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The book 'Fused Pyranones: Multifaceted Building Blocks' delves into the chemistry of fused pyranones, particularly focusing on coumarins, chromones, and their derivatives. It serves as a comprehensive guide on the synthesis, chemical properties, and applications of these compounds in medicine and material science. The book highlights the significance of coumarins as versatile scaffolds for developing various heterocycles with wide-ranging applications, including medicinal drugs and industrial additives. It also outlines the advancements in synthetic methodologies, including catalytic and noncatalytic pathways. The book is intended for researchers and practitioners in the fields of chemistry and pharmaceutical sciences, offering an extensive review of the latest literature and research developments in the study of natural and synthetic coumarins and chromones.

Coumarins. --- Heterocyclic chemistry. --- Coumarins --- Heterocyclic chemistry

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The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists.

Anticoagulants (Medicine) --- Warfarin. --- Coumadin (Trademark) --- Coumarins --- Rodenticides --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Hematologic agents --- Blood --- Coagulation --- Pharmacology

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COUMARINS --- FLAVONOIDS --- ACETYLENES --- FRUIT DEVELOPMENT --- ETHNOBOTANY --- CHEMOTAXONOMY --- COMPARATIVE ANATOMY --- STOMATA --- CYTOGENETICS --- POLLEN --- FLOWERS --- TAXONOMY --- APIACEAE --- CHEMISTRY --- MORPHOLOGY --- BIOLOGY

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Resin glycosides are part of a very extensive family of secondary metabolites known as glycolipids or lipo-oligosaccharides and are constituents of complex resins (glycoresins) (1) unique to the morning glory family, Convolvulaceae (2). These active principles are responsible for the drastic purgative action of all the important Convolvulaceous species used in traditional medicine throughout the world since ancient times. Several commercial purgative crude drugs can be prepared from the roots of different species of Mexican morning glories. Their incorporation as therapeutic agents in Europe is an outstanding example of the assimilation of botanical drugs from the Americas as substitutes for traditional Old World remedies (3). Even though phytochemical investigations on the constituents of these drugs were initiated during the second half of the nineteenth century, the structure of their active ingredients still remains poorly known for some examples of these purgative roots. During the last two decades, the higher resolution c- abilities of modern analytical isolation techniques used in conjunction with pow- ful spectroscopic methods have facilitated the elucidation of the active principles of these relevant herbal products. This chapter describes the ethnobotanical information associated with the p- gative morning glory species and how traditional usages were instrumental in plant selection for chemical studies. The advantages and limitations of available analy- cal techniques for the isolation, puri?cation, and structure characterization of the individual constituents of these complex glycoconjugates are also discussed.

Anticoagulants (Medicine). --- Chemistry. --- Coumarins. --- Chemistry, Organic --- Chemistry --- Organic Chemistry --- Biochemistry --- Physical Sciences & Mathematics --- Chemistry, Organic. --- Organic chemistry --- Pharmacy. --- Organic chemistry. --- Organic Chemistry. --- Physical sciences --- Medicine --- Drugs --- Materia medica --- Pharmacology

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The main focus of this thematic collection is on the antimicrobial activity of essential oils and their combinations with conventional antimicrobial drugs, including the eradication of the existing biofilms, the explanation of the mechanisms underlying antimicrobial activity, and the preparation of stable formulations with essential oils, which boost their antimicrobial activity and provide greater stability. These issues are addressed in four research papers and three reviews, which present novel advances in the development and application of essential oils as antimicrobial agents via combinatorial and nano-based approaches.

Humanities --- Social interaction --- biofilm --- common juniper --- immortelle --- nontuberculous mycobacteria --- stainless steel --- Pistacia lentiscus var. Chia --- Chios mastic --- ageing --- chemical profile --- antibacterial --- antifungal --- α-pinene --- β-myrcene --- GC-MS --- HPTLC --- chitosan --- coating --- essential oils --- liposomes --- mechanism --- polyelectrolyte --- bacterial biofilm --- antimicrobial --- medical devices --- antimicrobial resistance --- combination therapy --- lavender essential oil --- nanoencapsulation --- synergy --- Apiaceae --- gas chromatography-mass spectrometry --- volatiles --- antimicrobial activity --- coumarins --- nanoemulsion --- Croton cajucara --- essential oil --- antifungal activity --- n/a