiques --- Receptors, Cell Surface. --- Receptors, Drug. --- Signal Transduction. --- Cell receptors. --- Cellular signal transduction. --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Drug Receptor --- Drug Receptors --- Receptor, Drug --- Pharmaceutical Preparations --- Cell Surface Hormone Receptors --- Endogenous Substances Receptors --- Cell Surface Receptors --- Hormone Receptors, Cell Surface --- Receptors, Endogenous Substances --- Binding Sites --- Hormones --- Ligands --- Chemistry --- Life Sciences --- Biochemistry --- Biology --- Biophysics --- Genetics --- Immunology --- Récepteurs cellulaires --- Périodiques --- MDBIOCHE MDCYTOLO MDPHYSIO --- Receptors, Cell Surface --- Receptors, Drug --- Signal Transduction --- Cell Signaling --- Human medicine --- Cell Surface Receptor --- Receptor, Cell Surface --- Surface Receptor, Cell

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