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'Cell Surface GRP78, a New Paradigm in Signal Transduction Biology' presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.
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The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such
Autoimmunity. --- Tumor necrosis factor --- Autoimmune diseases --- Cellular signal transduction. --- Receptors. --- Etiology.
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This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
Histology. Cytology --- Immunology. Immunopathology --- immunologie --- cytologie --- histologie --- Immunology. --- Immune system. --- Cellular signal transduction. --- Cytology. --- Autoimmunity. --- Immunospecificity. --- Immune Cell Signalling. --- Cell Biology. --- Adaptive Immunity. --- Fosfatidilinositols --- Immunitat cel·lular
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A volume in the Handbook of Clinical Neurophysiology series on the visual system. The ultimate reference source for clinical neurophysiologists on disorders of visual processing. Volume in a prestigious series published in association with the International Federation of clinical Neurophysiology. International contributor list drawn from around the world. Discusses anatomy and physiology, techniques used in clinical neurophysiology, disorders of peripheral visual processing and disorders of central visual processing.
Eye Diseases --- Diagnostic Techniques and Procedures --- Light Signal Transduction --- Afferent Pathways --- Sensation Disorders --- Sensation --- Neurobehavioral Manifestations --- Ocular Physiological Processes --- Signal Transduction --- Diagnosis --- Neurologic Manifestations --- Behavior and Behavior Mechanisms --- Ocular Physiological Phenomena --- Psychophysiology --- Neural Pathways --- Nervous System Physiological Processes --- Diseases --- Biochemical Processes --- Nervous System --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Signs and Symptoms --- Phenomena and Processes --- Psychological Phenomena and Processes --- Nervous System Diseases --- Psychiatry and Psychology --- Cell Physiological Processes --- Nervous System Physiological Phenomena --- Cell Physiological Phenomena --- Chemical Processes --- Pathological Conditions, Signs and Symptoms --- Musculoskeletal and Neural Physiological Phenomena --- Anatomy --- Biochemical Phenomena --- Chemical Phenomena --- Perceptual Disorders --- Vision, Ocular --- Visual Pathways --- Diagnostic Techniques, Ophthalmological --- Vision Disorders --- Diagnostic Techniques, Neurological
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