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This fully updated edition provides the most recent advances in cancer cell signaling knowledge combined with some discussion of the current challenges and prospects in cancer therapy. Beginning with an important section on cancer resistance, the main obstacle to effective cancer therapy, the book continues with chapters exploring state-of-the-art methods in epigenetic control of cancer, metastasis promotion, as well as a variety of new technologies in the study of cancer. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Cancer Cell Signaling: Methods and Protocols, Third Edition serves as an ideal guide to researchers seeking to overcome the challenges in the vital field of cancer cell signaling.

Cèl·lules canceroses --- Cèl·lules --- Patologia cel·lular --- Metàstasi --- Càncer --- Biomechanics. --- Cancer. --- Cancer Biology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Biological mechanics --- Mechanical properties of biological structures --- Biophysics --- Mechanics --- Contractility (Biology)

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This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Pathology. --- Pharmacology/Toxicology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Tumors --- Xoc --- Anatomia patològica --- Diagnòstic

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This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems and pitfalls.

Pathology. --- Hematology. --- Oncology  . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Medul·la òssia --- Biòpsia --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Cirurgia operatòria --- Biòpsia per aspiració --- Sistema immunitari --- Trastorns mieloproliferatius

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This new textbook on bacterial physiology is aimed at senior level students pursuing a one-semester course in the biology or microbiology curriculum. The text takes a balanced view of prokaryotic physiology, discussing both bioenergetics and bacterial metabolism in a way that establishes general principles and concepts and emphasizes throughout the information gained from model systems. The book also covers some experimental design issues, giving students an appreciation of the practical aspects and consequences of bacterial metabolism. It also stimulates students’ interests in future developments in the field by including discussions by five world-famous bacterial physiologists about future developments in the field.

Prokaryotes. --- Monera --- Procaryotae --- Procaryotes --- Prokaryonta --- Prokaryotae --- Prokaryotic protists --- Microorganisms --- Bacteriology. --- Microbiology. --- Biochemistry. --- Cytology. --- Biochemistry, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Microbial biology --- Microbiology --- Composition --- Cell biology. --- Cèl·lules --- Fisiologia cel·lular --- Fisiologia --- Motilitat cel·lular --- Biologia --- Reproducció --- Astròcits --- Blastoderma --- Cèl·lules eucariotes --- Cèl·lules canceroses --- Cèl·lules epitelials --- Cèl·lules germinals --- Cèl·lules hepàtiques --- Cèl·lules i teixits vegetals --- Cèl·lules mare --- Cèl·lules musculars --- Cèl·lules sanguínies --- Citoplasma --- Cromatina --- Fecundació --- Fibroblasts --- Histologia --- Irritabilitat --- Mort cel·lular --- Neurones --- Neurones motores --- Patologia cel·lular --- Protoplasts --- Protozous --- Ou (Biologia) --- Ultraestructura (Biologia) --- Citologia --- Clonatge --- Embriologia --- Protoplasma --- Regeneració (Biologia)

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This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy. The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems. .

Pathology. --- Oncology  . --- Surgery. --- Oncology. --- Surgery, Primitive --- Medicine --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Breast Neoplasms --- pathology. --- Breast --- Diagnosis. --- Mama --- Càncer de mama --- Biòpsia --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Cirurgia operatòria --- Biòpsia per aspiració --- Càncer de pit --- Càncer --- Malalties de la mama --- Càncer ginecològic --- Mames --- Mamella --- Mamelles --- Pit --- Pits --- Sines --- Glàndules mamàries --- Alletament --- Llet materna