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Homology - a similar trait shared by different species and derived from common ancestry, such as a seal's fin and a bird's wing - is one of the most fundamental yet challenging concepts in evolutionary biology. This ground-breaking book provides the first mechanistically based theory of what homology is and how it arises in evolution. Günter Wagner, one of the preeminent researchers in the field, argues that homology, or character identity, can be explained through the historical continuity of character identity networks - that is, the gene regulatory networks that enable differential gene expression. He shows how character identity is independent of the form and function of the character itself because the same network can activate different effector genes and thus control the development of different shapes, sizes, and qualities of the character. Demonstrating how this theoretical model can provide a foundation for understanding the evolutionary origin of novel characters, Wagner applies it to the origin and evolution of specific systems, such as cell types; skin, hair, and feathers; limbs and digits; and flowers. -- from dust jacket.

Pure sciences. Natural sciences (general) --- Developmental genetics --- Evolution (Biology) --- Genetic regulation --- Molecular evolution --- Evolution, Molecular --- Sequence Homology --- Gene Expression Regulation