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Hypothermia, Induced --- Longevity --- Rejuvenation --- Resuscitation
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Skin Diseases --- Skin Manifestations --- Rejuvenation --- Tissue Expansion
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Aging --- Longevity --- Rejuvenation --- Aging --- Longevity --- drug effects --- drug effects
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Rejuvenation --- Rejuvenation. --- Aging. --- Longevity. --- Length of Life --- Aging, Biological --- Biological Aging --- Senescence --- Aging --- physiology. --- Endocrinology --- Organotherapy --- Youthfulness --- Life Expectancy --- Mutation Accumulation --- Life Span --- Lifespan --- Life Spans --- Lifespans
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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia --- ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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The field of periorbital surgery has expanded exponentially in recent decades. With its rise in popularity, however, comes a rise in complications. Finally there is a comprehensive guide to repairing the problems encountered in periorbital surgery, compiled by masters in the art of periorbital surgery! This unique resource for plastic, facial plastic and oculoplastic surgeons offers several key features: Stepwise guidance for correcting a range of complications in periorbital surgery, including infection and bleeding, blindness and motility disorders, specific upper and lower eyelid problems including lid retraction, chemosis, and adverse results from fillers and resurfacing; Several chapters, presenting different approaches, devoted to the challenging problem of lid retraction and its multifactorial etiology; A case-report format that provides detailed discussions of all possible complications; Expert techniques from renowned surgeons providing multiple perspectives on the same problems; Multiple video clips showing details of eyelid evaluation and corrective techniques. -- Publisher
Blepharoplasty --- Reconstructive Surgical Procedures --- Eyelids --- Rejuvenation --- Dermal Fillers --- adverse effects --- surgery
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