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Genetic Diseases of the Kidney provides expert insight into the role of genetic abnormalities in the pathogenesis of deranged kidney function and kidney disease. The principles of mammalian genetics are first elaborated, with special consideration given to the application of genetic analysis to clinical syndromes and diseases. Specific renal diseases are next analyzed. Monogenic disorders confined to the kidney - diseases of nephron function, renal development, and renal neoplasia - are then treated in detail in some 30 chapters. Both specific diseases - Fanconi syndrome, Bartter's

Kidneys --- Diseases --- Genetic aspects.

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The untold story of how hereditary data in mental hospitals gave rise to the science of human heredityIn the early 1800s, a century before there was any concept of the gene, physicians in insane asylums began to record causes of madness in their admission books. Almost from the beginning, they pointed to heredity as the most important of these causes. As doctors and state officials steadily lost faith in the capacity of asylum care to stem the terrible increase of insanity, they began emphasizing the need to curb the reproduction of the insane. They became obsessed with identifying weak or tainted families and anticipating the outcomes of their marriages. Genetics in the Madhouse is the untold story of how the collection and sorting of hereditary data in mental hospitals, schools for "feebleminded" children, and prisons gave rise to a new science of human heredity.In this compelling book, Theodore Porter draws on untapped archival evidence from across Europe and North America to bring to light the hidden history behind modern genetics. He looks at the institutional use of pedigree charts, censuses of mental illness, medical-social surveys, and other data techniques--innovative quantitative practices that were worked out in the madhouse long before the manipulation of DNA became possible in the lab. Porter argues that asylum doctors developed many of the ideologies and methods of what would come to be known as eugenics, and deepens our appreciation of the moral issues at stake in data work conducted on the border of subjectivity and science.A bold rethinking of asylum work, Genetics in the Madhouse shows how heredity was a human science as well as a medical and biological one.

History --- Mental illness --- Genetic aspects.

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Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detail novel molecular classifications of tumors, and identify diagnostic and prognostic biomarkers for various types of cancers, including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice.

Genetics --- Cancer --- Genetic aspects. --- Molecular aspects.

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Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment.ïÅư This volumes offer a unique evaluation of signature differences in of childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments.ïÅư Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

Cancer --- Epigenetics. --- Neoplasms --- Epigenesis, Genetic. --- Genetic aspects. --- genetics.

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A Practical Guide to Human Cancer Genetics, 4th edition, is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. This fully updated new edition covers risk analysis and genetic counseling for individuals with a family history of cancer, and includes a discussion of predictive testing and the organisation of the cancer genetics service. There is also information about the genes causing Mendelian cancer predisposing conditions and their mechanisms of action. This book is an invaluable reference source for students, general practitioners, geneticists and specialist clinicians in all disciplines.

Oncology. Neoplasms --- Human genetics --- medische genetica --- genetica --- oncologie --- Cancer --- Genetic aspects.