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Digital
Immunotherapy for Gastrointestinal Cancer
Authors: ---
ISBN: 9783319430638 Year: 2017 Publisher: Cham Springer International Publishing

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Abstract

This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists. .


Multi
Data Monitoring Committees (DMCs) : Past, Present, and Future
Authors: ---
ISBN: 9783031287602 9783031287596 9783031287619 9783031287626 Year: 2023 Publisher: Cham Springer International Publishing

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This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial - by phase and therapeutic area.

Dreams and conflicts : the dictatorship of the viewer
Authors: --- --- ---
ISBN: 888491597X 9788884915979 Year: 2003

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Dreams and Conflicts - The Dictatorship of the Viewer is the exhibition catalogue of the 50th Venice Biennale. 250 artists, 63 foreign countries, Iran makes its debut, China comes, Mexico returns, technology takes a back seat, the great artists return, everything starts again from 1964. Dreams and Conflicts will not show political art, but rather a reflection on the politics of art. The viewer's experience before the exceptional nature of the artist's vision. Two contemporary subjects divided simply by a different look. The book is divided into the following sections: Z.O.U. Zone of Urgency: Zones where artistic creation has accelerated powerfully in the last ten years: China, Korea, Vietnam, Brazil, India; Individual Systems by Igor Zabel: Artists who use their own creative language to create a world of independent images as defence against the ideological aggression of society, particularly in East Europe. The Structure of Survival by Carlos Basualdo: The ways in which artists and architects have reacted against the effects of the financial recessions and politics of structural adaptation in developing countries. Utopia Station by Molly Nesbit, Hans Ulrich Obrist and Rirkrit Tiravanija: Contemporary art as workshop and historic non-space; Conflit by Catherine David: The work of artists in areas of conflict, such as the Middle East and Central Asia, who must constantly redefine the limits and freedom of their creative work; The Everyday Altered by Gabriel Orozco: The new generation of artists working in Mexico and Cuba. Clandestines by Francesco Bonami: A selection by 30 young artists; Fault Lines by Gilane Tawardos: In association with the Forum Africa Contemporary Art; Delays and Revolutions by Francesco Bonami and Daniel Birnbaum: contemporary art as constant conflict between the avant-garde and tradition, experiment and ideal form. The Zone constructed by A12, by Massimiliano Gioni: A temporary building to house the work of young Italian artists.

Keywords

Modern [styles and periods] --- Biënnale van Venetië --- Art --- anno 1900-1999 --- anno 2000-2099 --- 700.4 --- biënnale Venetië --- conceptuele kunst --- kunst --- beeldende kunst, musea - tentoonstellingen --- Biënnale van Venetië (50ste ; 2003) --- Kunsttentoonstellingen ; internationale --- 7.039 --- (069) --- Kunstgeschiedenis ; 2000 - 2050 --- (Musea. Collecties) --- Italië --- Biennale di Venezia --- twintigste eeuw --- schilderkunst --- beeldhouwkunst --- installaties --- video --- videokunst --- fotografie --- gruppo A12 --- Abergel Etty --- Ackermann Franz --- Althamer Pawel --- Ariatti Alessandra --- Assaël Micol --- Azizov Zeigam --- Barney Matthew --- Bayrle Thomas --- Bonk Ecke --- Brown Glenn --- Buzari Pash --- Cabrita Reis Pedro --- Cheang Shu Lea --- Cirugeda Santiago --- Cliostraat --- Dean Tacita --- Donnelly Trisha --- Durham Jimmie --- Eliasson Olafur --- Elmgreen & Dragset --- Dragset Ingar --- Elmgreen Michael --- Fischli Peter --- Weiss David --- Fischli & Weiss --- Framis Alicia --- Friedman Yona --- Genzken Isa --- Gillick Liam --- Golub Leon --- Graham Dan --- Hall Stuart --- Hirst Damien --- Höller Carsten --- Holmqvist Karl --- Hugonnier Marine --- Isozaki Arata --- Kabakov Ilya --- Kabakov Emilia --- Kippenberger Martin --- Koller Julius --- Kuri Gabriel --- Lertchaiprasert Kamin --- Linke Armin --- de Manincor Anna --- ZimmerFrei --- Murakami Takashi --- Pousttchi Bettina --- Rauschenberg Robert --- Rehberger Tobias --- Rosler Martha --- Ruscha Edward --- Sala Anri --- Smith Patti --- kunst en politiek --- migratie --- vluchtelingen --- Sone Yutaka --- Spero Nancy --- Starling Simon --- Tiravanija Rirkrit --- Tuttofuoco Patrick --- Uglycute --- U-theque --- van Hausswolff Carl Michael --- Vitamin Creative Space --- Yanhjiang Group --- Warhol Andy --- Weiner Lawrence --- Wyn Evans Cerith --- Fudong Yang --- utopia --- utopie --- globalisering --- andersglobalisme --- computerkunst --- nieuwe media --- 7.038 --- Exhibitions --- Modern [style or period] --- hedendaagse kunst --- Contemporary [style of art] --- Kunst --- modern [stijlen en perioden] --- Biennale de Venise --- Art et politique --- Art contemporain --- Manifestation artistique --- Venise


Digital
Crossed Products of C*-Algebras, Topological Dynamics, and Classification
Authors: --- --- --- ---
ISBN: 9783319708690 Year: 2018 Publisher: Cham Springer International Publishing, Imprint: Birkhäuser

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This book collects the notes of the lectures given at an Advanced Course on Dynamical Systems at the Centre de Recerca Matemàtica (CRM) in Barcelona. The notes consist of four series of lectures. The first one, given by Andrew Toms, presents the basic properties of the Cuntz semigroup and its role in the classification program of simple, nuclear, separable C*-algebras. The second series of lectures, delivered by N. Christopher Phillips, serves as an introduction to group actions on C*-algebras and their crossed products, with emphasis on the simple case and when the crossed products are classifiable. The third one, given by David Kerr, treats various developments related to measure-theoretic and topological aspects of crossed products, focusing on internal and external approximation concepts, both for groups and C*-algebras. Finally, the last series of lectures, delivered by Thierry Giordano, is devoted to the theory of topological orbit equivalence, with particular attention to the classification of minimal actions by finitely generated abelian groups on the Cantor set.

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