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This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

General biophysics --- Biotechnology --- biofysica --- biotechnologie --- COVID-19 (Disease) --- Cancer --- Neoplasms --- RNA --- COVID-19 --- Proteins --- Molecular aspects. --- therapy. --- genetics. --- RNA. --- COVID-19. --- Proteins.

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This book gathers a selection of peer-reviewed papers presented at the International Conference on Operations Research (OR 2021), which was hosted online by the University of Bern from August 31 to September 3, 2021, and was jointly organized by the Operations Research Societies of Switzerland (SVOR/ASRO), Germany (GOR e.V.), and Austria (ÖGOR). The respective papers discuss classical mathematical optimization, statistics and simulation techniques. These are complemented by computer science methods, and by tools for processing data, designing and implementing information systems. The book also examines recent advances in information technology, which allow massive volumes of data to be processed and enable real-time predictive and prescriptive business analytics to drive decisions and actions. Lastly, it presents a selection of problems that are modeled and treated while taking into account uncertainty, risk management, behavioral issues, etc.

Numerical methods of optimisation --- Operational research. Game theory --- Mathematical statistics --- Planning (firm) --- Production management --- Business management --- Computer. Automation --- automatisering --- management --- mathematische modellen --- productie --- econometrie --- wiskunde --- operationeel onderzoek

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This volume contains revised and extended research articles written by prominent researchers participating in the conference. Topics covered include engineering physics, communications systems, control theory, automation, engineering mathematics, scientific computing, industrial engineering, and industrial applications. IAENG Transactions on Engineering Technologies: Special Issue of the International MultiConference of Engineers and Computer Scientists 2012 offers the state of art of tremendous advances in engineering technologies and physical science and applications, and also serves as an excellent reference work for researchers and graduate students working with/on engineering technologies and physical science and applications.

Mathematics --- Applied physical engineering --- Engineering sciences. Technology --- Computer architecture. Operating systems --- Artificial intelligence. Robotics. Simulation. Graphics --- neuronale netwerken --- fuzzy logic --- cybernetica --- analyse (wiskunde) --- mechatronica --- industriële robots --- automatisering --- economie --- wiskunde --- KI (kunstmatige intelligentie) --- ingenieurswetenschappen --- computernetwerken --- AI (artificiële intelligentie)

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This volume contains revised and extended research articles written by prominent researchers participating in the international conference on Advances in Engineering Technologies and Physical Science was held in Hong Kong, 13-15 March, 2013. Topics covered include engineering physics, engineering mathematics, scientific computing, control theory, automation, artificial intelligence, electrical engineering, and industrial applications. The book offers the state of art of tremendous advances in engineering technologies and physical science and applications, and also serves as an excellent reference work for researchers and graduate students working with/on engineering technologies and physical science and applications.

Mathematics --- Mathematical physics --- Applied physical engineering --- Engineering sciences. Technology --- Planning (firm) --- Artificial intelligence. Robotics. Simulation. Graphics --- neuronale netwerken --- fuzzy logic --- cybernetica --- analyse (wiskunde) --- mechatronica --- theoretische fysica --- industriële robots --- automatisering --- economie --- mathematische modellen --- wiskunde --- KI (kunstmatige intelligentie) --- ingenieurswetenschappen --- AI (artificiële intelligentie)

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This volume comprises selected extended papers written by prominent researchers participating in the International MultiConference of Engineers and Computer Scientists 2015, Hong Kong, 18-20 March 2015. The conference served as a platform for discussion of frontier topics in theoretical and applied engineering and computer science, and subjects covered include communications systems, control theory and automation, bioinformatics, artificial intelligence, data mining, engineering mathematics, scientific computing, engineering physics, electrical engineering, and industrial applications. The book describes the state-of-the-art in engineering technologies and computer science and its applications, and will serve as an excellent reference for industrial and academic researchers and graduate students working in these fields.

Mathematics --- Mathematical physics --- Physics --- Electrical engineering --- Applied physical engineering --- Engineering sciences. Technology --- Planning (firm) --- Mass communications --- Programming --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- analyse (wiskunde) --- toegepaste wiskunde --- theoretische fysica --- bio-informatica --- automatisering --- economie --- mathematische modellen --- computerbesturingssystemen --- programmeren (informatica) --- wiskunde --- software engineering --- ingenieurswetenschappen --- fysica --- elektrotechniek --- robots --- communicatietechnologie