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Xenobiotics --- Metabolism --- Nutritional aspects --- Congresses --- Pharmacological Processes --- Chemicals and Drugs --- Noxae --- Food and Beverages --- Specialty Uses of Chemicals --- Physiological Processes --- Metabolic Phenomena --- Pharmacological Phenomena --- Technology, Industry, Agriculture --- Toxic Actions --- Chemical Actions and Uses --- Physiological Phenomena --- Phenomena and Processes --- Pharmaceutical Preparations --- Poisons --- Biotransformation --- Food --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Xenobiotics - Metabolism - Nutritional aspects - Congresses

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"Lecture Notes: Clinical Pharmacology and Therapeutics provides a readable overview of all the key prescribing topics needed for medical finals and beyond. Detailed coverage and discussion of pharmacology in a clinical context combined with an accessible style mean readers can rely on the title to improve and test their understanding of pharmacological principles and reasoning throughout their time on rotation and on into foundation year. Now fully updated to include key information on Prescribing Safety Assessment, other key features of this important text include: Clinical scenarios to root each chapter firmly in a real-life setting; Prescribing points flagging up important issues of clinical relevance; Sections on drugs you may need in a hurry, prescribing and its pitfalls, and paediatric prescribing"--

Pharmacological Phenomena --- Pharmacology, Clinical --- Drug Therapy --- Phénomènes pharmacologiques et toxicologiques --- Pharmacologie clinique --- Traitement médicamenteux --- methods --- méthodes --- Chimiothérapie --- Méthodes. --- Clinical Pharmacology --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Pharmacological Phenomena. --- methods.

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I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized because of research at the chem- try–biology interface. I am hoping that this comprehensive volume on recent advances in bioactivation research will stimulate pharmacologists, medicinal chemists, phar- ceutical scientists, and graduate students in these fields and related areas to consider and use bioactivation research when they explore and chart new frontiers in drug design and drug development and when they consider ways to reduce the side effects of existing drugs by making prodrugs. As for the toxicologists and environmental health scientists, I hope this volume will help them generate the knowledge needed to understand better mechanisms of toxicity to improve human risk assessments and intervention methods after occupational or environmental exposure to various hazardous chemicals. Adnan A. Elfarra, Ph. D. vii Part I General Concepts and Basic Mechanisms 1 Metabolic Concerns in Drug Design Jeffrey P. Jones Department of Chemistry, Washington State University, Pullman, WA 99164, USA e-mail: jpj@wsu. edu Keywords: Cytochrome P450 Aldehyde Oxidase Drug–Drug Interactions Mechanism-based Virtual Screening ADMET Regioselectivity 1. 1. Introduction Due to recent technological innovations, such as genomics, combinatorial chemistry, and high-throughput screening, the identification of disease targets and of compounds that are active against these targets (‘‘leads’’) can now be carried out efficiently.

Biomedicine. --- Pharmacology/Toxicology. --- Immunology. --- Medicine. --- Toxicology. --- Médecine --- Immunologie --- Toxicologie --- Biotransformation (Metabolism). --- Biotransformation. --- Drug activation. --- Biotransformation (Metabolism) --- Drug activation --- Pharmacological Processes --- Metabolism --- Metabolic Phenomena --- Pharmacological Phenomena --- Physiological Processes --- Physiological Phenomena --- Phenomena and Processes --- Biotransformation --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Activation of drugs --- Drugs --- Activation --- Pharmacology. --- Pharmacology --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Physiological effect

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The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation.  The third edition features five new chapters that cover material not addressed in previous editions.  These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic,  macrolide, azalide and ketolide agents.  A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development.  These chapters address material that cannot be retrieved easily in the medical literature.  The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references.  The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions.  Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation.  This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features ·         Definitive reference source of up-to-date information on antimicrobial drug interactions ·         Informative tables on the degree of interaction for specific antimicrobial agents ·         In-depth discussion of mechanisms and potential mechanistic pathways of interaction ·         New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents ·         New chapter on probe-cocktail studies as a research tool to study drug-drug interactions ·         Inclusion of new antimicrobial agents and their associated drug interactions ·         First rate chapters on study design and analysis, and drug-food interactions ·         A fresh perspective on drug-cytokine interactions ·         Authoritative chapter on regulatory considerationsof drug interactions during drug development ·         Inclusion of new antimicrobial agents and their associated drug interactions.

Anti-infective agents -- Side effects. --- Drug interactions. --- Anti-infective agents --- Drug interactions --- Pharmacological Processes --- Therapeutic Uses --- Physiological Processes --- Pharmacological Phenomena --- Pharmacologic Actions --- Chemical Actions and Uses --- Physiological Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Anti-Infective Agents --- Drug Interactions --- Health & Biological Sciences --- Medicine --- Pharmacy, Therapeutics, & Pharmacology --- Infectious Diseases --- Side effects --- Side effects. --- Interactions, Drug --- Pharmacy. --- Medicine. --- Pharmaceutical technology. --- Infectious diseases. --- Medicine & Public Health. --- Infectious Diseases. --- Pharmaceutical Sciences/Technology. --- Drugs --- Emerging infectious diseases. --- Chemistry --- Materia medica --- Pharmacology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology

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Geriatric pharmacology --- Drug interactions --- Pharmacokinetics --- Older African Americans --- Adult --- African Continental Ancestry Group --- Kinetics --- Pharmacological Processes --- Pharmacological Phenomena --- Therapeutics --- Ethnic Groups --- Phenomena and Processes --- Biochemical Phenomena --- Population Groups --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Age Groups --- Physiological Processes --- Continental Population Groups --- Persons --- Chemical Phenomena --- Named Groups --- Drug Therapy --- African Americans --- Drug Interactions --- Aged --- Medicine --- Health & Biological Sciences --- Geriatrics --- Age factors --- Medical care --- Drug use --- Geriatric pharmacology. --- Drug interactions. --- Age factors. --- Medical care. --- Drug use. --- African American aged --- African American older people --- Afro-American aged --- Older people, African American --- Age factors in pharmacokinetics --- Interactions, Drug --- Older people --- Aging --- Drugs --- Pharmacology --- Side effects