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Mutagenicity Tests. --- Kanker --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Cancer --- Carcinogenicity testing. --- Carcinogenicity testing --- Mutagenicity Tests --- Carcinogenesis --- Carcinogenic activity testing --- Carcinogens --- Testing for carcinogenicity --- Chronic toxicity testing --- Oncology, Experimental --- Testing
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Data Interpretation, Statistical. --- Mutagenicity Tests. --- Mutagens --- Mutagenicity testing --- -Mutagen testing --- Mutagenesis --- Chronic toxicity testing --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- toxicity. --- Statistical methods --- Testing --- Statistical methods. --- -toxicity. --- Data Interpretation, Statistical --- Mutagenicity Tests --- Mutagen testing --- toxicity
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Personalised medicine is the next step in healthcare, especially when applied to genetically diverse diseases such as cancers. Naturally, a host of methods need to evolve alongside this, in order to allow the practice and implementation of individual treatment regimens. One of the major tasks for the development of personalised treatment of cancer is the identification and validation of a comprehensive, robust, and reliable panel of biomarkers that guide the clinicians to provide the best treatment to patients. This is indeed important with regards to radiotherapy; not only do biomarkers allow for the assessment of treatability, tumour response, and the radiosensitivity of healthy tissue of the treated patient. Furthermore, biomarkers should allow for the evaluation of the risks of developing adverse late effects as a result of radiotherapy such as second cancers and non-cancer effects, for example cardiovascular injury and cataract formation. Knowledge of all of these factors would allow for the development of a tailored radiation therapy regime. This Special Issue of the Journal of Personalised Medicine covers the topic of Radiation Response Biomarkers in the context of individualised cancer treatments, and offers an insight into some of the further evolution of radiation response biomarkers, their usefulness in guiding clinicians, and their application in radiation therapy.
Medicine --- carbon-ion radiotherapy --- head-and-neck tumors --- squamous cell carcinoma --- radiosensitivity --- relative biological effectiveness --- lung cancer --- radiotherapy --- radiotherapy monitoring --- radiation-induced lung injury --- RILI --- pneumonitis --- radiation-induced lung fibrosis --- RILF --- circulating biomarkers --- microRNA --- micronuclei --- uterine cervical cancer --- cGAS --- STING --- abscopal effect --- immunotherapy --- PBMCS --- micronucleus assay --- biological dosimetry --- human blood --- genotoxicity tests --- ionizing radiation --- biomarkers --- dicentric assay --- gamma H2AX foci assay --- health surveillance analyses --- clonogenic assays --- methods --- plating --- cancer --- radiation --- head and neck cancer --- exosomes --- serum --- metabolomics --- GC/MS --- biodosimetry --- chromosome aberrations --- normal tissue toxicity --- predictive tests --- normal tissue --- biomarker --- protein --- immune infiltrate --- stroma --- tumour microenvironment --- proteomics --- telomeres --- chromosomal instability --- inversions --- prostate cancer --- IMRT --- machine learning --- individual radiosensitivity --- late effects --- personalized medicine --- liquid biopsy --- circulating tumour cells --- extracellular vesicles --- microRNAs --- immune system --- inflammation --- carbon-ion radiotherapy --- head-and-neck tumors --- squamous cell carcinoma --- radiosensitivity --- relative biological effectiveness --- lung cancer --- radiotherapy --- radiotherapy monitoring --- radiation-induced lung injury --- RILI --- pneumonitis --- radiation-induced lung fibrosis --- RILF --- circulating biomarkers --- microRNA --- micronuclei --- uterine cervical cancer --- cGAS --- STING --- abscopal effect --- immunotherapy --- PBMCS --- micronucleus assay --- biological dosimetry --- human blood --- genotoxicity tests --- ionizing radiation --- biomarkers --- dicentric assay --- gamma H2AX foci assay --- health surveillance analyses --- clonogenic assays --- methods --- plating --- cancer --- radiation --- head and neck cancer --- exosomes --- serum --- metabolomics --- GC/MS --- biodosimetry --- chromosome aberrations --- normal tissue toxicity --- predictive tests --- normal tissue --- biomarker --- protein --- immune infiltrate --- stroma --- tumour microenvironment --- proteomics --- telomeres --- chromosomal instability --- inversions --- prostate cancer --- IMRT --- machine learning --- individual radiosensitivity --- late effects --- personalized medicine --- liquid biopsy --- circulating tumour cells --- extracellular vesicles --- microRNAs --- immune system --- inflammation
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Abnormalities, Drug-Induced. --- Embryonic and Fetal Development --- Mutagenicity Tests. --- Reproduction --- Teratogens --- Prenatal Exposure Delayed Effects. --- Toxicology. --- Developmental toxicology --- Reproductive toxicology --- Toxicology --- Toxicology, Developmental --- Developmental biology --- Teratogenesis --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Pharmacogenetics --- Late Effects, Prenatal Exposure --- Delayed Effects, Prenatal Exposure --- Maternal Exposure --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- drug effects. --- toxicity. --- Developmental toxicology. --- Reproductive toxicology. --- Abnormalities, Drug-Induced --- Mutagenicity Tests --- Prenatal Exposure Delayed Effects --- Drug-Induced Abnormalities --- Abnormalities, Drug Induced --- Abnormality, Drug-Induced --- Drug Induced Abnormalities --- Drug-Induced Abnormality --- Congenital Abnormalities --- Maternal-Fetal Exchange --- drug effects --- toxicity --- chemically induced
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Personalised medicine is the next step in healthcare, especially when applied to genetically diverse diseases such as cancers. Naturally, a host of methods need to evolve alongside this, in order to allow the practice and implementation of individual treatment regimens. One of the major tasks for the development of personalised treatment of cancer is the identification and validation of a comprehensive, robust, and reliable panel of biomarkers that guide the clinicians to provide the best treatment to patients. This is indeed important with regards to radiotherapy; not only do biomarkers allow for the assessment of treatability, tumour response, and the radiosensitivity of healthy tissue of the treated patient. Furthermore, biomarkers should allow for the evaluation of the risks of developing adverse late effects as a result of radiotherapy such as second cancers and non-cancer effects, for example cardiovascular injury and cataract formation. Knowledge of all of these factors would allow for the development of a tailored radiation therapy regime. This Special Issue of the Journal of Personalised Medicine covers the topic of Radiation Response Biomarkers in the context of individualised cancer treatments, and offers an insight into some of the further evolution of radiation response biomarkers, their usefulness in guiding clinicians, and their application in radiation therapy.
carbon-ion radiotherapy --- head-and-neck tumors --- squamous cell carcinoma --- radiosensitivity --- relative biological effectiveness --- lung cancer --- radiotherapy --- radiotherapy monitoring --- radiation-induced lung injury --- RILI --- pneumonitis --- radiation-induced lung fibrosis --- RILF --- circulating biomarkers --- microRNA --- micronuclei --- uterine cervical cancer --- cGAS --- STING --- abscopal effect --- immunotherapy --- PBMCS --- micronucleus assay --- biological dosimetry --- human blood --- genotoxicity tests --- ionizing radiation --- biomarkers --- dicentric assay --- gamma H2AX foci assay --- health surveillance analyses --- clonogenic assays --- methods --- plating --- cancer --- radiation --- head and neck cancer --- exosomes --- serum --- metabolomics --- GC/MS --- biodosimetry --- chromosome aberrations --- normal tissue toxicity --- predictive tests --- normal tissue --- biomarker --- protein --- immune infiltrate --- stroma --- tumour microenvironment --- proteomics --- telomeres --- chromosomal instability --- inversions --- prostate cancer --- IMRT --- machine learning --- individual radiosensitivity --- late effects --- personalized medicine --- liquid biopsy --- circulating tumour cells --- extracellular vesicles --- microRNAs --- immune system --- inflammation --- n/a
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Actuarial mathematics --- Carcinogenicity testing --- Health risk assessment --- Cancérogénicité --- Risques pour la santé --- Decision making --- Prise de décision --- Evaluation --- Carcinogens --- Decision Making. --- Mutagenicity Tests. --- Risk. --- -Health risk assessment --- -Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Medicine, Preventive --- Public health --- Risk assessment --- Environmental health --- Carcinogenesis --- Carcinogenic activity testing --- Testing for carcinogenicity --- Chronic toxicity testing --- Oncology, Experimental --- Relative Risk --- Relative Risks --- Risk, Relative --- Risks --- Risks, Relative --- Risk Reduction Behavior --- Harm Reduction --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Decision Making, Shared --- Decision Makings, Shared --- Making, Shared Decision --- Makings, Shared Decision --- Shared Decision Making --- Shared Decision Makings --- Problem Solving --- toxicity. --- Testing --- -toxicity. --- Cancérogénicité --- Risques pour la santé --- Prise de décision --- Decision Making --- Mutagenicity Tests --- Risk --- Assessment, Health risk --- toxicity --- Citizen Science --- Incidence --- Credit Assignment --- Assignment, Credit --- Assignments, Credit --- Credit Assignments
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Carcinogenese -- Testen --- Carcinogenese -- Tests --- Carcinogenicity testing --- Determination de la mutagenicite --- Mutagenicity testing --- Mutageniteitsbepaling --- Carcinogens --- Mutagens --- Mutagenicity Tests --- Evaluation Studies as Topic --- analysis --- Biological Assay. --- Carcinogenicity Tests. --- Evaluation Studies as Topic. --- Mutagenicity Tests. --- 576.385.5 --- .001.4 --- $?$91/02 --- Kanker --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Critique --- Evaluation --- Evaluation Indexes --- Evaluation Methodology --- Evaluation Report --- Evaluation Research --- Methodology, Evaluation --- Pre-Post Tests --- Qualitative Evaluation --- Quantitative Evaluation --- Theoretical Effectiveness --- Use-Effectiveness --- Critiques --- Effectiveness, Theoretical --- Evaluation Methodologies --- Evaluation Reports --- Evaluation, Qualitative --- Evaluation, Quantitative --- Evaluations --- Evaluations, Qualitative --- Evaluations, Quantitative --- Indexes, Evaluation --- Methodologies, Evaluation --- Pre Post Tests --- Pre-Post Test --- Qualitative Evaluations --- Quantitative Evaluations --- Report, Evaluation --- Reports, Evaluation --- Research, Evaluation --- Test, Pre-Post --- Tests, Pre-Post --- Use Effectiveness --- Carcinogen Tests --- Carcinogenesis Tests --- Carcinogenic Activity Tests --- Carcinogenic Potency Tests --- Tumorigenicity Tests --- Carcinogen Test --- Carcinogenesis Test --- Carcinogenic Activity Test --- Carcinogenic Potency Test --- Carcinogenicity Test --- Potency Test, Carcinogenic --- Potency Tests, Carcinogenic --- Test, Carcinogen --- Test, Carcinogenesis --- Test, Carcinogenic Activity --- Test, Carcinogenic Potency --- Test, Carcinogenicity --- Test, Tumorigenicity --- Tests, Carcinogen --- Tests, Carcinogenesis --- Tests, Carcinogenic Activity --- Tests, Carcinogenic Potency --- Tests, Carcinogenicity --- Tests, Tumorigenicity --- Tumorigenicity Test --- Assay, Biological --- Assays, Biological --- Biologic Assay --- Biologic Assays --- Bioassay --- Assay, Biologic --- Assays, Biologic --- Bioassays --- Biological Assays --- Cancer --- Biological Assay
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Carcinogenicity testing --- Carcinogenesis --- Abnormalities, Human --- Carcinogens --- Cancérogénicité --- Cancérogenèse --- Cancérogènes --- Etiology --- Carcinogenicity Tests. --- Mutagenicity Tests. --- Risk Assessment. --- Carcinogenic activity testing --- Testing for carcinogenicity --- Chronic toxicity testing --- Oncology, Experimental --- Risks and Benefits --- Assessment, Risk --- Benefit-Risk Assessment --- Risk-Benefit Assessment --- Assessment, Benefit-Risk --- Assessment, Risk-Benefit --- Assessments, Benefit-Risk --- Assessments, Risk --- Assessments, Risk-Benefit --- Benefit Risk Assessment --- Benefit-Risk Assessments --- Benefits and Risks --- Risk Assessments --- Risk Benefit Assessment --- Risk-Benefit Assessments --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Carcinogen Tests --- Carcinogenesis Tests --- Carcinogenic Activity Tests --- Carcinogenic Potency Tests --- Tumorigenicity Tests --- Carcinogen Test --- Carcinogenesis Test --- Carcinogenic Activity Test --- Carcinogenic Potency Test --- Carcinogenicity Test --- Potency Test, Carcinogenic --- Potency Tests, Carcinogenic --- Test, Carcinogen --- Test, Carcinogenesis --- Test, Carcinogenic Activity --- Test, Carcinogenic Potency --- Test, Carcinogenicity --- Test, Tumorigenicity --- Tests, Carcinogen --- Tests, Carcinogenesis --- Tests, Carcinogenic Activity --- Tests, Carcinogenic Potency --- Tests, Carcinogenicity --- Tests, Tumorigenicity --- Tumorigenicity Test --- Mutagenicity Tests --- Testing --- Heatlh Risk Assessment --- Assessment, Heatlh Risk --- Assessments, Heatlh Risk --- Heatlh Risk Assessments --- Risk Assessment, Heatlh --- Risk Assessments, Heatlh --- Cancérogénicité --- Cancérogenèse --- Cancérogènes --- Risk Assessment --- Health Risk Assessment --- Assessment, Health Risk --- Assessments, Health Risk --- Health Risk Assessments --- Risk Assessment, Health --- Risk Assessments, Health --- Risk Analysis --- Analysis, Risk --- Risk Analyses
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