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Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin-signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.
Blood physiology. Circulatory physiology --- Semiology. Diagnosis. Symptomatology --- Pathology of the circulatory system --- Pathological endocrinology --- Human medicine --- geneeskunde --- endocrinologie --- cardiologie --- angiografie --- bloedsomloop --- lymfevaten
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The thoroughly updated second edition of this key textbook provides an authoritative discussion of cardiovascular disease for the practicing primary care clinician. It examines a variety of disease states with emphasis on risk factors, risk estimation, and established cardiac disease. The book also explores the co-morbid conditions that surround cardiovascular disease. It includes key points, algorithms, case studies, recommendations on evidence-based practice, and summary boxes. A key resource for the busy practitioner, the Second Edition of Comprehensive Cardiovascular Medicine in the Primary Care Setting is designed to give residents, fellows, and primary care physicians the skills to confidently perform assessments, initiate and maintain efficacious therapy, and know when a referral to a cardiologist is advisable.
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Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. With an estimated 80% of people with diabetes living in disadvantaged regions, and the key roles of lipoproteins in the pathogenesis of the chronic complications of diabetes, this volume will be relevant to many readers globally. It is our intention that the contents will advance knowledge of the readers who will use it to contribute to the reduction of the burden associated with altered lipoproteins in people with diabetes. The second edition of this book provides an updated and comprehensive review of the field. The book, which includes many tables and figures, is presented in three main sections: (i) Lipoprotein metabolism, qualitative changes and measurements; (ii) Lipoproteins and the complications of diabetes; and (iii) the treatment of lipoproteins in diabetes. Each chapter from the first edition has been updated, and new topics added. New topics include the links between glycemia and lipoproteins, the role of lipoproteins in ischemic stroke, the diagnosis and management of statin intolerance (which is thought to be more common in people with diabetes) and the use of PCSK9 inhibitors and fish oils in the management of lipoproteins in people with diabetes. This book is written by an international group of experts in the clinical, laboratory and research aspects of lipoproteins in diabetes. Lipoproteins in Diabetes Mellitus, 2nd Edition is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It is a must-have resource for primary care and specialist clinicians, clinical and basic science researchers and to trainees and students.
Blood physiology. Circulatory physiology --- Pathology of the circulatory system --- Pathological endocrinology --- endocrinologie --- cardiologie --- bloedsomloop --- lymfevaten
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Pharmacology. Therapy --- Pathology of the circulatory system --- Human medicine --- farmacologie --- geneeskunde --- toxicologie --- cardiologie --- huisartsen
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The second edition of this important book provides an up-to-date and comprehensive overview of clinical lipidology. Brand new chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease. The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard to their relationships to cardiovascular disease risk. The second edition contains more than thirty chapters covering such topics as the history of lipidology, lipoprotein metabolism and vascular biology, disorders of lipid metabolism, lifestyle/dietary and pharmacologic management for dyslipidemia, the management of dyslipidemia in certain subgroups (e.g., women, children, older patients) and lipid testing, as well as an examination of other biomarkers and testing procedures related to atherosclerosis and cardiovascular disease. The second edition of Therapeutic Lipidology is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
Pathology of the circulatory system --- Pathological endocrinology --- endocrinologie --- cardiologie
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This second edition provides an updated review on the current guidelines and practice standards for the clinical management of cardiovascular risk factors and prevention of cardiovascular diseases. Endorsed by the American Society for Preventive Cardiology, this practical textbook includes concise descriptions of major and newer risk factors, biomarkers, and best practices in the management and prevention of cardiovascular disease. The manual contains chapters on the epidemiology and risk factors for a variety of cardiovascular diseases including dyslipidemia, hypertension, diabetes, inflammation, and ischemic stroke. It examines behavioral factors, psychosocial stress, family history, nutrition, physical activity, smoking, alcohol use, and other sociocultural factors. In addition, the book discusses new imaging strategies in detection of cardiovascular disease, prevention of heart failure, atrial fibrillation, and peripheral arterial disease, and prevention for special populations. Throughout the manual, recommendations are based on guidelines endorsed by the American College of Cardiology, American Heart Association, and other major societies. The second edition of the ASPC Manual of Preventive Cardiology is an essential resource for physicians, medical students, residents, fellows, nurses, and other healthcare professionals and researchers in cardiology, primary care, health promotion and disease prevention, exercise physiology, and pharmacotherapy. .
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Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited. This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies. Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
Pathology of the circulatory system --- Human medicine --- geneeskunde --- cardiologie
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