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Book
DNA methyltransferases - role and function
Authors: ---
ISBN: 3031114531 303111454X Year: 2022 Publisher: Cham, Switzerland : Springer,

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Keywords

DNA. --- Methyltransferases. --- Metilació --- ADN

Protein methyltransferases.
Authors: ---
ISBN: 0121227251 9780121227258 Year: 2006 Publisher: Amsterdam Elsevier

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S-adenosylmethionine-dependent methyltransferases : structures and functions
Authors: ---
ISBN: 9810238703 Year: 1999 Publisher: Singapore ; River Edge, N.J. : World Scientific,


Multi
DNA methyltransferases - role and function
Authors: ---
ISBN: 9783031114540 9783031114533 9783031114557 9783031114564 Year: 2022 Publisher: Cham, Switzerland : Springer,

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This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. As the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.


Dissertation
The genes for two procaryotic DNA-modification methylases
Authors: ---
Year: 1989 Publisher: S.l. s.n.

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Book
Biochemistry of S-adenosylmethionine and related compounds : proceedings of a conference held at the Lake of the Ozarks (Missouri) on October 26-29, 1981
Authors: --- ---
ISBN: 1349063452 1349063436 0333330595 9780333330593 Year: 1982 Publisher: London ; Basingstoke : Macmillan,

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Book
Epigenetic modifications and viral infections
Authors: --- --- --- ---
ISBN: 9782889195879 Year: 2015 Publisher: Frontiers Media SA

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Epigenetics is defined as the study of modifications of the genome, heritable during cell division that does not involve changes in DNA sequences. Up to date, epigenetic modifications involve at least three general mechanisms regulating gene expression: histone modifications, DNA methylation, and non-coding RNAs (ncRNAs).For the past two decades, an explosion in our interest and understanding of epigenetic mechanisms has been seen. This mainly based on the influence that epigenetic alterations have on an amazing number of biological processes, such as gene expression, imprinting, programmed DNA rearrangements, germ line silencing, developmentally cued stem cell division, and overall chromosomal stability and identity.It has become also evident that the constant exposure of living organisms to environment factors affects their genomes through epigenetic mechanisms. Viruses infecting animal cells are thought to play central roles in shaping the epigenetic scenario of infected cells. In this context it has become obvious that knowing the impact that viral infections have on the epigenetic control of their host cells will certainly lead to a better understanding of the interplay viruses have with animal cells.In fact, DNA viruses use host transcription factors as well as epigenetic regulators in such a way that they affect epigenetic control of gene expression that extends to host gene expression. At the same time, animal cells employ mechanisms controlling transcription factors and epigenetic processes, in order to eliminate viral infections. In summary, epigenetic mechanisms are involved in most virus-cell interactions.We now know that some viruses exhibit epigenetic immune evasion mechanisms to survive and propagate in their host; however, there is still much ambiguity over these epigenetic mechanisms of viral immune evasion, and most of the discovered mechanisms are still incomplete. Other animal viruses associated to cancer often deregulate cellular epigenetic mechanisms, silencing cellular tumor-suppressor genes and/or activating either viral or host cell oncogenes. In addition, in several cancers the down-regulation of tumor suppressor protein-coding genes and ncRNAs with growth inhibitory functions, such as miRNAs, have been closely linked to the presence of cell CpG island promoter hypermethylation.The goal of the aforementioned Research Topic is to bring together the key experimental and theoretical research, linking state-of-the-art knowledge about the epigenetic mechanisms involved in animal virus-cell interactions.


Book
DNA and RNA modification enzymes : structure, mechanism, function, and evolution
Author:
ISBN: 9781587063299 Year: 2009 Publisher: Austin, Tex. : Landes Bioscience,


Book
The DNA, RNA, and Histone Methylomes
Authors: ---
ISBN: 3030147924 3030147916 Year: 2019 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.


Book
Marine Glycobiology, Glycomics and Lectins
Author:
ISBN: 3039218212 3039218204 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue “Marine Glycobiology, Glycomics and Lectins” of the journal Marine Drugs published scientific articles and reviews, on the background of “glycobiology”—that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences.This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.

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