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L’insulinome pancréatique canin est une tumeur neuroendocrine rencontrée dans plusieurs espèces dont l’Homme et le chien. Cette tumeur est caractérisée par une sécrétion excessive d’insuline entraînant des hypoglycémies récurrentes et parfois sévères pouvant engendrer des signes cliniques principalement neurologiques. L’insulinome canin est majoritairement malin et la présence de métastases, principalement lymphatiques et hépatiques, au moment du diagnostic, est fréquente. Le diagnostic est souvent permis par la conjonction d’une présentation clinique compatible, de la mise en évidence d’une hypoglycémie associée à une insulinémie inadéquate et par la présence d’une masse pancréatique visible à l’imagerie médicale ou lors d’une cœliotomie exploratrice. Le diagnostic définitif repose cependant sur l’analyse histopathologique de la masse suspecte. L’imagerie médicale est un outil important dans la prise en charge de l’insulinome tant pour son intérêt diagnostique que pour la planification de l’intervention chirurgicale et pourrait avoir un intérêt pronostic. La tomodensitométrie contrastée semble être l’examen d’imagerie de choix à l’heure actuelle en médecine vétérinaire. L’insulinome pancréatique canin s’y présente régulièrement comme une masse déformant les contours du pancréas et ayant une atténuation différente de celle du parenchyme pancréatique sain dans au moins une des phases post-contraste. L’hyperatténuation en phase artérielle n’est pas toujours constatée. L’intérêt pronostique de la tomodensitométrie reste peu étudié en médecine vétérinaire. Pourtant, l’usage de caractéristiques radiologiques et radiomiques semble pouvoir fournir, en préopératoire, des informations pronostiques supplémentaires sur les tumeurs neuroendocrines du pancréas chez l’Homme.

Insulinome canin --- Tomodensitométrie --- Imagerie médicale --- Pronostic --- Facteurs pronostiques --- Radiomique --- Insulinome --- Caractéristiques radiologiques --- Diagnostic --- Pathophysiologie --- Métastases --- Tumeur des cellules bêta --- Tumeur neuroendocrine du pancréas --- Hypoglycémie hyperinsulinémique --- Hypoglycémie --- Hyperinsulinisme --- Chien --- CT scan --- Bilan d'extension --- Sciences du vivant > Médecine vétérinaire & santé animale

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