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The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field.    The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.  .

Histology. Cytology --- Physiology of the respiratory system --- Human physiology --- Pathology of the respiratory system --- farmacologie --- toxicologie --- pneumologie --- biotechnologie --- fysiologie --- cytologie --- moleculaire biologie

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Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Immunology. Immunopathology --- Human physiology --- Pathological biochemistry --- Pathology of the respiratory system --- Human medicine --- immunologie --- medische biochemie --- biomedische wetenschappen --- toxicologie --- fysiologie

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This book comprehensively covers many aspects of green mine, including the basic situation of green mines, mine facilities, extraction management, ecological environment, scientific and technological innovation, standardized management, environmental protection inspectors, and special tools in response to the needs of green mine construction, assessment, and management. It is highly informative with valuable techniques and tools providing insights both for scholars and practitioners working in green mine field.

Rocks. Minerals --- Relation between energy and economics --- Environmental protection. Environmental technology --- energiebeheer (technologie) --- mineralogie --- energiemanagement (economie) --- energiebeleid --- energie-economie --- milieubeleid

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Mathematics --- Computer science --- Programming --- Computer architecture. Operating systems --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- toegepaste informatica --- computers --- informatica --- externe fixatie (geneeskunde --- programmeren (informatica) --- wiskunde --- AI (artificiële intelligentie) --- computernetwerken --- computerkunde

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This book aims to discuss the core and underlying principles and analysis of the different constraint handling approaches. The main emphasis of the book is on providing an enriched literature on mathematical modelling of the test as well as real-world problems with constraints, and further development of generalized constraint handling techniques. These techniques may be incorporated in suitable metaheuristics providing a solid optimized solution to the problems and applications being addressed. The book comprises original contributions with an aim to develop and discuss generalized constraint handling approaches/techniques for the metaheuristics and/or the applications being addressed. A variety of novel as well as modified and hybridized techniques have been discussed in the book. The conceptual as well as the mathematical level in all the chapters is well within the grasp of the scientists as well as the undergraduate and graduate students from the engineering and computer science streams. The reader is encouraged to have basic knowledge of probability and mathematical analysis and optimization. The book also provides critical review of the contemporary constraint handling approaches. The contributions of the book may further help to explore new avenues leading towards multidisciplinary research discussions. This book is a complete reference for engineers, scientists, and students studying/working in the optimization, artificial intelligence (AI), or computational intelligence arena. .

Mathematics --- Planning (firm) --- Artificial intelligence. Robotics. Simulation. Graphics --- neuronale netwerken --- fuzzy logic --- cybernetica --- mathematische modellen --- wiskunde --- KI (kunstmatige intelligentie) --- AI (artificiële intelligentie)