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Article
Regulation of fat synthesis and adipose differentiation
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Year: 1998

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Article
Incidence d'une alimentation à base de tourteaux gras de colza sur la qualité des graisses de dépôt chez les agneaux.
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Year: 1999 Publisher: [S.l.] : [s.n.],

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Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity.

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Obesity-resistant (A/J) and obesity-prone (C57BL/6J) mice were weaned onto low-fat (LF) or high-fat (HF) diets and studied after 2, 10, and 16 wk. Despite consuming the same amount of food, A/J mice on the HF diet deposited less carcass lipid and gained less weight than C57BL/6J mice over the course of the study. Leptin mRNA was increased in white adipose tissue (WAT) in both strains on the HF diet but to significantly higher levels in A/J compared with C57BL/6J mice. Uncoupling protein 1 (UCP1) and UCP2 mRNA were induced by the HF diet in brown adipose tissue (BAT) and WAT of A/J mice, respectively, but not in C57BL/6J mice. UCP1 mRNA was also significantly higher in retroperitoneal WAT of A/J compared with C57BL/6J mice. The ability of A/J mice to resist diet-induced obesity is associated with a strain-specific increase in leptin, UCP1, and UCP2 expression in adipose tissue. The findings indicate that the HF diet does not compromise leptin-dependent regulation of adipocyte gene expression in A/J mice and suggest that maintenance of leptin responsiveness confers resistance to diet-induced obesity.


Article
Environmental enrichment and aggressive behaviour: Influence on body weight and body fat in male inbred HLG mice.
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Year: 1995

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The influence of environmentally stimulated aggressive behaviour on body weight development and body composition was studied in 90 male HLG/Zte inbred mice between day 61 and 125 of life. Male mice were kept in groups of three in Macrolon cages type III (800 cm(2)) as controls (C-groups) or in two different enriched cages (6500 cm(2)) structured either by a closed passage-way of 7.8 m (P-groups) or by 13 parallel-arranged open corridors (O-group) between fodder rack and water bottle.The number of inflicted bites as an indicator of aggressive behaviour was about 45 times higher in the P-groups than in the C- and O-groups. In P-groups the bites were predominantly found on tails (60%), while in the other two groups 90% occurred on the back.A negative correlation was found between the number of body wounds and the body weight in I-groups. Their body weight development was already significantly delayed after two weeks of differential caging compared with controls. Similarly weighing C- and O-groups showed significant differences in the body composition, i.e. standard laboratory caged C-groups were fatter. The body fat content of I-groups amounted to only about half that of the controls, which was exclusively responsible for their lower body weight.We assume that only in the I-cages the environment induced the establishment of a strong territorial dominance maintained by a single male, because it was easily possible to occupy the only existing way between fodder rack and water bottle. By contrast, a single male in the O-groups was not able to control the numerous ways to the fodder rack. The Macrolon cages were possibly too small and unstructured to establish territorial behaviour

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