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Cellular signal transduction --- Cellular signal transduction. --- STAT Transcription Factors --- Signal Transduction --- Biochemistry. --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- STAT (Signal Transducers and Activators of Transcription) Proteins --- Transcription Factors, STAT --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- cell biology --- adipose tissue --- physiology --- pathophysiology --- metabolism --- adipogenesis --- Cell Signaling --- STAT Transcription Factors. --- Signal Transduction. --- Animal Biochemistry
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General biophysics --- Biomembranes --- Cell receptors --- Congresses --- Biological transport [Active ] --- Cellular signal transduction
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Cell interaction --- Cell Communication. --- Signal Transduction. --- Cell Biology. --- Societies, Scientific. --- Cell interaction. --- Cellular Biology --- Cytology --- Biologies, Cell --- Biologies, Cellular --- Biology, Cell --- Biology, Cellular --- Cell Biologies --- Cellular Biologies --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- American Psychological Association --- Scientific Societies --- Scientific Society --- Society, Scientific --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Interaction --- Cell-to-Cell Interaction --- Cell Communications --- Cell Interactions --- Cell to Cell Interaction --- Cell-to-Cell Interactions --- Communication, Cell --- Communications, Cell --- Interaction, Cell --- Interaction, Cell-to-Cell --- Interactions, Cell --- Interactions, Cell-to-Cell --- Cell Communication --- Signal Transduction --- Societies, Scientific --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Cellular control mechanisms --- Life Sciences --- Biology --- Cell Signaling
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Cell interaction. --- Bacteria --- Symbiosis. --- Genetic transformation. --- Cellular signal transduction. --- Cell Communication. --- Gene Expression Regulation, Bacterial. --- Physiology. --- cytology. --- growth and development --- Bacteria - Physiology. --- Bacteria - cytology. --- Bacteria - growth and development --- Bacterial proteins --- Signal transduction
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Cells --- Transport Vesicles. --- Cell mechanics --- Cellular mechanics --- Biomechanics --- Endocytic Vesicles --- Endocytic Vesicle --- Transport Vesicle --- Vesicle, Endocytic --- Vesicle, Transport --- Vesicles, Endocytic --- Vesicles, Transport --- Vesicular Transport Proteins --- Mechanical properties. --- Histology. Cytology --- immunology --- neurobiology --- stem cells --- signal transduction --- membrane trafficking
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During aging, reductions in hippocampal neurogenesis are associated with memory decline indicating a causal relationship. Indeed, insulin-like growth factor-1 (IGF-1), a major activator of the extracellular receptor kinase pathway that is central in learning and memory processes, is also a key modulator of hippocampal neurogenesis. Previously, we showed that age-related declines in spatial memory tasks can be improved by antioxidant-rich diets containing blueberries. In this study, to begin to understand the mechanisms responsible for the beneficial effects of blueberries, we assessed changes in hippocampal plasticity parameters such as hippocampal neurogenesis, extracellular receptor kinase activation, and IGF-1 and IGF-1R levels in blueberry-supplemented aged animals. Our results show that all these parameters of hippocampal neuronal plasticity are increased in supplemented animals and aspects such as proliferation, extracellular receptor kinase activation and IGF-1 and IGF-1R levels correlate with improvements in spatial memory. Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity
Activation. --- Adult dentate gyrus. --- Aged rats. --- Aging. --- Alzheimers-disease. --- Animal. --- Animals. --- Antioxidants. --- Behavior. --- Cognition. --- Diet. --- Dietary supplementation. --- Environmental enrichment. --- Erk. --- Growth-factor-i. --- Growth. --- Hippocampal neurogenesis. --- Hippocampal. --- Human. --- Igf-1. --- Learning and memory. --- Learning. --- Level. --- Mechanisms. --- Medial prefrontal cortex. --- Memory. --- Modulation. --- Neurogenesis. --- Neuronal signal-transduction. --- Neuronal. --- Parameters. --- Plasticity. --- Rat. --- Rats. --- Receptor. --- Reduction. --- Spatial memory. --- Spatial. --- Task. --- Tasks. --- Time. --- Vitamin-e. --- Water maze.
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