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Our study clearly establishes that the one-third partial hepatectomy is of particular interest in the study of the regenerative response, as In contrast to the two-thirds partial hepatectomy, it can easily be amplified by various factors.
In the first part, infusion of Diprivan (Propofol) increases the DNA synthesis in 10% partial hepatectomy from control value 13.2+/-1.8 to 54.5+/-7.7 (P<0.01),in one-third partial hepatectomy from 41.5+/-3.1 to 102.7+/-11.5 (P<0.001), in sham operation from 7.2+/-1.7 to 23.1+/-3.4 (P<0.01) but not after a two-thirds partial hepatectomy. Infusion in Intralipid emulsion alone also increases the DNA synthesis in 10% partial hepatectomy from 13.2+/-1.8 to 24.3+/-2.0 (P<0.01), in one-third partial hepatectomy from 7.2+/-1.7 to 20.4+/-4.2 (P<0.5) but not in two-thirds partial hepatectomy.
In the second part, a stimulatory effect of HGF administration on the DNA synthesis after a one-third partial hepatectomy, is obtained by two injections, immediately and at 12 hours (from control value 41+/-3.1 to 143+/-27.2 (P<0.001), by continuous infusion during 24 hours (to 109+/-20 P<0.01) or by a single injection at the 10th hour (to 105+/-19.5 O<0.01). By contrast, the administration immediately after the one-third partial hepatectomy seems much less efficient (65+/-18.8).
In the third part, the conversion of one-third into a two-third partial hepatectomy obtains a 24-jour response identical to the one after classic two-thirds partial hepatectomy (315+/-24 versus 333+/-18). By contrast, when the conversion is delayed at 14 hours, this response is markedly reduced (50+/-13).
These results suggest that the one-third partial hepatectomy is an interesting model which is more sensitive and it is susceptible to be modified by various factors such a Diprivan, Intralipid. The magnitude of the regenerative response to a one-third partial hepatectomy is easily modified at around the 10th hour by the administration of HGF or by the further reduction of the liver mass.

Hepatectomy --- Propofol --- Hepatocyte Growth Factor --- Liver Regeneration

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HEPATITIS, VIRAL, HUMAN --- LIVER DISEASES --- CHRONIC DISEASE --- LIVER REGENERATION --- HEPATITIS VIRUSES --- ETHANOL --- ADVERSE EFFECTS

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Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of research disciplines. This book brings together current fin

Liver. --- Liver Neoplasms. --- Liver Regeneration. --- Liver--Cancer. Liver--Regeneration. Pathology, Molecular. Liver--Molecular aspects. Liver Regeneration. Liver Neoplasms--genetics. --- Pathology, Molecular. --- Liver --- Pathology, Molecular --- Liver Regeneration --- Genetics --- Liver Neoplasms --- Biology --- Digestive System Neoplasms --- Liver Diseases --- Regeneration --- Digestive System Processes --- Digestive System Diseases --- Digestive System Physiological Phenomena --- Neoplasms by Site --- Biological Processes --- Biological Science Disciplines --- Neoplasms --- Biological Phenomena --- Diseases --- Digestive System and Oral Physiological Phenomena --- Natural Science Disciplines --- Phenomena and Processes --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Molecular aspects --- Cancer. --- Molecular aspects. --- Regeneration. --- Molecular pathology --- Hepatic regeneration --- Hepatocellular carcinoma --- Molecular biology --- Physiology, Pathological --- Abdomen --- Biliary tract

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Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease. By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management. Hundre

Liver -- Diseases. --- Liver -- Regeneration. --- Stem cells. --- Liver Regeneration --- Computer Simulation --- Stem Cells --- Cells --- Computing Methodologies --- Digestive System Processes --- Regeneration --- Information Science --- Anatomy --- Biological Processes --- Digestive System Physiological Phenomena --- Digestive System and Oral Physiological Phenomena --- Biological Phenomena --- Phenomena and Processes --- Liver --- Regeneration. --- Hepatic regeneration

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The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.

n/a --- tissue engineering --- regenerative medicine --- liver tissue bioengineering --- additive manufacturing --- copper toxicosis --- hepatobiliary stent --- reconditioning --- medical device --- liver regeneration --- Wilson Disease --- stem cells --- preclinical large animal model --- liver --- stem cell transplantation --- liver bioreactors --- personalized medicine --- direct printing --- hydrogel --- 3D structuring --- oxygen persufflation --- end-stage liver diseases --- 3D printing --- liver transplantation --- bioengineered organ --- randomized controlled trail